Michael Honigberg
@mchonig.bsky.social
Cardiologist and researcher at Mass General / Broad Institute / Harvard Med. Preventive cardiology, women’s health, genomics. https://honigberglab.mgh.harvard.edu/
(6/X)
Our findings suggest CHIP remains relevant into later life & underscore its heterogeneity.
Paper (OA): www.jacc.org/doi/10.1016/...
Editorial: www.jacc.org/doi/10.1016/...
Come see @danielezzat.bsky.social 's presentation #ESC2025 (29 Aug 10:15a)!
@mghcvrc.bsky.social @broadinstitute.org
Our findings suggest CHIP remains relevant into later life & underscore its heterogeneity.
Paper (OA): www.jacc.org/doi/10.1016/...
Editorial: www.jacc.org/doi/10.1016/...
Come see @danielezzat.bsky.social 's presentation #ESC2025 (29 Aug 10:15a)!
@mghcvrc.bsky.social @broadinstitute.org
August 27, 2025 at 2:43 PM
(6/X)
Our findings suggest CHIP remains relevant into later life & underscore its heterogeneity.
Paper (OA): www.jacc.org/doi/10.1016/...
Editorial: www.jacc.org/doi/10.1016/...
Come see @danielezzat.bsky.social 's presentation #ESC2025 (29 Aug 10:15a)!
@mghcvrc.bsky.social @broadinstitute.org
Our findings suggest CHIP remains relevant into later life & underscore its heterogeneity.
Paper (OA): www.jacc.org/doi/10.1016/...
Editorial: www.jacc.org/doi/10.1016/...
Come see @danielezzat.bsky.social 's presentation #ESC2025 (29 Aug 10:15a)!
@mghcvrc.bsky.social @broadinstitute.org
(5/X)
HRs for CHIP were comparable or greater than those for other conventional CVD risk factors (e.g., 👇)
In addition, we examined alternate thresholds of variant allele frequency to define CHIP; associations generally ⬇️ w/ smaller clone size
HRs for CHIP were comparable or greater than those for other conventional CVD risk factors (e.g., 👇)
In addition, we examined alternate thresholds of variant allele frequency to define CHIP; associations generally ⬇️ w/ smaller clone size
August 27, 2025 at 2:39 PM
(5/X)
HRs for CHIP were comparable or greater than those for other conventional CVD risk factors (e.g., 👇)
In addition, we examined alternate thresholds of variant allele frequency to define CHIP; associations generally ⬇️ w/ smaller clone size
HRs for CHIP were comparable or greater than those for other conventional CVD risk factors (e.g., 👇)
In addition, we examined alternate thresholds of variant allele frequency to define CHIP; associations generally ⬇️ w/ smaller clone size
(4/X)
Key CHIP subtypes were associated w/ adverse CV events
Consistent w/ our prior work, TET2 CHIP associated w/ CHD & HFpEF
👀 ASXL1 CHIP ➡️ HFrEF (aHR >3)
Notably, no associations were seen when we lumped all CHIP types together, underscoring its heterogeneity
Key CHIP subtypes were associated w/ adverse CV events
Consistent w/ our prior work, TET2 CHIP associated w/ CHD & HFpEF
👀 ASXL1 CHIP ➡️ HFrEF (aHR >3)
Notably, no associations were seen when we lumped all CHIP types together, underscoring its heterogeneity
August 27, 2025 at 2:39 PM
(4/X)
Key CHIP subtypes were associated w/ adverse CV events
Consistent w/ our prior work, TET2 CHIP associated w/ CHD & HFpEF
👀 ASXL1 CHIP ➡️ HFrEF (aHR >3)
Notably, no associations were seen when we lumped all CHIP types together, underscoring its heterogeneity
Key CHIP subtypes were associated w/ adverse CV events
Consistent w/ our prior work, TET2 CHIP associated w/ CHD & HFpEF
👀 ASXL1 CHIP ➡️ HFrEF (aHR >3)
Notably, no associations were seen when we lumped all CHIP types together, underscoring its heterogeneity
(3/X)
We therefore examined ~6,700 👵👵 from the Women's Health Initiative Long Life Study (median age 80 y) and sequenced blood cells ~4,500x in each participant to accurately detect 🔍 and quantify CHIP
Women were followed for ~10 y for coronary heart disease and several secondary outcomes
👇
We therefore examined ~6,700 👵👵 from the Women's Health Initiative Long Life Study (median age 80 y) and sequenced blood cells ~4,500x in each participant to accurately detect 🔍 and quantify CHIP
