Thanks! I think it’s just edge detection & 3D project plus a little B&C adjustment in FIJI 🙂

I agree, lately I increasingly prefer to frame gaps in knowledge as questions rather than these types of “little is known/poorly understood” statements, which are inherently vague and subjective. Questions are more engaging to a reader too imo

Thanks Andrew! Yes that’s exactly the type of analysis I’m working on, defining “organization” in a way that can be compared between different cell types (I.e a specific set of morph metrics) is gonna be crucial

🙌

Many thanks to my co-author Brooke Weingard, my advisors Steve Goodman & @wallaceucsf.bsky.social , my Marshall lab mates and many others who have been supportive of this sort of oddball project. Now more than ever, I'm humbled by the absolute privilege of doing science! thanks for reading!
11/11

I'm excited for this chance to highlight the power of rigorous evidence synthesis for fundamental cell biology, something I hope to see more of and help develop in the future! If you're interested in the intersection of evidence/knowledge synthesis & fundamental bio please connect with me!
10/11

Stay tuned for part two of this story which will dive into the linguistic and conceptual basis of "cell anatomy" throughout the corpus. We plan on keeping this corpus up to date & expanding its scope as a collaborative interactive resource (we call it a "living corpus" as a running joke )
9/11

We believe that the acceleration of whole-cell imaging tech & data in recent years represents the early stages of an emerging field. Hopefully this work will serve as a useful tool and catalyst for community discourse to standardize technical & conceptual norms.
8/11

But there are biases in the dataset! Namely small sample sizes, small cell types, non-mammalian cell types. This is a reflection of how technically challenging and costly whole-cell data is, even further highlighting the value of pooling datasets for research synthesis work.
7/11