Pablo Pelegrin
@ppelegrin.bsky.social
Immunology Professor @um.es. PI of Molecular Inflammation research group @imib
Honored to be selected as #HighlyCited2025 researcher by @clarivateag.bsky.social. Grateful for my present and past lab members, institutions and funding agencies who make our work possible.
@um.es
@um.es
Did you know? Our #HighlyCited2025 list names 6,868 individuals with 7,131 Highly Cited Researcher awards.
For deeper insight into the list, read our 2025 Analysis: clarivate.com/highly-cited...
For deeper insight into the list, read our 2025 Analysis: clarivate.com/highly-cited...
November 13, 2025 at 10:39 PM
Honored to be selected as #HighlyCited2025 researcher by @clarivateag.bsky.social. Grateful for my present and past lab members, institutions and funding agencies who make our work possible.
@um.es
@um.es
Honored to be selected as #HighlyCited2025 researcher by @clarivateag.bsky.social. Grateful for my present and past lab members, institutions and funding agencies who make our work possible.
@um.es
@erc.europa.eu
@horizoneu.bsky.social
@umudivulga.bsky.social
clarivate.com/highly-cited...
@um.es
@erc.europa.eu
@horizoneu.bsky.social
@umudivulga.bsky.social
clarivate.com/highly-cited...
clarivate.com
November 13, 2025 at 5:21 PM
Honored to be selected as #HighlyCited2025 researcher by @clarivateag.bsky.social. Grateful for my present and past lab members, institutions and funding agencies who make our work possible.
@um.es
@erc.europa.eu
@horizoneu.bsky.social
@umudivulga.bsky.social
clarivate.com/highly-cited...
@um.es
@erc.europa.eu
@horizoneu.bsky.social
@umudivulga.bsky.social
clarivate.com/highly-cited...
Reposted by Pablo Pelegrin
Today we announce the Highly Cited Researchers 2025 list—celebrating 6,868 individuals from over 1,300 institutions across 60 countries. #HighlyCited2025
Read the full press release: clarivate.com/news/clariva...
Read the full press release: clarivate.com/news/clariva...
November 12, 2025 at 8:17 AM
Today we announce the Highly Cited Researchers 2025 list—celebrating 6,868 individuals from over 1,300 institutions across 60 countries. #HighlyCited2025
Read the full press release: clarivate.com/news/clariva...
Read the full press release: clarivate.com/news/clariva...
Reposted by Pablo Pelegrin
#ToPrimeOrNotToPrime, this is the question! Excited for our new review @cp-trendsimmuno.bsky.social with @oceanedufies.bsky.social in which we discuss what is “priming” for the #NLRP3 #inflammasome & how we can harness this knowledge to better control human diseases! #InflammasomePower! #Free 👇👇👇
ScienceDirect.com | Science, health and medical journals, full text articles and books.
authors.elsevier.com
November 10, 2025 at 5:26 PM
#ToPrimeOrNotToPrime, this is the question! Excited for our new review @cp-trendsimmuno.bsky.social with @oceanedufies.bsky.social in which we discuss what is “priming” for the #NLRP3 #inflammasome & how we can harness this knowledge to better control human diseases! #InflammasomePower! #Free 👇👇👇
Reposted by Pablo Pelegrin
#Nature #NewsFeature 7 basic science discoveries that changed the world. Ozempic, MRI machines and flat screen televisions all emerged out of fundamental research decades earlier. www.nature.com/articles/d41... cc @lluismontoliu.bsky.social
October 31, 2025 at 4:44 PM
#Nature #NewsFeature 7 basic science discoveries that changed the world. Ozempic, MRI machines and flat screen televisions all emerged out of fundamental research decades earlier. www.nature.com/articles/d41... cc @lluismontoliu.bsky.social
Reposted by Pablo Pelegrin
#InflammasomePower! 💥New paper alert💥 How is NLPR3 primed & activated in chronic non-communicable inflammatory diseases? With @oceanedufies.bsky.social &co we show that chronic exposure to oxPAPC drives NRF2 activation that primes & activates NLRP3 sustaining #atherosclerosis in mice & humans! 👇👇👇
Chronic sensing of host-derived lipids is an all-in-one signal that primes and activates NLRP3.
Activation of the NLRP3 inflammasome leads to the production of bioactive interleukin (IL)-1β fostering atherosclerosis. The current dogma is that NLRP3 must be first primed by microbial stimuli, know...
www.biorxiv.org
October 31, 2025 at 3:49 PM
#InflammasomePower! 💥New paper alert💥 How is NLPR3 primed & activated in chronic non-communicable inflammatory diseases? With @oceanedufies.bsky.social &co we show that chronic exposure to oxPAPC drives NRF2 activation that primes & activates NLRP3 sustaining #atherosclerosis in mice & humans! 👇👇👇
Reposted by Pablo Pelegrin
#SpookyInflammasome 🎃
With @lozanzi.bsky.social &co, we show that sustained NRF2 activation by endogenous oxidized phospholipids primes and activates the NLRP3 inflammasome 🔥 to drive atherosclerosis.