Women were followed for ~10 y for coronary heart disease and several secondary outcomes
👇
August 27, 2025 at 2:37 PM
(3/X)
We therefore examined ~6,700 👵👵 from the Women's Health Initiative Long Life Study (median age 80 y) and sequenced blood cells ~4,500x in each participant to accurately detect 🔍 and quantify CHIP
Women were followed for ~10 y for coronary heart disease and several secondary outcomes
👇
We therefore examined ~6,700 👵👵 from the Women's Health Initiative Long Life Study (median age 80 y) and sequenced blood cells ~4,500x in each participant to accurately detect 🔍 and quantify CHIP
Women were followed for ~10 y for coronary heart disease and several secondary outcomes
👇
(2/X)
CHIP = aging-related acquired blood stem cell mutations that predispose to blood cancers
We + others have shown that CHIP also associates w/ ⬆️ CVD risk
But previous work suggested attenuation of associated risk in older adults, who have highest risk of both CHIP + CVD
CHIP = aging-related acquired blood stem cell mutations that predispose to blood cancers
We + others have shown that CHIP also associates w/ ⬆️ CVD risk
But previous work suggested attenuation of associated risk in older adults, who have highest risk of both CHIP + CVD
August 27, 2025 at 2:36 PM
(2/X)
CHIP = aging-related acquired blood stem cell mutations that predispose to blood cancers
We + others have shown that CHIP also associates w/ ⬆️ CVD risk
But previous work suggested attenuation of associated risk in older adults, who have highest risk of both CHIP + CVD
CHIP = aging-related acquired blood stem cell mutations that predispose to blood cancers
We + others have shown that CHIP also associates w/ ⬆️ CVD risk
But previous work suggested attenuation of associated risk in older adults, who have highest risk of both CHIP + CVD
The lab's first sim pub of #ESC2025 is now online in
@jaccjournals.bsky.social #JACC!
jacc.org/doi/10.1016/...
Led by 🇧🇪⭐️ @danielezzat.bsky.social , we examined clonal hematopoiesis (CHIP) 🩸 & CV 🫀 outcomes in older women 👵 using deep targeted 🧬 sequencing in the WHI Long Life Study
👇
(1/X)
@jaccjournals.bsky.social #JACC!
jacc.org/doi/10.1016/...
Led by 🇧🇪⭐️ @danielezzat.bsky.social , we examined clonal hematopoiesis (CHIP) 🩸 & CV 🫀 outcomes in older women 👵 using deep targeted 🧬 sequencing in the WHI Long Life Study
👇
(1/X)
August 27, 2025 at 2:35 PM
The lab's first sim pub of #ESC2025 is now online in
@jaccjournals.bsky.social #JACC!
jacc.org/doi/10.1016/...
Led by 🇧🇪⭐️ @danielezzat.bsky.social , we examined clonal hematopoiesis (CHIP) 🩸 & CV 🫀 outcomes in older women 👵 using deep targeted 🧬 sequencing in the WHI Long Life Study
👇
(1/X)
@jaccjournals.bsky.social #JACC!
jacc.org/doi/10.1016/...
Led by 🇧🇪⭐️ @danielezzat.bsky.social , we examined clonal hematopoiesis (CHIP) 🩸 & CV 🫀 outcomes in older women 👵 using deep targeted 🧬 sequencing in the WHI Long Life Study
👇
(1/X)
Fantastic joint lab retreat today w/ @pnatarajanmd.bsky.social @zhiyu.bsky.social & Akl Fahed labs
Honigberg lab is rapidly growing 📈 👇
@mghcvrc.bsky.social @mgbwomenheart.bsky.social @mgbresearch.bsky.social
Honigberg lab is rapidly growing 📈 👇
@mghcvrc.bsky.social @mgbwomenheart.bsky.social @mgbresearch.bsky.social
August 21, 2025 at 10:10 PM
Fantastic joint lab retreat today w/ @pnatarajanmd.bsky.social @zhiyu.bsky.social & Akl Fahed labs
Honigberg lab is rapidly growing 📈 👇
@mghcvrc.bsky.social @mgbwomenheart.bsky.social @mgbresearch.bsky.social
Honigberg lab is rapidly growing 📈 👇
@mghcvrc.bsky.social @mgbwomenheart.bsky.social @mgbresearch.bsky.social
The latest from our @americanheart.bsky.social -funded BUSY-BP study, led by MGH medicine resident Lulu Belak, now in Obstet Gynecol @greenjrnl.bsky.social
In Black + Latina 👭, burden of health-related social needs in pregnancy was associated w/ adverse 🤰 outcomes
journals.lww.com/greenjournal...
