Patrickthebiosteamist
@patbiosteamist.bsky.social
Engineer & Scientist.
Breaks down Covid papers & data.
Masked fitness series.
All views expressed are my own, I speak from a US perspective.
Not a Covid researcher nor a Covid scientist.
youtube.com/@patrickthebiosteamist?si=FoWeCh6fdBWY5jEt
Breaks down Covid papers & data.
Masked fitness series.
All views expressed are my own, I speak from a US perspective.
Not a Covid researcher nor a Covid scientist.
youtube.com/@patrickthebiosteamist?si=FoWeCh6fdBWY5jEt
This is a reminder that the PAXCESS program through Pfizer for free Paxlovid for those uninsured or underinsured is ending this December 31, 2025.
If you happen to catch Covid prior to the end of December, please utilize the program before it is gone!
www.paxlovid.com/paxcess?cmp=...
If you happen to catch Covid prior to the end of December, please utilize the program before it is gone!
www.paxlovid.com/paxcess?cmp=...
PAXCESS™ | PAXLOVID™ (nirmatrelvir tablets; ritonavir tablets)
The PAXCESS™ Patient Support Program may help eligible patients lower the cost of PAXLOVID™ and access savings, with or without insurance. T&Cs apply.
www.paxlovid.com
November 29, 2025 at 4:18 AM
This is a reminder that the PAXCESS program through Pfizer for free Paxlovid for those uninsured or underinsured is ending this December 31, 2025.
If you happen to catch Covid prior to the end of December, please utilize the program before it is gone!
www.paxlovid.com/paxcess?cmp=...
If you happen to catch Covid prior to the end of December, please utilize the program before it is gone!
www.paxlovid.com/paxcess?cmp=...
Reposted by Patrickthebiosteamist
Amazing analogy.
Just gotta top her off, the ol’ immunity. Keep her running nice through the season.
Ironically, the ideal number of times to get vaccinated for healthy people would also be 3-4 times a year.
Just gotta top her off, the ol’ immunity. Keep her running nice through the season.
Ironically, the ideal number of times to get vaccinated for healthy people would also be 3-4 times a year.
“If vaccines work, why would you need a booster?” he asks as he changes his oil for the third time that year.
November 28, 2025 at 10:53 PM
Amazing analogy.
Just gotta top her off, the ol’ immunity. Keep her running nice through the season.
Ironically, the ideal number of times to get vaccinated for healthy people would also be 3-4 times a year.
Just gotta top her off, the ol’ immunity. Keep her running nice through the season.
Ironically, the ideal number of times to get vaccinated for healthy people would also be 3-4 times a year.
Reposted by Patrickthebiosteamist
The Nebraska cryptic lineage appeared again this week. It really puts BA.3.2.2 in perspective.
November 28, 2025 at 3:32 PM
The Nebraska cryptic lineage appeared again this week. It really puts BA.3.2.2 in perspective.
Reposted by Patrickthebiosteamist
Already two more BA.3.2.2 from Ireland today, both closely related to the first (and both with the ORF1a:∆141-143 deletion also found in most European BA.3.2.1).
Only real change was N:T271S in one of the two. (A29086T was inherited, but C->G muts like this are very rare.)
Only real change was N:T271S in one of the two. (A29086T was inherited, but C->G muts like this are very rare.)
November 28, 2025 at 7:58 PM
Already two more BA.3.2.2 from Ireland today, both closely related to the first (and both with the ORF1a:∆141-143 deletion also found in most European BA.3.2.1).
Only real change was N:T271S in one of the two. (A29086T was inherited, but C->G muts like this are very rare.)
Only real change was N:T271S in one of the two. (A29086T was inherited, but C->G muts like this are very rare.)
Phases of Covid Infection - Part 2
youtu.be/G5xH4rR8FFE
youtu.be/G5xH4rR8FFE
Phases of Covid Infection - Part 2
YouTube video by PatricktheBioSTEAMist
youtu.be
November 28, 2025 at 7:51 PM
Phases of Covid Infection - Part 2
youtu.be/G5xH4rR8FFE
youtu.be/G5xH4rR8FFE
Reposted by Patrickthebiosteamist
BA.3.2 detected again in New Zealand wastewater 💩
Week ended:
💠5 Oct 3.7%
💠2 Nov 1.4%
💠9 Nov 2.0%
#BA32 🎃
Variants with a national percentage of less than 1% are not shown
1/
Week ended:
💠5 Oct 3.7%
💠2 Nov 1.4%
💠9 Nov 2.0%
#BA32 🎃
Variants with a national percentage of less than 1% are not shown
1/
November 27, 2025 at 4:46 AM
BA.3.2 detected again in New Zealand wastewater 💩
Week ended:
💠5 Oct 3.7%
💠2 Nov 1.4%
💠9 Nov 2.0%
#BA32 🎃
Variants with a national percentage of less than 1% are not shown
1/
Week ended:
💠5 Oct 3.7%
💠2 Nov 1.4%
💠9 Nov 2.0%
#BA32 🎃
Variants with a national percentage of less than 1% are not shown
1/
Reposted by Patrickthebiosteamist
Histotripsy uses focused sound waves to destroy tumours safely while sparing healthy tissue.
