Marie-Julie (MJ) Favé
@mjfave.bsky.social
Associate Prof at Concordia University
Computational Genomics Lab &
Environmental Human Health
PhD. Loves data. Montrealer
Lab website: https://mariejuliefave.weebly.com/
🚲
Computational Genomics Lab &
Environmental Human Health
PhD. Loves data. Montrealer
Lab website: https://mariejuliefave.weebly.com/
🚲
Pinned
Marie-Julie (MJ) Favé
@mjfave.bsky.social
· Jun 12
🎆I am beyond thrilled that I will be joining
Concordia University Biology department in Montréal as an Associate Professor in the Fall 2024! My Computational Genomics lab will use multi-omics to understand environmental and genetic contributions to human health! 🧬
Concordia University Biology department in Montréal as an Associate Professor in the Fall 2024! My Computational Genomics lab will use multi-omics to understand environmental and genetic contributions to human health! 🧬
New preprint live! www.medrxiv.org/content/10.1...
Geography, Ancestry, Age and Sex Shape Somatic Autosomal Mosaic Chromosomal Alterations in Blood
Geography, Ancestry, Age and Sex Shape Somatic Autosomal Mosaic Chromosomal Alterations in Blood
Geography, Ancestry, Age and Sex Shape Somatic Autosomal Mosaic Chromosomal Alterations in Blood
Clonal hematopoiesis, through the age-associated accumulation of somatic mutations in blood, is strongly associated with hematological malignancies and other chronic diseases. These mutations have lar...
www.medrxiv.org
October 20, 2025 at 7:33 PM
New preprint live! www.medrxiv.org/content/10.1...
Geography, Ancestry, Age and Sex Shape Somatic Autosomal Mosaic Chromosomal Alterations in Blood
Geography, Ancestry, Age and Sex Shape Somatic Autosomal Mosaic Chromosomal Alterations in Blood
My first time awarding a PhD to a candidate, what a precious honour. Keep up the good work, students!
October 20, 2025 at 3:10 PM
My first time awarding a PhD to a candidate, what a precious honour. Keep up the good work, students!
Reposted by Marie-Julie (MJ) Favé
Now: @jsdron.bsky.social (JD): Age- and BMI-dependent genetic architecture of blood lipids in 2.5 million individuals from globally diverse populations #ASHG25 🧪🧬🖥️
October 17, 2025 at 10:02 PM
Now: @jsdron.bsky.social (JD): Age- and BMI-dependent genetic architecture of blood lipids in 2.5 million individuals from globally diverse populations #ASHG25 🧪🧬🖥️
Reposted by Marie-Julie (MJ) Favé
We're excited to be recruiting an NIH funded postdoc to work in the Coop lab at UC Davis. We're specifically interested in candidates who are want to work at the intersection of human genetics, GWAS, and population genetics modeling. Please RT
October 15, 2025 at 3:53 PM
We're excited to be recruiting an NIH funded postdoc to work in the Coop lab at UC Davis. We're specifically interested in candidates who are want to work at the intersection of human genetics, GWAS, and population genetics modeling. Please RT
Come join us in beautiful vibrant Montréal! Job opening for a CRC position in Applied Synthetic Biology at Concordia University. www.concordia.ca/jobs/artsci/... #ASHG25 #ASHG2025
Canada Research Chair Tier II in Applied Synthetic Biology | Faculty of Arts and Science - Concordia University
The Department of Biology in the Faculty of Arts and Science at Concordia University invites applications for a tenure track faculty position and Tier II Canada Research Chair (CRC) in Applied Synthet...
www.concordia.ca
October 15, 2025 at 1:23 PM
Come join us in beautiful vibrant Montréal! Job opening for a CRC position in Applied Synthetic Biology at Concordia University. www.concordia.ca/jobs/artsci/... #ASHG25 #ASHG2025
Reposted by Marie-Julie (MJ) Favé
Ever wondered how robust cellular identity is to external perturbations? Here we disrupt cellular environmnent in vivo and in vitro, and find cell population specific sensitivities. Environment sculpts development yes, but not all cells are made of the same wood. www.science.org/doi/10.1126/...
Cell-extrinsic controls over neocortical neuron fate and diversity
Cell-extrinsic cues are key for neocortical cell identity and diversity.
www.science.org
September 19, 2025 at 6:04 AM
Ever wondered how robust cellular identity is to external perturbations? Here we disrupt cellular environmnent in vivo and in vitro, and find cell population specific sensitivities. Environment sculpts development yes, but not all cells are made of the same wood. www.science.org/doi/10.1126/...
Reposted by Marie-Julie (MJ) Favé
Interesting, well-written article from the Guardian.
www.theguardian.com/world/2025/a...
www.theguardian.com/world/2025/a...
Arctic glaciers face ‘terminal’ decline as microbes accelerate ice melt
Scientists in Svalbard in race to study polar microbes as global heating threatens fragile glacial ecosystems
www.theguardian.com
August 15, 2025 at 11:23 AM
Interesting, well-written article from the Guardian.
www.theguardian.com/world/2025/a...
www.theguardian.com/world/2025/a...
Reposted by Marie-Julie (MJ) Favé
Music to my ears. This is brilliant. Either 90% of us can claim to be better musicians than Beethoven or… maybe just maybe polygenic scores aren’t perfect?
If someone you know buys into claims about "genetic optimization" of embryos using polygenic scores of cognition, just send them our 2024 paper on Beethoven & musicality. We wrote it to help communicate limits of individual-level genetic predictions & complexity of links between DNA & behaviour. 🧪👇
Notes from Beethoven’s genome
Wesseldijk et al. compare the genomic information collected from Ludwig van Beethoven
with population-based datasets used to quantify musical achievement.
www.cell.com
August 15, 2025 at 4:14 AM
Music to my ears. This is brilliant. Either 90% of us can claim to be better musicians than Beethoven or… maybe just maybe polygenic scores aren’t perfect?
Reposted by Marie-Julie (MJ) Favé
Nature research paper: Multigenerational cell tracking of DNA replication and heritable DNA damage
https://go.nature.com/4jxWDMJ
https://go.nature.com/4jxWDMJ
Multigenerational cell tracking of DNA replication and heritable DNA damage - Nature
A multigenerational single-cell tracking approach provides a framework to dissect phenotypic plasticity at the single-cell level, offering insights into cellular processes that may resemble early events during cancer development.
go.nature.com
May 23, 2025 at 12:31 PM
Nature research paper: Multigenerational cell tracking of DNA replication and heritable DNA damage
https://go.nature.com/4jxWDMJ
https://go.nature.com/4jxWDMJ
Reposted by Marie-Julie (MJ) Favé
Reposted by Marie-Julie (MJ) Favé
On parle souvent de l'importance de la fluidité automobile au centre-ville. Pourtant, seuls 21% des déplacements vers le centre-ville se font en voiture. On devrait plutôt parler de comment améliorer le transport collectif (55%) et actif (23%) si on veut attirer les clients et travailleurs au c-v.
May 6, 2025 at 1:49 PM
On parle souvent de l'importance de la fluidité automobile au centre-ville. Pourtant, seuls 21% des déplacements vers le centre-ville se font en voiture. On devrait plutôt parler de comment améliorer le transport collectif (55%) et actif (23%) si on veut attirer les clients et travailleurs au c-v.
Reposted by Marie-Julie (MJ) Favé
Come join us at @mcgill.ca as an assistant professor in virus-host interactions! Please share widely.
mcgill.wd3.myworkdayjobs.com/en-US/McGill...
mcgill.wd3.myworkdayjobs.com/en-US/McGill...
Assistant Professor (Research), Department of Microbiology & Immunology, (C2-240724)
Please refer to the How to Apply for a Job (for External Candidates) job aid for instructions on how to apply. If you are an active McGill employee (ie: currently in an active contract or position at ...
mcgill.wd3.myworkdayjobs.com
April 24, 2025 at 8:17 PM
Come join us at @mcgill.ca as an assistant professor in virus-host interactions! Please share widely.
mcgill.wd3.myworkdayjobs.com/en-US/McGill...
mcgill.wd3.myworkdayjobs.com/en-US/McGill...
Getting mistaken for a student at my final exam ✅
Should I have pretended and write my own exam? 😁
Should I have pretended and write my own exam? 😁
April 23, 2025 at 10:42 PM
Getting mistaken for a student at my final exam ✅
Should I have pretended and write my own exam? 😁
Should I have pretended and write my own exam? 😁
This morning, teaching an undergraduate class in population genetics gave me hope and confidence for the future, those students are rocking it!!
March 13, 2025 at 3:49 PM
This morning, teaching an undergraduate class in population genetics gave me hope and confidence for the future, those students are rocking it!!
Reposted by Marie-Julie (MJ) Favé
To the women in science. To the allies in science. To the ones who lift each other up.
I spend my life in science, constantly trying to figure out where I fit in. At times, it feels like pushing against an invisible force-one that questions, doubts, resists. But through it all, I am never alone. 🧵
I spend my life in science, constantly trying to figure out where I fit in. At times, it feels like pushing against an invisible force-one that questions, doubts, resists. But through it all, I am never alone. 🧵
February 12, 2025 at 11:07 PM
To the women in science. To the allies in science. To the ones who lift each other up.
I spend my life in science, constantly trying to figure out where I fit in. At times, it feels like pushing against an invisible force-one that questions, doubts, resists. But through it all, I am never alone. 🧵
I spend my life in science, constantly trying to figure out where I fit in. At times, it feels like pushing against an invisible force-one that questions, doubts, resists. But through it all, I am never alone. 🧵
Sex determination in cephalopods: hemizygosity (ZO) in females and ZZ males, and predates the radiation of the group 480 milions years ago. Fascinating work by Andrew Kern lab!
Cephalopod sex determination and its ancient evolutionary origin
Coffing et al. assemble a chromosome-level octopus genome assembly, revealing that
the female octopus has just one sex chromosome (ZO karyotype), and males have two
(ZZ karyotype). They conduct genomi...
www.cell.com
February 11, 2025 at 1:55 PM
Sex determination in cephalopods: hemizygosity (ZO) in females and ZZ males, and predates the radiation of the group 480 milions years ago. Fascinating work by Andrew Kern lab!
Reposted by Marie-Julie (MJ) Favé
Our blood tests are interpreted by average reference values. That's missing a lot of rich information!
Each person has their own tightly regulated setpoints. One healthy person's complete blood count setpoint can be differentiated from 98% of other healthy adults.
www.nature.com/articles/s41...
Each person has their own tightly regulated setpoints. One healthy person's complete blood count setpoint can be differentiated from 98% of other healthy adults.
www.nature.com/articles/s41...
December 11, 2024 at 4:18 PM
Our blood tests are interpreted by average reference values. That's missing a lot of rich information!
Each person has their own tightly regulated setpoints. One healthy person's complete blood count setpoint can be differentiated from 98% of other healthy adults.
www.nature.com/articles/s41...
Each person has their own tightly regulated setpoints. One healthy person's complete blood count setpoint can be differentiated from 98% of other healthy adults.
www.nature.com/articles/s41...
When even your office phone knows you only as per your initials. #LongNameProblems
December 6, 2024 at 7:51 PM
When even your office phone knows you only as per your initials. #LongNameProblems
Hybridization lead to a reduced rate of LOH and influence
adaptation - Very cool work by the Landry lab!
adaptation - Very cool work by the Landry lab!
For her PhD work, Carla Bautista in our group discovered that yeast hybrids adapted slower to stressful conditions, and she figured out why. See what she found here. #evolution www.nature.com/articles/s41...
Hybrid adaptation is hampered by Haldane’s sieve - Nature Communications
Hybrids have complex genomes that influence their adaptive potential. This study reveals that yeast hybrids adapt slower than their parental species in a new environment, primarily due to a reduced ra...
www.nature.com
December 4, 2024 at 1:29 PM
Hybridization lead to a reduced rate of LOH and influence
adaptation - Very cool work by the Landry lab!
adaptation - Very cool work by the Landry lab!
Reposted by Marie-Julie (MJ) Favé
Scientists, academics, researchers: We’re excited to share that @altmetric.com is now tracking mentions of your research on Bluesky! 🧪
There are already many articles for which there is more attention on Bluesky than on other comparable micro-blogging sites, meaning the academic community and the general public have clearly adopted Bluesky as one of its core places to disseminate and discuss new research.
A Place of Joy.
A Place of Joy.
December 3, 2024 at 2:10 PM
Scientists, academics, researchers: We’re excited to share that @altmetric.com is now tracking mentions of your research on Bluesky! 🧪
Reposted by Marie-Julie (MJ) Favé
Does my mutation have the same impact as yours? Population genetics 🤠 🥸 🤓 🤡 meets single cell CRISPRi ⚡ ! www.biorxiv.org/content/10.1... Led by Claudia Feng, Oliver Stegle, Britta Velten, @sangerinstitute.bsky.social .
LinkedIn
This link will take you to a page that’s not on LinkedIn
lnkd.in
December 2, 2024 at 1:57 PM
Does my mutation have the same impact as yours? Population genetics 🤠 🥸 🤓 🤡 meets single cell CRISPRi ⚡ ! www.biorxiv.org/content/10.1... Led by Claudia Feng, Oliver Stegle, Britta Velten, @sangerinstitute.bsky.social .
Reposted by Marie-Julie (MJ) Favé
October 27, 2024 at 12:50 PM
LoF and duplications correlated effects on phenotypes lead to an interesting paradox:
In a new preprint led by @TheNikhilMilind, we explored a fascinating paradox:
For many traits the number of duplications or loss-of-function (LoF) mutations is correlated with phenotype. Curiously, for most traits, the AVERAGE direction of LoFs and Dups is the SAME. Why?
For many traits the number of duplications or loss-of-function (LoF) mutations is correlated with phenotype. Curiously, for most traits, the AVERAGE direction of LoFs and Dups is the SAME. Why?
November 24, 2024 at 1:40 AM
LoF and duplications correlated effects on phenotypes lead to an interesting paradox:
Reposted by Marie-Julie (MJ) Favé
Every year, >200K newborns die from sepsis.
Our team used machine learning to develop a set of genes that can predict neonatal sepsis risk using at birth blood samples.
www.thelancet.com/journals/ebi...
Predictive gene expression signature diagnoses neonatal sepsis before clinical presentation
Despite appearing healthy at birth, neonates who later developed EOS already had distinct
whole blood gene expression changes at birth, which enabled the development of a 4-gene
predictive signature f...
www.thelancet.com
November 21, 2024 at 9:16 AM
Every year, >200K newborns die from sepsis.
Our team used machine learning to develop a set of genes that can predict neonatal sepsis risk using at birth blood samples.
www.thelancet.com/journals/ebi...