Michael P Hart 🏳️🌈 (he/him)
@michaelphart1.bsky.social
Neuroscientist and geneticist @PennGenetics and @PennMedicine. Our lab studies plasticity of neuronal circuits and behavior in C. elegans. www.mphartlab.com
And together with work from Serena Ding on variation of the behavior in wild C elegans isolate strains, completes a survey of social feeding in our favorite nematodes! www.biorxiv.org/content/10.1...
Natural variation in Caenorhabditis elegans collective behavior reveals potential adaptation to novel environments
Recent advances in quantitative approaches to behavior have enabled rigorous trait measurements that allow us to understand how behavior evolves in multiple taxa([1][1]–[7][2]). However, placing these...
www.biorxiv.org
November 19, 2025 at 3:57 PM
And together with work from Serena Ding on variation of the behavior in wild C elegans isolate strains, completes a survey of social feeding in our favorite nematodes! www.biorxiv.org/content/10.1...
This new work gives broader context for @maracowen.bsky.social's paper on social feeding and conserved autism genes in C. elegans!
rdcu.be/eQMoB
rdcu.be/eQMoB
Conserved autism-associated genes tune social feeding behavior in C. elegans
Nature Communications - C. elegans aggregate in large clumps during feeding. Here, the authors find conserved autism-associated genes mediate distinct molecular and circuit signaling components...
rdcu.be
November 19, 2025 at 3:57 PM
This new work gives broader context for @maracowen.bsky.social's paper on social feeding and conserved autism genes in C. elegans!
rdcu.be/eQMoB
rdcu.be/eQMoB
Amazing!! Should blow it up and frame it!!
October 30, 2025 at 9:27 PM
Amazing!! Should blow it up and frame it!!
Also thrilled to continue an awesome collaboration with
@camarapg.bsky.social (@penngenetics.bsky.social) using the #CAJAL algorithm to analyze >1000 DVB neuron reconstructions from the screen!! (original CAJAL paper = doi.org/10.1038/s41467-023-39424-2)
@camarapg.bsky.social (@penngenetics.bsky.social) using the #CAJAL algorithm to analyze >1000 DVB neuron reconstructions from the screen!! (original CAJAL paper = doi.org/10.1038/s41467-023-39424-2)
CAJAL enables analysis and integration of single-cell morphological data using metric geometry - Nature Communications
Cell morphology is one of the most described phenotypes in biology, yet systematic quantification and classification of morphology remains limited. Here, the authors present a computational approach f...
doi.org
August 13, 2025 at 10:14 PM
Also thrilled to continue an awesome collaboration with
@camarapg.bsky.social (@penngenetics.bsky.social) using the #CAJAL algorithm to analyze >1000 DVB neuron reconstructions from the screen!! (original CAJAL paper = doi.org/10.1038/s41467-023-39424-2)
@camarapg.bsky.social (@penngenetics.bsky.social) using the #CAJAL algorithm to analyze >1000 DVB neuron reconstructions from the screen!! (original CAJAL paper = doi.org/10.1038/s41467-023-39424-2)
Stay tuned for follow-up mechanistic work exploring H4K20 methylation as a regulator of neuron remodeling involving set-4 (KMT5B), and a bunch of conserved synaptic genes!!
August 13, 2025 at 10:10 PM
Stay tuned for follow-up mechanistic work exploring H4K20 methylation as a regulator of neuron remodeling involving set-4 (KMT5B), and a bunch of conserved synaptic genes!!
Awesome, excited to see it @ethanewe.bsky.social !!
August 11, 2025 at 12:59 PM
Awesome, excited to see it @ethanewe.bsky.social !!
🔗 Check out the full paper:
www.cell.com/ajhg/fulltex...
📢 Read the Science coverage:
www.science.org/content/arti...
💙 Excited to keep pushing this conversation forward!
www.cell.com/ajhg/fulltex...
📢 Read the Science coverage:
www.science.org/content/arti...
💙 Excited to keep pushing this conversation forward!
www.cell.com
July 14, 2025 at 9:58 PM
🔗 Check out the full paper:
www.cell.com/ajhg/fulltex...
📢 Read the Science coverage:
www.science.org/content/arti...
💙 Excited to keep pushing this conversation forward!
www.cell.com/ajhg/fulltex...
📢 Read the Science coverage:
www.science.org/content/arti...
💙 Excited to keep pushing this conversation forward!
Reposted by Michael P Hart 🏳️🌈 (he/him)
(5/5)
🚨 It’s time to flood the zone.
NIH scientists just took a huge risk speaking out. Now it’s our turn.
📜 Read the Bethesda Declaration
✍️ Sign the Public Letter of Support
👯♀️Follow NIHers doing the work: @nihvigils.bsky.social
Read and sign here 👉 www.standupforscience.net/bethesda-dec...
🚨 It’s time to flood the zone.
NIH scientists just took a huge risk speaking out. Now it’s our turn.
📜 Read the Bethesda Declaration
✍️ Sign the Public Letter of Support
👯♀️Follow NIHers doing the work: @nihvigils.bsky.social
Read and sign here 👉 www.standupforscience.net/bethesda-dec...
www.standupforscience.net
June 9, 2025 at 12:06 PM
(5/5)
🚨 It’s time to flood the zone.
NIH scientists just took a huge risk speaking out. Now it’s our turn.
📜 Read the Bethesda Declaration
✍️ Sign the Public Letter of Support
👯♀️Follow NIHers doing the work: @nihvigils.bsky.social
Read and sign here 👉 www.standupforscience.net/bethesda-dec...
🚨 It’s time to flood the zone.
NIH scientists just took a huge risk speaking out. Now it’s our turn.
📜 Read the Bethesda Declaration
✍️ Sign the Public Letter of Support
👯♀️Follow NIHers doing the work: @nihvigils.bsky.social
Read and sign here 👉 www.standupforscience.net/bethesda-dec...