Nature Metabolism, Published online: 01 December 2025; doi:10.1038/s42255-025-01405-8Non-nutritive sensory components of high-fat diet, such as bacon flavour, are sufficient to impair metabolic health in offspring in mice.

Nature Metabolism, Published online: 08 December 2025; doi:10.1038/s42255-025-01413-8The microbial metabolite trimethylamine (TMA), the precursor of TMAO, which is associated with adverse cardiometabolic outcomes, is shown to have beneficial metabolic and anti-inflammatory effects in the host in the context of obesity.

The microbial metabolite trimethylamine (TMA), the precursor of TMAO, which is associated with adverse cardiometabolic outcomes, is shown to have beneficial metabolic and anti-inflammatory effects in ...

The microbial metabolite trimethylamine (TMA), the precursor of TMAO, which is associated with adverse cardiometabolic outcomes, is shown to have beneficial metabolic and anti-inflammatory effects in ...

In this video interview, Dr. Mireia Vallès-Colomer explains how our microbiome is formed, shared, and transmitted throughout life — and why understanding these microbial connections is key for human and planetary health.

More children and adults are being diagnosed with ADHD in some countries. Science is helping to understand why — and how best to provide support.

Systematic analysis and machine learning coupled with in vitro and in vivo validation link gut microbiome-mediated transformation of dietary phytonutrients to health outcomes.

This Consensus Statement presents the standards for technical reporting in environmental and host-associated microbiome studies (STREAMS) guidelines.

A recent study reported that imidazole propionate made by gut bacteria contributes to atherosclerosis development, supporting its potential role as a biomarker of subclinical disease.

Chronic cold stress in Glp1r-/-Gipr-/-, Glp1r-/-Glp2r-/-, and Glp2r-/- mice revealed distinct and overlapping roles for GLP-1R and GLP-2R in the expansion of the intestinal absorptive surface area exp...

Nature Metabolism, Published online: 24 November 2025; doi:10.1038/s42255-025-01414-7We show that the size of the mitochondrial NAD+ pool in hepatocytes is regulated by SLC25A51 expression in vivo. We further find that selectively increasing mitochondrial NAD+ is sufficient to improve liver regeneration after partial hepatectomy, equivalent to the effect of systemic high-dose NAD+ precursor supplementation.

Quantifying metabolic activity in patient tumors could advance personalized cancer targeting. Meghdadi et al. develop a digital twin framework using machine learning to quantify metabolic fluxes in tissues from patients with glioma, identifying which patients may benefit from different targeted metabolic therapies like specialized diets or pharmacologic agents.

Nature Metabolism, Published online: 01 December 2025; doi:10.1038/s42255-025-01405-8Non-nutritive sensory components of high-fat diet, such as bacon flavour, are sufficient to impair metabolic health in offspring in mice.

The microprotein adipogenin (Adig) is predominantly expressed in adipose tissues. Here, we found that Adig interacts with seipin to form a stable, rigid complex. We present the structure of the seipin...

Introduction Patients with intestinal failure caused by short bowel syndrome (SBS) are dependent on parenteral support (PS) for nutrition. Teduglutide, an analogue of glucagon-like peptide 2, has been...

In this Review, the authors present a roadmap towards achieving consensus on development, analysis and interpretation of single-cell transcriptomics data in adipose tissue, including discussion of roadblocks, best practices and ideal cell-type markers for annotation of adipose tissue cell types in mice and humans.

FFAR4 is a lipid-sensing GPCR with pivotal roles in metabolic regulation and inflammation resolution. This review by Kong et al. integrates recent structural insights into FFAR4 activation, its expand...

Pathway analysis, originally developed for gene expression data, has been adapted for metabolomics. However, owing to the unique characteristics and constraints of metabolites compared with genes, pathway analysis in metabolomics often yields misleading or nonsensical results.

Growing evidence from the microbiome field shows that harnessing gut microbes through diet can beneficially impact brain and behaviour. Which gut microbiome-targeted interventions have been studied as potential approaches for mental health?