... more to come on the priming !
With @lozanzi.bsky.social &co, we show that sustained NRF2 activation by endogenous oxidized phospholipids primes and activates the NLRP3 inflammasome 🔥 to drive atherosclerosis.
... more to come on the priming !
#InflammasomePower! 💥New paper alert💥 How is NLPR3 primed & activated in chronic non-communicable inflammatory diseases? With @oceanedufies.bsky.social &co we show that chronic exposure to oxPAPC drives NRF2 activation that primes & activates NLRP3 sustaining #atherosclerosis in mice & humans! 👇👇👇
Chronic sensing of host-derived lipids is an all-in-one signal that primes and activates NLRP3.
Activation of the NLRP3 inflammasome leads to the production of bioactive interleukin (IL)-1β fostering atherosclerosis. The current dogma is that NLRP3 must be first primed by microbial stimuli, know...
www.biorxiv.org
October 31, 2025 at 5:37 PM
#SpookyInflammasome 🎃
With @lozanzi.bsky.social &co, we show that sustained NRF2 activation by endogenous oxidized phospholipids primes and activates the NLRP3 inflammasome 🔥 to drive atherosclerosis.
... more to come on the priming !
With @lozanzi.bsky.social &co, we show that sustained NRF2 activation by endogenous oxidized phospholipids primes and activates the NLRP3 inflammasome 🔥 to drive atherosclerosis.
... more to come on the priming !
Reposted by Pablo Pelegrin
Thank you to our editor, Kirsty Minton, and the staff at NRI for the opportunity to share our thoughts on this emerging topic.
NEW Perspective by @alazozcan.bsky.social, Tommaso Vicanolo, Veronique Angeli, Yuval Rinkevich & @drusqui.bsky.social presents a model of immune cells as architects of tissue barriers, by depositing matrix components or by interactions with structural cells and the ECM
#structuralimmunity #immunosky
#structuralimmunity #immunosky
Structural immunity: immune cells as architects of tissue barriers - Nature Reviews Immunology
This Perspective presents a framework of ‘structural immunity’ that positions immune cells as architects of tissue structure. Beyond their roles in antimicrobial defence, we posit that immune cells co...
www.nature.com
October 28, 2025 at 4:41 PM
Thank you to our editor, Kirsty Minton, and the staff at NRI for the opportunity to share our thoughts on this emerging topic.
Reposted by Pablo Pelegrin
Fantastic new story @jkagan1.bsky.social & friends showing that human dendritic cells can become hyperactive activating the inflammasome without dying, & that this approach can be used in mice and NHPs to potentiate anti-influenza vaccine responses! 👇👇👇
An NLRP3 stimulatory universal influenza vaccine.
We report an NLRP3 stimulus that generates hyperactive dendritic cells (hDCs).
journals.asm.org/doi/10.1128/...
We report an NLRP3 stimulus that generates hyperactive dendritic cells (hDCs).
journals.asm.org/doi/10.1128/...
An NLRP3-stimulatory adjuvant improves the immunogenicity of influenza virus vaccines in mice and non-human primates | mBio
The generation of vaccines that stimulate T cell activities is an unmet need for the
scientific community, as T cells are the primary mediators of immune memory. In this
study, we report a new vaccine...
journals.asm.org
September 8, 2025 at 8:30 PM
Fantastic new story @jkagan1.bsky.social & friends showing that human dendritic cells can become hyperactive activating the inflammasome without dying, & that this approach can be used in mice and NHPs to potentiate anti-influenza vaccine responses! 👇👇👇
Looking for passionate candidate to apply to PhD fellowship to University of Murcia call:
www.um.es/documents/d/...
Interested students contact me!
www.um.es/documents/d/...
Interested students contact me!
www.um.es
September 7, 2025 at 4:57 PM
Looking for passionate candidate to apply to PhD fellowship to University of Murcia call:
www.um.es/documents/d/...
Interested students contact me!
www.um.es/documents/d/...
Interested students contact me!
Reposted by Pablo Pelegrin
Cheng, Qiu et al @jhu.edu provide new insights into the molecular mechanism of #phagosome maturation and the dynamics of host defense response following phagosome-mediated bacterial degradation in peritoneal #macrophages. rupress.org/jem/article/...
#InnateImmunity #inflammation #InfectiousDisease
#InnateImmunity #inflammation #InfectiousDisease
September 5, 2025 at 7:15 PM
Cheng, Qiu et al @jhu.edu provide new insights into the molecular mechanism of #phagosome maturation and the dynamics of host defense response following phagosome-mediated bacterial degradation in peritoneal #macrophages. rupress.org/jem/article/...
#InnateImmunity #inflammation #InfectiousDisease
#InnateImmunity #inflammation #InfectiousDisease
Reposted by Pablo Pelegrin
So excited that this study is now online! It's been a pleasure to work with BioAge Labs and our collaborators on this story. We characterise a new class of #NLRP3 inhibitors with translational potential for so many inflammatory diseases.
