Paul Sauer
@paulsauer.bsky.social
Structural Biologist and outdoor enthusiast
Reposted by Paul Sauer
🚨 BREAKING: OMB has just issued a memo *rescinding* the previous memo freezing all federal financial assistance programs.
Full text, per government source:
Full text, per government source:
January 29, 2025 at 5:48 PM
🚨 BREAKING: OMB has just issued a memo *rescinding* the previous memo freezing all federal financial assistance programs.
Full text, per government source:
Full text, per government source:
Our first paper here at #interdictbio!
Excited to share the 1st preprint from our incredible team at Interdict Bio as we progress novel, small-molecule sequence-selective inhibitors of translation toward the clinic to address difficult to treat cancers! #ribosome #interdictor
Check out the preprint here: www.biorxiv.org/content/10.1...
Check out the preprint here: www.biorxiv.org/content/10.1...
Context-dependent translation inhibition as a novel oncology therapeutic modality
Inhibitors of protein synthesis, including anisomycin, homoharringtonine, and other natural products bind in the peptidyl-transferase center (PTC) of the eukaryotic ribosome to inhibit translation. Re...
www.biorxiv.org
January 22, 2025 at 6:43 AM
Our first paper here at #interdictbio!
Reposted by Paul Sauer
As someone who grew up in Austria I am really concerned about the apparent lack of concern. y'all should distribute the small book 'Biedermann und die Brandstifter' by Max Frisch ("The Fire Raisers: A Morality Without a Moral,"), which lays it out in detail. 🧵
January 21, 2025 at 1:24 PM
As someone who grew up in Austria I am really concerned about the apparent lack of concern. y'all should distribute the small book 'Biedermann und die Brandstifter' by Max Frisch ("The Fire Raisers: A Morality Without a Moral,"), which lays it out in detail. 🧵
Reposted by Paul Sauer
"On a molecular level, our structural studies reveal that interdictors bind in a linkerless heterobifunctional manner to both the rRNA and the nascent peptide chain ... much the way a PROTAC can be modularly designed and constructed"
January 10, 2025 at 8:00 PM
"On a molecular level, our structural studies reveal that interdictors bind in a linkerless heterobifunctional manner to both the rRNA and the nascent peptide chain ... much the way a PROTAC can be modularly designed and constructed"
Reposted by Paul Sauer
Is RNA translation the next hot area in #cancer therapeutics?
Take a look and make a decision for yourself!
#RNAsky
#ONCSky
🧬 💻
#genomics
www.biorxiv.org/content/10.1...
Take a look and make a decision for yourself!
#RNAsky
#ONCSky
🧬 💻
#genomics
www.biorxiv.org/content/10.1...
Context-dependent translation inhibition as a novel oncology therapeutic modality
Inhibitors of protein synthesis, including anisomycin, homoharringtonine, and other natural products bind in the peptidyl-transferase center (PTC) of the eukaryotic ribosome to inhibit translation. Re...
www.biorxiv.org
January 10, 2025 at 1:23 PM
Is RNA translation the next hot area in #cancer therapeutics?
Take a look and make a decision for yourself!
#RNAsky
#ONCSky
🧬 💻
#genomics
www.biorxiv.org/content/10.1...
Take a look and make a decision for yourself!
#RNAsky
#ONCSky
🧬 💻
#genomics
www.biorxiv.org/content/10.1...
Congratulations @trinitycookis.bsky.social for a great paper! Biochemical and structural disscection of PRC2 activation and inhibition by modified histones!
Work led by graduate student @trinitycookis.bsky.social and coauthors Alexandria Lydecker, @paulsauer.bsky.social, and @kasinath-lab.bsky.social is out today where we looked at the inhibition of PRC2 by histone PTMs associated with regions of active transcription.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Structural basis for the inhibition of PRC2 by active transcription histone posttranslational modifications - Nature Structural & Molecular Biology
Structures reveal that histone H3K36me3 and H3K4me3 modifications reduce Polycomb repressive complex 2 (PRC2) function through the inhibition of histone tail engagement and antagonistic binding to the...
www.nature.com
January 10, 2025 at 11:30 AM
Congratulations @trinitycookis.bsky.social for a great paper! Biochemical and structural disscection of PRC2 activation and inhibition by modified histones!