In Black + Latina 👭, burden of health-related social needs in pregnancy was associated w/ adverse 🤰 outcomes
journals.lww.com/greenjournal...
July 3, 2025 at 9:42 PM
The latest from our @americanheart.bsky.social -funded BUSY-BP study, led by MGH medicine resident Lulu Belak, now in Obstet Gynecol @greenjrnl.bsky.social
In Black + Latina 👭, burden of health-related social needs in pregnancy was associated w/ adverse 🤰 outcomes
journals.lww.com/greenjournal...
In Black + Latina 👭, burden of health-related social needs in pregnancy was associated w/ adverse 🤰 outcomes
journals.lww.com/greenjournal...
Huge congrats to @massgeneralbrigham.bsky.social MGH medicine resident Amanda Jowell for receiving a top resident abstract award for her analysis of female-specific CVD risk factors in severe hypercholesterolemia 🏆 @mgbwomenheart.bsky.social @mghcvrc.bsky.social
May 29, 2025 at 2:10 PM
Huge congrats to @massgeneralbrigham.bsky.social MGH medicine resident Amanda Jowell for receiving a top resident abstract award for her analysis of female-specific CVD risk factors in severe hypercholesterolemia 🏆 @mgbwomenheart.bsky.social @mghcvrc.bsky.social
Big congrats to Maria Pabon for winning the inaugural @mgbwomenheart.bsky.social / @ishvnews.bsky.social Young Investigators' Award (basic/translational category) for her work on endothelial cell transcriptomics in preeclampsia (www.ahajournals.org/doi/10.1161/...)! 🏆 @cardioob.bsky.social
May 10, 2025 at 5:38 PM
Big congrats to Maria Pabon for winning the inaugural @mgbwomenheart.bsky.social / @ishvnews.bsky.social Young Investigators' Award (basic/translational category) for her work on endothelial cell transcriptomics in preeclampsia (www.ahajournals.org/doi/10.1161/...)! 🏆 @cardioob.bsky.social
Our latest on 🫀 health, 🧬, and 🤰 now out in @jaccjournals.bsky.social #JACC
First-trimester cardiovascular health strongly associates with development of hypertensive disorders of 🤰 (HDP)
overall and across levels of HDP genetic risk
www.jacc.org/doi/10.1016/...
#CardioObstetrics #CardioSky
First-trimester cardiovascular health strongly associates with development of hypertensive disorders of 🤰 (HDP)
overall and across levels of HDP genetic risk
www.jacc.org/doi/10.1016/...
#CardioObstetrics #CardioSky
April 8, 2025 at 1:43 AM
Our latest on 🫀 health, 🧬, and 🤰 now out in @jaccjournals.bsky.social #JACC
First-trimester cardiovascular health strongly associates with development of hypertensive disorders of 🤰 (HDP)
overall and across levels of HDP genetic risk
www.jacc.org/doi/10.1016/...
#CardioObstetrics #CardioSky
First-trimester cardiovascular health strongly associates with development of hypertensive disorders of 🤰 (HDP)
overall and across levels of HDP genetic risk
www.jacc.org/doi/10.1016/...
#CardioObstetrics #CardioSky
Great in-depth review in this year's @ahajournals.bsky.social #Circulation Go Red for Women 💃 issue on HTN during & after 🤰 from the @accintouch.bsky.social CVD in Women Committee & Cardio-OB/Repro Health Section led by Malamo Countouris and Zainab Mahmoud
👇
www.ahajournals.org/doi/full/10....
👇
www.ahajournals.org/doi/full/10....
February 17, 2025 at 10:41 PM
Great in-depth review in this year's @ahajournals.bsky.social #Circulation Go Red for Women 💃 issue on HTN during & after 🤰 from the @accintouch.bsky.social CVD in Women Committee & Cardio-OB/Repro Health Section led by Malamo Countouris and Zainab Mahmoud
👇
www.ahajournals.org/doi/full/10....
👇
www.ahajournals.org/doi/full/10....
In our latest led by Maria Pabon (MGB/BWH) now in Circ Res, we sequenced RNA from venous endothelial cells from 🤰 w/ or w/o preeclampsia
We 👀 evidence that an aminopeptidase, METAP1, drives EC dysfunction in preeclampsia
www.ahajournals.org/doi/10.1161/...
#CardioObstetrics @mghcvrc.bsky.social
We 👀 evidence that an aminopeptidase, METAP1, drives EC dysfunction in preeclampsia
www.ahajournals.org/doi/10.1161/...
