Louise Marston
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proflouisemarston.bsky.social
Louise Marston
@proflouisemarston.bsky.social
100 followers 67 following 82 posts
Professor of Clinical Trials Statistics at Priment Clinical Trials Unit, UCL. England rugby fan, Trailfinders Women. Often out taking photographs.
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proflouisemarston.bsky.social
Validated self-administered screening tools to identify depression among young adults (18 to 25-years-old) in East Asia and the Pacific Region low-and-middle income countries (LMICs): A systematic review by my PhD student Dennis Dantic. https//www.science... @ucl-primarycare.bsky.social
tools for symptoms of depression among young adults (18 to 25 years old) in East Asia and the Pacific. A total of 22 studies with 24,069 participants were included, covering both clinical and non-clinical populations. Nine selfadministered screening tools were identified, with Patient Health Questionnaire-9 (PHQ-9), Patient Health Questionnaire-2 PHQ-2, and Centre for Epidemiological Studies Depression (CES-D) being the most frequently studied. PHQ-9 demonstrated moderate to excellent internal consistency reliability, with Cronbach’s alpha ranging from 0.67 to 0.92, and a pooled AUC of 0.86, indicating strong screening accuracy. PHQ-2, showed an Area Under the Curve (AUC) of 0.85, high sensitivity (0.96), and moderate specificity (0.80). CES-D exhibited an AUC of 0.87, good sensitivity (0.81), and specificity (0.78), with high heterogeneity (I² = 74.70 %–86.69 %). The meta-analysis revealed substantial variability in sensitivity and specificity across settings, with differences in study methodologies, cutoff scores, and reference standards contributing to high heterogeneity. Additionally, 95.5 % of studies had a moderate risk of bias in patient selection, affecting generalizability. Despite these limitations, PHQ-9, PHQ-2, and CES-D remain valuable tools for identifying symptoms of depression among young adults. The accessibility, ease of administration, and strong psychometric properties of these tests support their continued use in resource-limited settings, though standardization of methodologies and expanded regional validation are needed to improve screening accuracy and applicability.
November 26, 2025 at 8:55 AM
proflouisemarston.bsky.social
Evidence for health promotion interventions to improve cognitive and physical functioning outcomes in older adults with MCI: A state-of-the-art review www.sciencedirect.com/science/arti... @ucl-caps.bsky.social @ucl-primarycare.bsky.social @drmegs.bsky.social @tasminrookes.bsky.social
Background Health promotion activities for people with mild cognitive impairment (MCI) may improve their overall health and prevent progression to dementia. We need to understand the best approaches to behaviour change in this population. Aim To summarise the types of health promotion interventions and current clinical effectiveness evidence for physical and cognitive functioning outcomes in people with MCI. Design State-of-the art review Method Medline was searched in April 2025, for systematic reviews synthesising randomised controlled trials testing effectiveness of health promotion interventions in older adults with MCI, published since 2015. Abstracts, titles, and full texts were single screened and, for eligible reviews, the characteristics, intervention type, primary outcome, and evidence for people with MCI, were extracted. Key messages were narratively synthesised across reviews, grouping by type of intervention and outcome measure. Results From 1776 titles and abstracts, 57 systematic reviews were eligible. Regular moderate intensity multicomponent physical exercise and memory-focussed cognitive training interventions had the strongest evidence base for improving cognitive functioning. However, combining physical exercise and cognitive training was more beneficial for cognitive domains and physical functioning, in comparison to doing them individually. The evidence for nutrition interventions was mixed. One review of psychological interventions showed improvements for wellbeing. Conclusion There is evidence that health promotion interventions can support people with MCI and dementia to improve or maintain their cognitive function, through multicomponent physical activity combined with cognitive training. More evidence is needed for nutritional recommendations, psychological interventions, and social inclusion interventions.
October 7, 2025 at 6:26 PM
proflouisemarston.bsky.social
I have just been bought this!