Histotripsy: how sound waves could change the future of tumour treatment
Histotripsy uses focused sound waves to destroy tumours safely while sparing healthy tissue.
tcnv.link
November 27, 2025 at 9:15 PM
Histotripsy uses focused sound waves to destroy tumours safely while sparing healthy tissue.
Made an Aranet 4 case today. You can download it for free on cults3d, printables, or makerworld
November 27, 2025 at 7:14 PM
Made an Aranet 4 case today. You can download it for free on cults3d, printables, or makerworld
Reposted by Patrickthebiosteamist
Another US BA.3.2 wastewater detection.
This time from Bristol County, RI on Nov 11. It was about a third of the seqs.
I wonder if it was someone who flew back from Australia through SF?
@ryanhisner.bsky.social @snpoehlm.bsky.social @rajlabn.bsky.social
This time from Bristol County, RI on Nov 11. It was about a third of the seqs.
I wonder if it was someone who flew back from Australia through SF?
@ryanhisner.bsky.social @snpoehlm.bsky.social @rajlabn.bsky.social
November 26, 2025 at 11:01 PM
Another US BA.3.2 wastewater detection.
This time from Bristol County, RI on Nov 11. It was about a third of the seqs.
I wonder if it was someone who flew back from Australia through SF?
@ryanhisner.bsky.social @snpoehlm.bsky.social @rajlabn.bsky.social
This time from Bristol County, RI on Nov 11. It was about a third of the seqs.
I wonder if it was someone who flew back from Australia through SF?
@ryanhisner.bsky.social @snpoehlm.bsky.social @rajlabn.bsky.social
From Mike Honey’s data, it looks like BA.3.2 is starting to take off in a few places - notably Australia and Germany.
This variant could be our next BA.2.86 (which later became the dominant JN.1).
At this time, a very possible recombination with an XFG variant could easily kick this off.
This variant could be our next BA.2.86 (which later became the dominant JN.1).
At this time, a very possible recombination with an XFG variant could easily kick this off.
November 26, 2025 at 9:41 PM
From Mike Honey’s data, it looks like BA.3.2 is starting to take off in a few places - notably Australia and Germany.
This variant could be our next BA.2.86 (which later became the dominant JN.1).
At this time, a very possible recombination with an XFG variant could easily kick this off.
This variant could be our next BA.2.86 (which later became the dominant JN.1).
At this time, a very possible recombination with an XFG variant could easily kick this off.
Reposted by Patrickthebiosteamist
BA.3.2.2 arrived in Ireland - EPI_ISL_20259113
🎃
🎃
November 26, 2025 at 7:00 PM
BA.3.2.2 arrived in Ireland - EPI_ISL_20259113
🎃
🎃
Reposted by Patrickthebiosteamist
Fascinating 🧵. The grotesquely mutated spike of this NJ Cryptic binds ACE2 very tightly.
It raises a broader question: Can cryptic wastewater-like lineages transmit?
YES
We knew it happened once. Now we know it's happened at least twice. The results in both cases were not pretty. 1/15
It raises a broader question: Can cryptic wastewater-like lineages transmit?
YES
We knew it happened once. Now we know it's happened at least twice. The results in both cases were not pretty. 1/15
This is wild.
Remember the NJ crytic lineage?
I posted 18 months ago that the Spike was too divergent to predict ACE2 binding, and asked if someone else could figure it out.
Some colleagues took me up on it.
Guess what they found?
1/
Remember the NJ crytic lineage?
I posted 18 months ago that the Spike was too divergent to predict ACE2 binding, and asked if someone else could figure it out.
Some colleagues took me up on it.
Guess what they found?
1/
November 22, 2025 at 7:19 PM
Fascinating 🧵. The grotesquely mutated spike of this NJ Cryptic binds ACE2 very tightly.
