Moritz Mall
@moritzmall.bsky.social
Research group leader @German Cancer Research Center, reconstructing human development and disease using cell fate engineering
Thank you @gscnoffice.bsky.social and the selection committee for the GSCN 2025 Best Publication Award recognizing our joint work: www.nature.com/articles/s41... Proud of the team & all co-authors. Grateful to @dkfz.bsky.social and @embl.org for the support. See you in Munich!
Active repression of cell fate plasticity by PROX1 safeguards hepatocyte identity and prevents liver tumorigenesis - Nature Genetics
This study identifies candidate safeguard repressor transcription factors that repress alternate lineages in mature cell types and provides functional evidence that Prox1 performs such a function in h...
www.nature.com
August 22, 2025 at 4:48 PM
Thank you @gscnoffice.bsky.social and the selection committee for the GSCN 2025 Best Publication Award recognizing our joint work: www.nature.com/articles/s41... Proud of the team & all co-authors. Grateful to @dkfz.bsky.social and @embl.org for the support. See you in Munich!
An insightful thread for the second study by the one and only @manusaraswat.bsky.social that spearheaded this superstar team effort together with @lauraruedag.bsky.social and Elisa Heinzelmann in the labs of @oliverstegle.bsky.social and me:
bsky.app/profile/manu...
bsky.app/profile/manu...
🧠 Excited to share my main PhD project! We mapped the regulatory rules governing Glioblastoma plasticity using single-cell multi-omics and deep learning. This work is part of a two-paper series with @bayraktarlab.bsky.social @oliverstegle.bsky.social and @moritzmall.bsky.social, Preprint at end🧵👇
May 16, 2025 at 3:57 PM
An insightful thread for the second study by the one and only @manusaraswat.bsky.social that spearheaded this superstar team effort together with @lauraruedag.bsky.social and Elisa Heinzelmann in the labs of @oliverstegle.bsky.social and me:
bsky.app/profile/manu...
bsky.app/profile/manu...
Detailed thread for the first study from the overall leader of this truly collaborative effort, the amazing @bayraktarlab.bsky.social: bsky.app/profile/bayr...
How does tumour heterogeneity arise? How can we predict cancer cell plasticity? In 2 new studies, we trace #glioblastoma heterogeneity to a spatial cancer cell trajectory w. multimodal cell atlassing bit.ly/4mkrWgs & predict plasticity w. snRNA/ATAC+deep learning bit.ly/3FbI6Ic 🧵
May 16, 2025 at 3:57 PM
Detailed thread for the first study from the overall leader of this truly collaborative effort, the amazing @bayraktarlab.bsky.social: bsky.app/profile/bayr...
Reposted by Moritz Mall
13/ Want to learn more? Read our regulatory paper www.biorxiv.org/content/10.1... and companion spatial multi-omics study www.biorxiv.org/content/10.1...
Watch out for thread from @bayraktarlab.bsky.social on mapping conserved spatiotemporal trajectories of GB
Watch out for thread from @bayraktarlab.bsky.social on mapping conserved spatiotemporal trajectories of GB
Decoding Plasticity Regulators and Transition Trajectories in Glioblastoma with Single-cell Multiomics
Glioblastoma (GB) is one of the most lethal human cancers, marked by profound intratumoral heterogeneity and near-universal treatment resistance. Cellular plasticity, the capacity of cancer cells to t...
www.biorxiv.org
May 16, 2025 at 10:05 AM
13/ Want to learn more? Read our regulatory paper www.biorxiv.org/content/10.1... and companion spatial multi-omics study www.biorxiv.org/content/10.1...
Watch out for thread from @bayraktarlab.bsky.social on mapping conserved spatiotemporal trajectories of GB
Watch out for thread from @bayraktarlab.bsky.social on mapping conserved spatiotemporal trajectories of GB