#NLRP3 is a target for antiinflammatory therapies & can be inhibited by the tool compound MCC950. Wilhelmsen, @colllab.bsky.social et al characterize new small-molecule inhibitors, BAL-0028 & BAL-0598, that have a distinct mechanism of action & binding site. rupress.org/jem/article/...
#Inflammasome
#Inflammasome
September 2, 2025 at 4:22 PM
So excited that this study is now online! It's been a pleasure to work with BioAge Labs and our collaborators on this story. We characterise a new class of #NLRP3 inhibitors with translational potential for so many inflammatory diseases.
Reposted by Pablo Pelegrin
#NLRP3 is a target for antiinflammatory therapies & can be inhibited by the tool compound MCC950. Wilhelmsen, @colllab.bsky.social et al characterize new small-molecule inhibitors, BAL-0028 & BAL-0598, that have a distinct mechanism of action & binding site. rupress.org/jem/article/...
#Inflammasome
#Inflammasome
September 2, 2025 at 4:15 PM
#NLRP3 is a target for antiinflammatory therapies & can be inhibited by the tool compound MCC950. Wilhelmsen, @colllab.bsky.social et al characterize new small-molecule inhibitors, BAL-0028 & BAL-0598, that have a distinct mechanism of action & binding site. rupress.org/jem/article/...
#Inflammasome
#Inflammasome
Reposted by Pablo Pelegrin
Review @natimmunol.nature.com
The expanding role of the NLRP3 inflammasome from periodic fevers to therapeutic targets
www.nature.com/articles/s41...
The expanding role of the NLRP3 inflammasome from periodic fevers to therapeutic targets
www.nature.com/articles/s41...
August 18, 2025 at 5:30 PM
Review @natimmunol.nature.com
The expanding role of the NLRP3 inflammasome from periodic fevers to therapeutic targets
www.nature.com/articles/s41...
The expanding role of the NLRP3 inflammasome from periodic fevers to therapeutic targets
www.nature.com/articles/s41...
Reposted by Pablo Pelegrin
#InterferonPower! Thrilled for our latest work @cp-cell.bsky.social! With @danielboehmer.bsky.social, we dug into tons of papers & created what we hope will be a go-to resource for immunologists & non-immunologist about type I, II, III (& IV😉) #interferons! Free👉 authors.elsevier.com/a/1leKGL7PXu...
August 21, 2025 at 3:20 PM
#InterferonPower! Thrilled for our latest work @cp-cell.bsky.social! With @danielboehmer.bsky.social, we dug into tons of papers & created what we hope will be a go-to resource for immunologists & non-immunologist about type I, II, III (& IV😉) #interferons! Free👉 authors.elsevier.com/a/1leKGL7PXu...
Reposted by Pablo Pelegrin
🚨It’s out @embojournal.org 🚨
Cardiolipin inhibits Caspase-4/11!
Huge thanks to my brilliant supervisors Kate & Pablo, to @s-burgener.bsky.social & Mercedes and all the @inflammasomelab.bsky.social, it was a joy working and laughing with you, and to @brozlab.bsky.social & Si Ming lab.
Cardiolipin inhibits Caspase-4/11!
Huge thanks to my brilliant supervisors Kate & Pablo, to @s-burgener.bsky.social & Mercedes and all the @inflammasomelab.bsky.social, it was a joy working and laughing with you, and to @brozlab.bsky.social & Si Ming lab.
July 23, 2025 at 11:23 AM
🚨It’s out @embojournal.org 🚨
Cardiolipin inhibits Caspase-4/11!
Huge thanks to my brilliant supervisors Kate & Pablo, to @s-burgener.bsky.social & Mercedes and all the @inflammasomelab.bsky.social, it was a joy working and laughing with you, and to @brozlab.bsky.social & Si Ming lab.
Cardiolipin inhibits Caspase-4/11!
Huge thanks to my brilliant supervisors Kate & Pablo, to @s-burgener.bsky.social & Mercedes and all the @inflammasomelab.bsky.social, it was a joy working and laughing with you, and to @brozlab.bsky.social & Si Ming lab.
Reposted by Pablo Pelegrin
Have you ever wondered whether pyroptotic corpses have functions beyond the grave? We made the surprising discovery that pyroptotic corpses are flagged by #filopodia to alert #DendriticCells they need autopsy. A short Bluetorial (1/13)👇with movies!
Link: rdcu.be/d2mjm
Link: rdcu.be/d2mjm
Pyroptotic cell corpses are crowned with F-actin-rich filopodia that engage CLEC9A signaling in incoming dendritic cells
Nature Immunology - Pyroptotic cell death results in inflammation. Here the authors find that F-actin-rich structures formed during macrophage pyroptosis persist after cell death to activate...
rdcu.be
December 9, 2024 at 1:39 AM
Have you ever wondered whether pyroptotic corpses have functions beyond the grave? We made the surprising discovery that pyroptotic corpses are flagged by #filopodia to alert #DendriticCells they need autopsy. A short Bluetorial (1/13)👇with movies!
Link: rdcu.be/d2mjm
Link: rdcu.be/d2mjm