It raises a broader question: Can cryptic wastewater-like lineages transmit?
YES
We knew it happened once. Now we know it's happened at least twice. The results in both cases were not pretty. 1/15
It raises a broader question: Can cryptic wastewater-like lineages transmit?
YES
We knew it happened once. Now we know it's happened at least twice. The results in both cases were not pretty. 1/15
Phases of Covid Infection - Part 1
youtu.be/rLOJm8dNbvU
youtu.be/rLOJm8dNbvU
Phases of Covid Infection - Part 1
YouTube video by PatricktheBioSTEAMist
youtu.be
November 22, 2025 at 9:18 PM
Phases of Covid Infection - Part 1
youtu.be/rLOJm8dNbvU
youtu.be/rLOJm8dNbvU
Zohran Mamdani and I are the same age.
So for the New Yorkers out there.
Once more I say…
Mask for Mamdani! 😷
So for the New Yorkers out there.
Once more I say…
Mask for Mamdani! 😷
November 22, 2025 at 3:41 PM
Zohran Mamdani and I are the same age.
So for the New Yorkers out there.
Once more I say…
Mask for Mamdani! 😷
So for the New Yorkers out there.
Once more I say…
Mask for Mamdani! 😷
Reposted by Patrickthebiosteamist
This is wild.
Remember the NJ crytic lineage?
I posted 18 months ago that the Spike was too divergent to predict ACE2 binding, and asked if someone else could figure it out.
Some colleagues took me up on it.
Guess what they found?
1/
Remember the NJ crytic lineage?
I posted 18 months ago that the Spike was too divergent to predict ACE2 binding, and asked if someone else could figure it out.
Some colleagues took me up on it.
Guess what they found?
1/
November 21, 2025 at 3:19 PM
This is wild.
Remember the NJ crytic lineage?
I posted 18 months ago that the Spike was too divergent to predict ACE2 binding, and asked if someone else could figure it out.
Some colleagues took me up on it.
Guess what they found?
1/
Remember the NJ crytic lineage?
I posted 18 months ago that the Spike was too divergent to predict ACE2 binding, and asked if someone else could figure it out.
Some colleagues took me up on it.
Guess what they found?
1/
I know I’ve got several different on-going educational series, but what’s one more!
Going to start a video series later today breaking down everything that goes into a Covid infection from acute infection to the potential of long Covid - from a conceptual level with simple hand drawn figures
Going to start a video series later today breaking down everything that goes into a Covid infection from acute infection to the potential of long Covid - from a conceptual level with simple hand drawn figures
November 21, 2025 at 5:39 PM
I know I’ve got several different on-going educational series, but what’s one more!
Going to start a video series later today breaking down everything that goes into a Covid infection from acute infection to the potential of long Covid - from a conceptual level with simple hand drawn figures
Going to start a video series later today breaking down everything that goes into a Covid infection from acute infection to the potential of long Covid - from a conceptual level with simple hand drawn figures
To those of us that have been following Covid and Long Covid, it is not a surprise to see rampant misinfo on the CDC pages.
With the autism/vaccine page, know this is not their first instance of this, it’s just the first time you have taken notice or care of it.
It’s not too late to mask up 😷
With the autism/vaccine page, know this is not their first instance of this, it’s just the first time you have taken notice or care of it.
It’s not too late to mask up 😷
The CDC updated its vaccine page to claim "vaccines do not cause autism" is "not evidence-based" and studies were "ignored." This is an outrage. Decades of research have found no link. This isn't science, it's RFK Jr. using the CDC as propaganda. Children will die because of this.
November 20, 2025 at 4:39 PM
To those of us that have been following Covid and Long Covid, it is not a surprise to see rampant misinfo on the CDC pages.
With the autism/vaccine page, know this is not their first instance of this, it’s just the first time you have taken notice or care of it.
It’s not too late to mask up 😷
With the autism/vaccine page, know this is not their first instance of this, it’s just the first time you have taken notice or care of it.
It’s not too late to mask up 😷
To those of us that have been following Covid and Long Covid, it is not a surprise to see rampant misinfo on the CDC pages.
With the autism/vaccine page, know this is not their first instance of this, it’s just the first time you have taken notice or care of it.
It’s not too late to mask up 😷
With the autism/vaccine page, know this is not their first instance of this, it’s just the first time you have taken notice or care of it.
It’s not too late to mask up 😷
November 20, 2025 at 4:28 PM
To those of us that have been following Covid and Long Covid, it is not a surprise to see rampant misinfo on the CDC pages.
