George Zhong
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propofoldreams.bsky.social
George Zhong
@propofoldreams.bsky.social
love . death . anaesthesia

propofoldreams.org

#AnSky #TIVASky
Do not agree with routine large bore iv insertion, esp awake without local

Hope registrar learnt smth to better care for his future pts

Power imbalance and would like to hear his side of story (how he truly felt inside, in confidence, to decide if it's truly "consent" and "good friends")
August 20, 2025 at 8:44 PM
It's the same as asking a 3-Michelin star Japanese chef and a 3-Michelin star French chef: what's better, sushi or beef bourguignon?

I'm sure the Japanese chef would never go to a 3 star French restaurant and force them to make sushi ... 😅😅

#TIVASky #AnSky #ASM25CNS
May 4, 2025 at 2:05 AM
Both are very valid anaesthetic techniques, it's more about the operator than the tool.

For my pt, I prefer to use TIVA. 😁

For myself and my family, I prefer the anaesthetist use what they are best at using and then focus on other more important anaesthesia decisions.
May 4, 2025 at 1:54 AM
TIVA w NMBA = always pEEG

TIVA w/o NMBA - case by case depending on risk/benefit:

If at risk of either awareness or excessive anaesthesia depth = use pEEG

If risk is low and outweigh cost then no pEEG
May 3, 2025 at 12:10 PM
I suspect when plotting probability of inciting debate vs provocativeness of a comment, it's a (upside down) parabolic relationship

The only difference is in the coefficients 😅😅
April 19, 2025 at 11:36 AM
Thank you for all your interest in our work. Due to popular demand, here's the link to our article behind paywall, free for 50 days

authors.elsevier.com/a/1kWpX1dCDy...

Thank you @bjajournals.bsky.social

#TIVASky #AnSky #TCI
authors.elsevier.com
February 2, 2025 at 10:22 PM
Of course, depth of anaesthesia is a 3-way balance between
(1) PK (how much propofol)
(2) PD (pt sensitivity)
(3) how much stimulus

It seems from our study that when stimulus is standardised (i.e. minimised), it may be possible to reliably predict wake up time 🤔🤔
February 2, 2025 at 4:02 AM
To try our wake up prediction algorithm today, just search for Propofol Dreams in the app store on your phone. Free for the world forever!

propofoldreams.org

Reference doi:
10.1016/j.bja.2025.01.007
February 1, 2025 at 6:00 AM
As a pilot study, we validated our novel prediction algorithm in 2 small cohorts of patients: painful and non-painful surgeries (defined as whether additional analgesics were required in PACU). The predictive value of the algorithm was excellent, esp in the No Pain group. 7/7
February 1, 2025 at 6:00 AM
EXPERIMENT: we tested our hypothesis by examining a simplified cohort of patients where external stimuli (pain, verbal, tactile) at the time of emergence were minimised.
We built a hybrid regression model that predicts the awakening Cp for from maintenance Cp and SE. 6/7
February 1, 2025 at 6:00 AM
HYPOTHESIS: if we solve for the sigmoid Emax model parameters using maintenance phase data (propofol concentration, state entropy) for a given patient, we may then be able to use these to predict their individualised awakening propofol concentration 5/7
February 1, 2025 at 6:00 AM
ASSUMPTION: the Hill coefficient and other model parameters quantifying the pharmacodynamic effect of propofol are unchanged between the maintenance phase shortly before emergence and at the time of emergence 4/7
February 1, 2025 at 6:00 AM
LEMMA: the sigmoid Emax model relates propofol concentration to its pharmacodynamic effect. 3/7
February 1, 2025 at 6:00 AM
We came up with a novel algorithm for predicting individualised wake up Cp during propofol TCI based on:
(1) maintenance Cp
(2) corresponding state entropy
Here's how we did it. 2/7
February 1, 2025 at 6:00 AM
You can also mimic Eleveld infusion regime almost exactly by using Marsh on your existing pump together with an adjusted input weight. 😜😜

propofoldreams.org/elemarsh-mode/
EleMarsh Mode – Propofol Dreams
propofoldreams.org
January 27, 2025 at 5:54 AM
Have used all 4. BD Nexus and Agilia (Fresenius) are both good daily drivers
Don't mind the Braun

Not a fan of the Arcomed because it's clunky to exchange syringes (hardware issue) and over the top safety confirmations (litigation avoidant > clinician centred design, easy software fix)
January 27, 2025 at 5:51 AM
Or "inadequate trace, check place"

But I agree with you, it's a risk-benefit balance of a catchy rhyme that efficiently raises awareness vs inducing cognitive bias
December 14, 2024 at 11:44 AM
I feel the problem with "no trace, wrong place" is that there are two negatives (no and wrong) which are easy to mentally flip, which then becomes the unintended message of "yes trace, right place"

What about using verbs which cannot be easily flipped like
"abnormal trace, check place"
December 14, 2024 at 11:41 AM