Kaitlin McCreery
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mccreery.bsky.social
Kaitlin McCreery
@mccreery.bsky.social
We study the cell nucleus and the tissue microenvironment, driving dynamic cell mechanics. Multiscale Bioengineering Lab at College of Engineering & Mathematical Sciences at the University of Vermont. mccreerylab.com
Reposted by Kaitlin McCreery
Appreciate Quanta for shining a light on our joint work with Simon Gsell, Sham Tlili (@shamtlili.bsky.social), and Matthias Merkel (@merkellab.bsky.social).
October 11, 2025 at 7:04 AM
Reposted by Kaitlin McCreery
💫NEW: @sarawickstrom.bsky.social @katemiro.bsky.social & co show that mechano-osmotic changes in the #nucleus induce general #transcriptional repression and prime #chromatin for cell fate transitions by relieving repression of specific differentiation genes. #pluripotency
bit.ly/3VMcyNZ
Mechano-osmotic signals control chromatin state and fate transitions in pluripotent stem cells - Nature Cell Biology
McCreery, Stubb et al. show that mechano-osmotic changes in the nucleus induce general transcriptional repression and prime chromatin for cell fate transitions by relieving repression of specific differentiation genes.
bit.ly
October 4, 2025 at 2:40 PM
Reposted by Kaitlin McCreery
See this? This = implanting mouse embryo. Usually this happens inside its mother and is invisible to us, but we can actually watch implantation ex vivo with the hope of understanding why implantation goes awry in embryos of older women. A 🧵...
October 1, 2025 at 6:21 PM
Reposted by Kaitlin McCreery
Amazing to have our work finally out!!! 😍🤩😍
September 29, 2025 at 6:38 PM
Reposted by Kaitlin McCreery
Mechano-osmotic signals control chromatin state and fate transitions in pluripotent stem cells @natcellbio.nature.com @sarawickstrom.bsky.social @akistubb.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
September 29, 2025 at 8:28 PM
Our paper is out in Nature Cell Biology! 🚀 Growth factors, mechanical forces, and osmotic stress work together to guide stem cell differentiation. Delighted to see these discoveries out in the world 🔥
September 29, 2025 at 10:27 PM
Reposted by Kaitlin McCreery
How do LMNA mutations cause dilated cardiomyopathy (DCM) and other #laminopathies? In our latest preprint (doi.org/10.1101/2024...), led by the amazing Noam Zuela-Sopilniak and Julien Morival, we show that cardiomyocyte-specific lamin A/C depletion causes severe DCM, consistent with other studies.
September 18, 2025 at 6:12 PM
Reposted by Kaitlin McCreery
Another paper bluetorial! Today: how does the spatial location of genes influence their function? (1/n) www.nature.com/articles/s41...
The nuclear periphery confers repression on H3K9me2-marked genes and transposons to shape cell fate - Nature Cell Biology
Marin et al. report the role of lamin proteins and the lamin B receptor (LBR) in chromatin positioning at the nuclear periphery. Knockout of all lamins and LBR in mouse embryonic stem cells leads to h...
www.nature.com
July 22, 2025 at 5:10 PM
Reposted by Kaitlin McCreery
How do altered levels of lamins and other nuclear envelope proteins contribute to cancer metastasis, and what role does #mechanobiology play here? Learn more in our recent review by fantastic Sarah Henretta, now out in NPJ - Biological Physics and Mechanics, open access: doi.org/10.1038/s443...
Nuclear envelope proteins, mechanotransduction, and their contribution to breast cancer progression - npj Biological Physics and Mechanics
npj Biological Physics and Mechanics - Nuclear envelope proteins, mechanotransduction, and their contribution to breast cancer progression
doi.org
May 12, 2025 at 7:25 AM
Reposted by Kaitlin McCreery
Cool new method to integrate mechanics and transcriptomics, can’t wait to try it out 🤓 Congratulations Adrien @halloulab.bsky.social & team!
March 18, 2025 at 7:12 AM
Our review "Measuring and manipulating mechanical forces during development" is now published in Nature Cell Biology!

#Mechanobiology #DevelopmentalBiology
March 12, 2025 at 12:39 PM
Reposted by Kaitlin McCreery
UVM is now a Carnegie R1 institution! This achievement reflects decades of dedication to cutting-edge research, innovation, and excellence. With over $260M in funding (FY24) and groundbreaking projects, we're on the course for an even more ambitious future! #UVMresearch
UVM Achieves Prestigious Carnegie R1 Designation, Joining Highest Level of U.S. Research Institutions | Office of the Vice President for Research (OVPR) | The University of Vermont
www.uvm.edu
February 13, 2025 at 4:32 PM