With the autism/vaccine page, know this is not their first instance of this, it’s just the first time you have taken notice or care of it.
It’s not too late to mask up 😷
With the autism/vaccine page, know this is not their first instance of this, it’s just the first time you have taken notice or care of it.
It’s not too late to mask up 😷
Reposted by Patrickthebiosteamist
Robert Malone says the MMWR -- the CDC's venerated journal -- is being scaled back. He also says he is now the chair of the influenza vaccine working group.
November 20, 2025 at 3:08 AM
Robert Malone says the MMWR -- the CDC's venerated journal -- is being scaled back. He also says he is now the chair of the influenza vaccine working group.
ACIP is having a last minute December meeting covering the childhood vaccine schedule, “adjuvants and contaminants”, and the Hep B vaccine.
Public comment ends in 5 days.
Public comment ends in 5 days.
If anyone would like to submit a written comment to the ACIP for the upcoming meeting on December 4/5 here is the link. Comments are open until 11/24/25.
I already submitted one regarding Hep B prior to the news about the CDC vaccine website changes from today.
www.regulations.gov/commenton/CD...
I already submitted one regarding Hep B prior to the news about the CDC vaccine website changes from today.
www.regulations.gov/commenton/CD...
Regulations.gov
www.regulations.gov
November 20, 2025 at 5:17 AM
ACIP is having a last minute December meeting covering the childhood vaccine schedule, “adjuvants and contaminants”, and the Hep B vaccine.
Public comment ends in 5 days.
Public comment ends in 5 days.
Reposted by Patrickthebiosteamist
Tracking SARSCoV2 Lineage BA.3.2* over time | 11/19/2025 update
Total BA.3.2* sequences: 91
Countries reporting BA.3.2*: #Australia, #SouthAfrica, #Netherlands, #USA (traveler seq), #Germany, #Mozambique, #Slovenia, #UK, #Denmark
Tracker: public.tableau.com/app/profile/...
Total BA.3.2* sequences: 91
Countries reporting BA.3.2*: #Australia, #SouthAfrica, #Netherlands, #USA (traveler seq), #Germany, #Mozambique, #Slovenia, #UK, #Denmark
Tracker: public.tableau.com/app/profile/...
November 20, 2025 at 4:14 AM
Tracking SARSCoV2 Lineage BA.3.2* over time | 11/19/2025 update
Total BA.3.2* sequences: 91
Countries reporting BA.3.2*: #Australia, #SouthAfrica, #Netherlands, #USA (traveler seq), #Germany, #Mozambique, #Slovenia, #UK, #Denmark
Tracker: public.tableau.com/app/profile/...
Total BA.3.2* sequences: 91
Countries reporting BA.3.2*: #Australia, #SouthAfrica, #Netherlands, #USA (traveler seq), #Germany, #Mozambique, #Slovenia, #UK, #Denmark
Tracker: public.tableau.com/app/profile/...
I’m nervous about this new classification scheme NY is doing now that they’ve transitioned to a new method of quantifying Covid in the wastewater.
Regions that I have rarely seen low (like the Long Island area) are now consistently low.
I worry this is an artifact of their new classifications
Regions that I have rarely seen low (like the Long Island area) are now consistently low.
I worry this is an artifact of their new classifications
November 18, 2025 at 9:01 PM
I’m nervous about this new classification scheme NY is doing now that they’ve transitioned to a new method of quantifying Covid in the wastewater.
Regions that I have rarely seen low (like the Long Island area) are now consistently low.
I worry this is an artifact of their new classifications
Regions that I have rarely seen low (like the Long Island area) are now consistently low.
I worry this is an artifact of their new classifications
Reposted by Patrickthebiosteamist
two new BA.3.2.2 from NSW clustering with previous samples from there, likely local circualtion has started:
nextstrain.org/fetch/genome...
nextstrain.org/fetch/genome...
nextstrain.org
November 17, 2025 at 9:27 AM
two new BA.3.2.2 from NSW clustering with previous samples from there, likely local circualtion has started:
nextstrain.org/fetch/genome...
nextstrain.org/fetch/genome...
Reposted by Patrickthebiosteamist
Our recent study on BA.3.2 is now available. Thanks to Markus Hoffmann, Lu Zhang and Georg Behrens for the great collaboration. Here’s a brief summary of our findings:
November 17, 2025 at 10:55 AM
Our recent study on BA.3.2 is now available. Thanks to Markus Hoffmann, Lu Zhang and Georg Behrens for the great collaboration. Here’s a brief summary of our findings: