Mike Clark
@michaelbclark.bsky.social
Genetics, transcriptomics, RNA and neuroscience.
Lab head at the University of Melbourne, Australia.
View own.
Lab head at the University of Melbourne, Australia.
View own.
Hard to know for sure until NHMRC releases funding details. From the grants I reviewed I think requested funds have increased as cost of research has gone up. Clearly funding available hasn't kept pace to even maintain the poor success rate we previously had.
November 26, 2025 at 9:45 PM
Hard to know for sure until NHMRC releases funding details. From the grants I reviewed I think requested funds have increased as cost of research has gone up. Clearly funding available hasn't kept pace to even maintain the poor success rate we previously had.
It's an all time low in both the percentage and number of #NHMRC #IdeasGrant funded. Previous lowest percentage was 9.8% in the 2020. However 283 grants were funded that year, this year it's under 200.
November 26, 2025 at 10:50 AM
It's an all time low in both the percentage and number of #NHMRC #IdeasGrant funded. Previous lowest percentage was 9.8% in the 2020. However 283 grants were funded that year, this year it's under 200.
Individual outcomes aren't publicly released yet, but all applicants have been told if they were successful or not
November 26, 2025 at 10:41 AM
Individual outcomes aren't publicly released yet, but all applicants have been told if they were successful or not
This project was led by the talented @jakobschuster.bsky.social in colab with @qgouil.bsky.social & @mritchieau.bsky.social
As an example of the power of Matchbox, Jakob’s last tool was Restrander. A 17 line matchbox script achieved the same result as 1400 lines of C++ in Restrander!
As an example of the power of Matchbox, Jakob’s last tool was Restrander. A 17 line matchbox script achieved the same result as 1400 lines of C++ in Restrander!
November 26, 2025 at 2:03 AM
This project was led by the talented @jakobschuster.bsky.social in colab with @qgouil.bsky.social & @mritchieau.bsky.social
As an example of the power of Matchbox, Jakob’s last tool was Restrander. A 17 line matchbox script achieved the same result as 1400 lines of C++ in Restrander!
As an example of the power of Matchbox, Jakob’s last tool was Restrander. A 17 line matchbox script achieved the same result as 1400 lines of C++ in Restrander!
We’ve demonstrated Matchbox for demultiplexing long-read scRNA-seq data with 10X or SPLiT-seq barcodes; restranding RNA-seq reads; assessing CRISPR editing efficiency; and haplotyping repeat regions.
Matchbox is implemented in rust and available from github.com/jakob-schust....
Matchbox is implemented in rust and available from github.com/jakob-schust....
November 26, 2025 at 2:03 AM
We’ve demonstrated Matchbox for demultiplexing long-read scRNA-seq data with 10X or SPLiT-seq barcodes; restranding RNA-seq reads; assessing CRISPR editing efficiency; and haplotyping repeat regions.
Matchbox is implemented in rust and available from github.com/jakob-schust....
Matchbox is implemented in rust and available from github.com/jakob-schust....
Agreed. And thanks for giving such a clear and engaging talk. Not my field but I definitely learnt a few things.
November 25, 2025 at 1:45 PM
Agreed. And thanks for giving such a clear and engaging talk. Not my field but I definitely learnt a few things.
This study reflects years of work, a big thanks to everyone involved, including Ricardo De Paoli-Iseppi who co-led the work and the many graduate and undergrad students who took on some of the genes for their projects or worked on IsoLamp including @josiegleeson.bsky.social & @youyupei.bsky.social
October 3, 2025 at 4:18 AM
This study reflects years of work, a big thanks to everyone involved, including Ricardo De Paoli-Iseppi who co-led the work and the many graduate and undergrad students who took on some of the genes for their projects or worked on IsoLamp including @josiegleeson.bsky.social & @youyupei.bsky.social
Research has shown genetic risk for disease can be imparted at the isoform level, as well as the gene level. Therefore, understanding which isoforms genes express is essential to correctly determining the disease-associated isoforms and the molecular mechanisms behind disease aetiology.
October 3, 2025 at 4:18 AM
Research has shown genetic risk for disease can be imparted at the isoform level, as well as the gene level. Therefore, understanding which isoforms genes express is essential to correctly determining the disease-associated isoforms and the molecular mechanisms behind disease aetiology.