#CardioObstetrics @mghcvrc.bsky.social
December 27, 2024 at 11:57 AM
In our latest led by Maria Pabon (MGB/BWH) now in Circ Res, we sequenced RNA from venous endothelial cells from 🤰 w/ or w/o preeclampsia
We 👀 evidence that an aminopeptidase, METAP1, drives EC dysfunction in preeclampsia
www.ahajournals.org/doi/10.1161/...
#CardioObstetrics @mghcvrc.bsky.social
We 👀 evidence that an aminopeptidase, METAP1, drives EC dysfunction in preeclampsia
www.ahajournals.org/doi/10.1161/...
#CardioObstetrics @mghcvrc.bsky.social
Terrific holiday party / “Yankee swap” 🎁🔄🎁 with @mchonig.bsky.social @zhiyu.bsky.social Fahed + @pnatarajanmd.bsky.social labs 🎅 🎄 @massgeneralbrigham.bsky.social MGB Heart + @broadinstitute.org @broadinstitute.bsky.social
December 19, 2024 at 12:37 AM
Terrific holiday party / “Yankee swap” 🎁🔄🎁 with @mchonig.bsky.social @zhiyu.bsky.social Fahed + @pnatarajanmd.bsky.social labs 🎅 🎄 @massgeneralbrigham.bsky.social MGB Heart + @broadinstitute.org @broadinstitute.bsky.social
So so incredibly proud of 🇧🇪’s finest @artschuermans.bsky.social for this incredibly well-deserved recognition as the @ukbiobank.bsky.social Early Career Researcher of the Year for 2024! ⭐️ Lots of high-impact work so quickly - and lots more to come
CC @broadinstitute.org @pnatarajanmd.bsky.social
CC @broadinstitute.org @pnatarajanmd.bsky.social
December 10, 2024 at 4:39 PM
So so incredibly proud of 🇧🇪’s finest @artschuermans.bsky.social for this incredibly well-deserved recognition as the @ukbiobank.bsky.social Early Career Researcher of the Year for 2024! ⭐️ Lots of high-impact work so quickly - and lots more to come
CC @broadinstitute.org @pnatarajanmd.bsky.social
CC @broadinstitute.org @pnatarajanmd.bsky.social
Maria Pabon of BWH cardiology presenting her work on biomarkers in 🤰 and postpartum cardiometabolic trajectories at #AHA24 #cardioobstetrics #cardiosky #medsky
November 18, 2024 at 7:52 PM
Maria Pabon of BWH cardiology presenting her work on biomarkers in 🤰 and postpartum cardiometabolic trajectories at #AHA24 #cardioobstetrics #cardiosky #medsky
Fantastic thought provoking cardiometabolic and 🫀 prevention research at this morning’s featured oral abstract session #AHA24 @ahascience.bsky.social #CardioSky #MedSky
November 17, 2024 at 4:13 PM
Fantastic thought provoking cardiometabolic and 🫀 prevention research at this morning’s featured oral abstract session #AHA24 @ahascience.bsky.social #CardioSky #MedSky
Great YIA presentation by ⭐️ Kelvin Supriami at #AHA24 of our data integrating @MGHHeartHealth cor angio data + Lp(a)
Very ⬆️ Lp(a) (>=175 nmol/L) associated w/ repeat angiography, ISR, revasc, & mortality after cath, + need for PCI after CABG, indept of baseline athero burden
#CardioSky #MedSky
Very ⬆️ Lp(a) (>=175 nmol/L) associated w/ repeat angiography, ISR, revasc, & mortality after cath, + need for PCI after CABG, indept of baseline athero burden
#CardioSky #MedSky
November 16, 2024 at 4:57 PM
Great YIA presentation by ⭐️ Kelvin Supriami at #AHA24 of our data integrating @MGHHeartHealth cor angio data + Lp(a)
Very ⬆️ Lp(a) (>=175 nmol/L) associated w/ repeat angiography, ISR, revasc, & mortality after cath, + need for PCI after CABG, indept of baseline athero burden
#CardioSky #MedSky
Very ⬆️ Lp(a) (>=175 nmol/L) associated w/ repeat angiography, ISR, revasc, & mortality after cath, + need for PCI after CABG, indept of baseline athero burden
#CardioSky #MedSky
SUMMIT @ #AHA24
N=731 w/ obesity + HFpEF (EF >=50%) + enrichment factors randomized to tirzepatide vs placebo, >50% 🙋♀️!, most w/ low BNP, med f/u 104 wks
Co-PEP: (1) worsening HF or CV 💀 (2) KCCQ
Tirzepatide ➡️ HR 0.62 for worsening HF/CV 💀, driven by worsening HF
www.nejm.org/doi/full/10....
