Nurdan Kuru
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nurdankuru.bsky.social
Nurdan Kuru
@nurdankuru.bsky.social
Postdoc at Siepel Lab, CSHL
Statistical genetics, phylogenetics, and optimization
Our new algorithm PHACE: Phylogeny-Aware Detection of Molecular Coevolution, by me and Ogün Adebali (@compgenomics.bsky.social), is now published in Molecular Biology and Evolution.

Many thanks to @nehircanozdemir.bsky.social for the beautiful illustration of PHACE!
@nurdankuru.bsky.social & Adebali present PHACE, a phylogeny-aware coevolution algorithm that maps amino acid substitutions onto a phylogenetic tree to detect molecular coevolution.

🔗 doi.org/10.1093/molbev/msaf150

#evobio #molbio #phylogenetics
July 18, 2025 at 3:10 PM
Reposted by Nurdan Kuru
Coming up on August 5 🗓️
Nurdan Kuru @nurdankuru.bsky.social shares phylogeny-aware methods for variant effect prediction.
Ferdy van Geest dives into MCT8 variants & thyroid disease. Computational meets clinical! #Genetics #RareDisease #MedicalGenetics ℹ️ www.varianteffect.org/seminar-seri...
July 15, 2025 at 8:22 PM
#BoG25 at home - CSHL
May 11, 2025 at 12:15 AM
Reposted by Nurdan Kuru
A gene called NOVA1 may be part of the solution to the mystery of how our ancestors evolved language. Here's my story about mice with strange squeaks. [Gift link] nyti.ms/3XuVehN 🧪
The Gene That Made Mice Squeak Strangely (Gift Article)
A new study suggests that the NOVA1 gene may have been a key player in the evolution of human language.
nyti.ms
February 18, 2025 at 6:34 PM
Reposted by Nurdan Kuru
NOVA1, a neuron-specific RNA binding protein & splicing factor, likely impacted language function in human evolution. Human NOVA1 is unique (vs mammals, Neanderthals), & it changes vocalization in CRISPR’d mice!

TY @NatureComms @RockefellerUniv team, collaborators @erichjarvis @asiepel labs

🧵👇
February 18, 2025 at 4:32 PM