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redenlab.bsky.social
Redenlab Inc.
@redenlab.bsky.social
28 followers 16 following 19 posts
A neuroscience-driven techbio.
We use speech and language biomarkers to make clinical trials smarter.
Shaping the future of speech in health.

🌐 https://redenlab.com/
🔗 https://linkedin.com/company/redenlab/
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redenlab.bsky.social
Rodent studies are essential, yet many assays don’t reflect human disease.

Motor & behavioural changes help, but mice also communicate ultrasonically - signals we can’t hear.

Adam will share how these patterns can better link preclinical models to human speech at SGV.

🧪 sgv.org/en/uuid/i/78...
November 26, 2025 at 7:03 AM
redenlab.bsky.social
Prof Angela Morgan led team calling to better differentiate speech vs language in genetics.

Clearer terms = better diagnosis & care.

With input from Prof Adam Vogel, our CSO, advancing communication science.

In @ejhg-journal.bsky.social

🧪🧠📈 www.nature.com/articles/s41...

#bskySPEECHIES
Publication highlights of the paper "Speech and language classification in the human phenotype ontology (HPO)". The right hand side features a photo of children undergoing speech therapy. Key findings: Speech & language difficulties often co-occur, but are distinct abilities. - Speech: perception & motor production of sounds - Language: understanding & producing messages (spoken/written) Current classification systems (e.g. HPO) has overlapping and inconsistent speech & language categories. Key findings: Researchers proposed a simplified and revised classification framework that distinctly separates speech & language domains and their subtypes. This framework will improve: - Precision in diagnosis & phenotyping - Targeted therapies for neurogenetic communcation disorders - Data-driven discovery from medical records worldwide To read full paper, check out link in caption. Paper is published in European Journal of Human Genetics. Author affiliations include Berlin Institute of Health, Murdoch Children's Research Institute, University of Melbourne, The Jackson Laboratory and University of Sheffield.
November 26, 2025 at 6:23 AM
redenlab.bsky.social
Struggling to follow conversations in noisy places could be a neurological condition.

New study w/ Monash, @unimelb.bsky.social, @unituebingen.bsky.social shows speech-in-noise tests may detect early cognitive changes before symptoms appear in Huntington’s disease.

🧪🧠📈 redenlab.com/examination-...
Cover page with title: Publication Highlights "Examination of speech processing in noise reveals cognitive deficits in early Huntington's disease (HD)" Key findings include: Speech-in-noise processing reveals cognitive changes in Huntington's disease, even before symptoms appear. Manifest HD: most impaired, particularly with multi-talker babble that strains executive function and working memory. Premanifest HD: subtle but measurable deficits, especially when recalling single words without context. Multi-talker noise hits hardest, reflecting working memory and attention challenges. Speech-in-noise task predicted disease status with high sensitivity and specificity - a promising remote, non-invasive screening tool. Everyday impact: Reducing background voices and using spatial cues can help people with HD communicate more easily To read the full paper, check out link in caption. Published in Cortex (with journal cover image attached). Partners include Monash University, University of Melbourne, University of Tübingen.
October 8, 2025 at 12:05 AM
redenlab.bsky.social
‪New trial shows triheptanoin may treat rare neurodegenerative disease A-T & flags biomarkers to track.

Thanks to UQ, @griffith.edu.au & more. Now in @ebiomedicine.bsky.social

🧪 redenlab.com/phase-2a-b-randomised-placebo-controlled-dose-escalation-trial-of-triheptanoin-for-ataxia-telangiectasia/
Publication highlights: Phase 2a/b randomised placebo-controlled dose-escalation trial of triheptanoin for ataxia-telangiectasia: treating mitochondrial dysfunction with anaplerosis. Key findings include: 1. Improved mitochondrial function was observed in patients with A-T treated with triheptanoin 2. Statistically significant and clinically meaningful improvements reported during the trial 3. Neurofilament light chain and interferon gene signature identified as promising biomarkers for monitoring disease progression and treatment response 4. Findings build on in vitro evidence showing that mitochondrial dysfunction in A-T cells is reversible and preventable with triheptanoin 5. Supports the potential of triheptanoin as a disease-modifying therapy for A-T To read the full paper, check out link in caption. Published in eBioMedicine. Partners include: Queensland Children's Hospital, Wesley Medical Research, University of Queensland, Griffith University, Australian Institute for Bioengineering and Nanotechnology, University of Melbourne, CSIRO Australian e-Health Research Centre, University of New South Wales, John Hunter Children's Hospital, Royal Brisbane and Women's Hospital, Garvan Institute of Medical Research, QIMR-Berghofer Research Institute. By Redenlab.
July 25, 2025 at 5:37 AM
redenlab.bsky.social
Just 10s saying “pa ta ka” can reveal early #Alzheimer’s risk.

Our new study at @geroscience.bsky.social shows speech changes predict memory, thinking skills pre-diagnosis.

Thanks to partners @wickingdementia.bsky.social, @utas.edu.au, UniMelb, Royal Hobart Hosp.

🔗: redenlab.com/rapid-repeti...
New publication by Redenlab: rapid repetitive syllable sounds associate with episodic memory, executive function, and working memory in cognitively healthy and subjectively impaired older adults. Key findings include: 10-second “pa,” “ta,” “ka” speech test predicts cognitive function in older adults. “Pa” test best linked to memory, executive function, and working memory. Speech features add predictive power beyond age, education and mood. Stronger executive function links in healthy adults; episodic memory links in those with cognitive concerns. Speech-to-pause ratio and syllable timing were key markers. The study supports remote, non-invasive early screening for Alzheimer’s risk. To read full paper, check out link in post. The study is published in GeroScience journal. Partners include: University of Melbourne, University of Tasmania, Royal Hobart Hopsital.
July 21, 2025 at 7:37 AM