N=731 w/ obesity + HFpEF (EF >=50%) + enrichment factors randomized to tirzepatide vs placebo, >50% 🙋♀️!, most w/ low BNP, med f/u 104 wks
Co-PEP: (1) worsening HF or CV 💀 (2) KCCQ
Tirzepatide ➡️ HR 0.62 for worsening HF/CV 💀, driven by worsening HF
www.nejm.org/doi/full/10....
November 16, 2024 at 3:26 PM
SUMMIT @ #AHA24
N=731 w/ obesity + HFpEF (EF >=50%) + enrichment factors randomized to tirzepatide vs placebo, >50% 🙋♀️!, most w/ low BNP, med f/u 104 wks
Co-PEP: (1) worsening HF or CV 💀 (2) KCCQ
Tirzepatide ➡️ HR 0.62 for worsening HF/CV 💀, driven by worsening HF
www.nejm.org/doi/full/10....
N=731 w/ obesity + HFpEF (EF >=50%) + enrichment factors randomized to tirzepatide vs placebo, >50% 🙋♀️!, most w/ low BNP, med f/u 104 wks
Co-PEP: (1) worsening HF or CV 💀 (2) KCCQ
Tirzepatide ➡️ HR 0.62 for worsening HF/CV 💀, driven by worsening HF
www.nejm.org/doi/full/10....
BPROAD at #AHA24 sim pub in NEJM
N=12,821 Chinese adults >=50 y with T2D randomized to 🎯 SBP <140 vs <120 mmHg, 45% 🙋♀️, median 4.2 y f/u
PEP: composite MI, CVA, HF, CV death
Intensive BP control ➡️ HR 0.79 (95%CI 0.69-0.90)
Results differ from those of ACCORD (2010)
www.nejm.org/doi/full/10....
N=12,821 Chinese adults >=50 y with T2D randomized to 🎯 SBP <140 vs <120 mmHg, 45% 🙋♀️, median 4.2 y f/u
PEP: composite MI, CVA, HF, CV death
Intensive BP control ➡️ HR 0.79 (95%CI 0.69-0.90)
Results differ from those of ACCORD (2010)
www.nejm.org/doi/full/10....
November 16, 2024 at 3:00 PM
BPROAD at #AHA24 sim pub in NEJM
N=12,821 Chinese adults >=50 y with T2D randomized to 🎯 SBP <140 vs <120 mmHg, 45% 🙋♀️, median 4.2 y f/u
PEP: composite MI, CVA, HF, CV death
Intensive BP control ➡️ HR 0.79 (95%CI 0.69-0.90)
Results differ from those of ACCORD (2010)
www.nejm.org/doi/full/10....
N=12,821 Chinese adults >=50 y with T2D randomized to 🎯 SBP <140 vs <120 mmHg, 45% 🙋♀️, median 4.2 y f/u
PEP: composite MI, CVA, HF, CV death
Intensive BP control ➡️ HR 0.79 (95%CI 0.69-0.90)
Results differ from those of ACCORD (2010)
www.nejm.org/doi/full/10....
Gestational 🤰 diabetes is associated w/ long-term 🫀 disease risk, but is GDM *causal* for CVD?
A new analysis using 🧬 suggests the answer is no - rather, GDM & CVD likely share upstream risk pathways. #cardiosky
Our editorial led by Maddy Ardissino now in the EHJ: academic.oup.com/eurheartj/ad...
A new analysis using 🧬 suggests the answer is no - rather, GDM & CVD likely share upstream risk pathways. #cardiosky
Our editorial led by Maddy Ardissino now in the EHJ: academic.oup.com/eurheartj/ad...
November 12, 2024 at 12:56 AM
Gestational 🤰 diabetes is associated w/ long-term 🫀 disease risk, but is GDM *causal* for CVD?
A new analysis using 🧬 suggests the answer is no - rather, GDM & CVD likely share upstream risk pathways. #cardiosky
Our editorial led by Maddy Ardissino now in the EHJ: academic.oup.com/eurheartj/ad...
A new analysis using 🧬 suggests the answer is no - rather, GDM & CVD likely share upstream risk pathways. #cardiosky
Our editorial led by Maddy Ardissino now in the EHJ: academic.oup.com/eurheartj/ad...