September 12, 2025 at 12:33 PM
proflouisemarston.bsky.social
Outcomes of specialist physiotherapy for functional motor disorder: the Physio4FMD RCT NIHR report out today www.journalslibrary.nihr.ac.uk/hta/MKAC9495 @nihr.bsky.social @ucl-primarycare.bsky.social @gnielsenphysio.bsky.social @jonstoneneuro.bsky.social
July 31, 2025 at 5:58 PM
proflouisemarston.bsky.social
Methylphenidate versus placebo for fatigue in patients with advanced cancer: the MePFAC randomised controlled trial @nihr.bsky.social report out today. @ucl-primarycare.bsky.social www.journalslibrary.nihr.ac.uk/hta/GJPS6321
Front page of the MePFAC HTA report with abstract.
July 31, 2025 at 4:47 PM
proflouisemarston.bsky.social
The association between relapse and the outcome of schizophrenia and recurrent psychotic disorders doi.org/10.1192/bjp.... @joannamoncrieff.bsky.social @soniajohnson1.bsky.social @ucl-primarycare.bsky.social @uclpsychiatry.bsky.social
Abstract from BJPsych for paper: The association between relapse and the outcome of schizophrenia and recurrent psychotic disorders.
April 14, 2025 at 6:37 PM
proflouisemarston.bsky.social
Exploring the effect of COVID-19 restrictions on the social functioning scale in a clinical trial of antipsychotic reduction: using multiple imputation to target a hypothetical estimand is out in @jclinepi.bsky.social www.sciencedirect.com/science/arti... 1/n
March 29, 2025 at 11:24 AM
proflouisemarston.bsky.social
researchinvolvement.biomedcentral.com/articles/10.... PETAL PPIE involvement in developing the intervention. @proflikahass.bsky.social @ucl-primarycare.bsky.social @uclpsychiatry.bsky.social
March 6, 2025 at 3:31 PM
proflouisemarston.bsky.social
Cost-Utility Analysis of Antipsychotic Reduction and Discontinuation in Patients With Long-Term Schizophrenia and Psychosis in English Mental Health Trusts: The RADAR Study

www.valueinhealthjournal.com/article/S109... @ucl-primarycare.bsky.social @uclpsychiatry.bsky.social
February 27, 2025 at 4:34 PM
proflouisemarston.bsky.social
Mediation of the association between education and dementia by occupational complexity, income, health behaviours and health outcomes @ucl-primarycare.bsky.social @uclpsychiatry.bsky.social
February 26, 2025 at 7:35 AM
proflouisemarston.bsky.social
Which factors predict outcome from specialist physiotherapy for functional motor disorder? Prognostic modelling of the Physio4FMD intervention @ucl-primarycare.bsky.social
Abstract for Which factors predict outcome from specialist physiotherapy for FMD? Prognostic modelling of the Physio4FMD intervention
February 13, 2025 at 5:03 PM
proflouisemarston.bsky.social
An investigation into the critical ingredients of intensive support teams for adults with intellectual disabilities who display challenging behaviour www.cambridge.org/core/journal... @proflikahass.bsky.social @ucl-primarycare.bsky.social @uclpsychiatry.bsky.social
Screenshot of the first page of An investigation into the critical ingredients of intensive support teams for adults with intellectual disabilities who display challenging behaviour.
February 11, 2025 at 1:31 PM
proflouisemarston.bsky.social
Estimating undiagnosed dementia in England using capture recapture techniques doi.org/10.1186/s128... @ucl-primarycare.bsky.social
Screenshot of the abstract from Estimating undiagnosed dementia in England using capture recapture techniques.
January 2, 2025 at 1:13 PM
proflouisemarston.bsky.social
This is what my Guides made last night. Managed to sell it all. Rocky road/ fridge cake
Slices of rocky road with gingerbread men decorations on a white plate
November 30, 2024 at 2:46 PM
proflouisemarston.bsky.social
Good morning to you too. Have a good day.
Sunrise over Kew Bridge
November 29, 2024 at 7:13 AM