Raffaele Ieva
@raffaeleieva.bsky.social
Group leader at the CNRS in Toulouse (France), working on membrane biogenesis in bacteria and mitochondria, previously at University of Bologna, Siena, NIH-Bethesda and University of Freiburg
Our study does not address the PL/LPS biosynthesis/transport coordination. However, talking about coordination, we speculate that the lipid tails of LptM help prevent that PLs of the OM inner leaflet access the lateral gate of LptD when this opens to release LPS.
November 24, 2025 at 4:52 PM
Our study does not address the PL/LPS biosynthesis/transport coordination. However, talking about coordination, we speculate that the lipid tails of LptM help prevent that PLs of the OM inner leaflet access the lateral gate of LptD when this opens to release LPS.
A special thank you also to the METI platform @cbitoulouse.bsky.social
November 24, 2025 at 4:23 PM
A special thank you also to the METI platform @cbitoulouse.bsky.social
Indeed, fantastic collaboration!
November 24, 2025 at 4:15 PM
Indeed, fantastic collaboration!
The small lipoprotein LptM intercalates the LptD lateral gate promoting gate dynamics and access by LPS. LptY (YedD) stabilizes the beta-taco domain and contributes together with LptM to optimal functioning of the Lpt transenvelope bridge.
April 11, 2025 at 6:24 AM
The small lipoprotein LptM intercalates the LptD lateral gate promoting gate dynamics and access by LPS. LptY (YedD) stabilizes the beta-taco domain and contributes together with LptM to optimal functioning of the Lpt transenvelope bridge.
The LptD beta-strand 1, defining the mobile side of the lateral gate, binds LPS and performs a stroke movement toward the external leaflet during the contracted-to-extended state transition.
April 11, 2025 at 6:24 AM
The LptD beta-strand 1, defining the mobile side of the lateral gate, binds LPS and performs a stroke movement toward the external leaflet during the contracted-to-extended state transition.
In this paper we show that LptD functions via a conformational switch of the beta-taco/beta-barrel interface, which alternates between contracted and extended states.
April 11, 2025 at 6:24 AM
In this paper we show that LptD functions via a conformational switch of the beta-taco/beta-barrel interface, which alternates between contracted and extended states.
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December 18, 2024 at 8:57 PM
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