Adrien Lemaignen
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lemaignen.bsky.social
Adrien Lemaignen
@lemaignen.bsky.social
470 followers 58 following 16 posts
ID doc - specific interest in epidemiology, bone and joint infections, bloodstream infections and endocarditis, zoonoses
Tours, France
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lemaignen.bsky.social
Thanks!
December 8, 2025 at 8:22 PM
Reposted by Adrien Lemaignen
ofidjournal.bsky.social
Triazoles versus Echinocandins for the first-line treatment of invasive pulmonary aspergillosis ? A propensity score weighted multicenter study

✅ Just Accepted
🔗 https://bit.ly/3LV7LYP
December 7, 2025 at 10:53 PM
Reposted by Adrien Lemaignen
infdiseasesnow.bsky.social
[Publication] The article "Characteristics of tuberculosis in elderly adults: A multicenter French study" is now available.

www.sciencedirect.com/science/arti...

#IDsky #Tuberculosis #ElderlyAdults #AtypicalPresentation #GeriatricInfectiousDisease #Mortality
Characteristics of tuberculosis in elderly adults: A multicenter French study
The incidence of tuberculosis (TB) remains high in elderly adults in France. Immunosenescence and comorbidities challenge both diagnosis and treatment…
www.sciencedirect.com
December 8, 2025 at 8:02 AM
Reposted by Adrien Lemaignen
infdiseasesnow.bsky.social
[Publication] The article "Seasonal influenza and pneumococcal vaccination coverage among immunocompromised adults in France: A need for improvement" is now available.

www.sciencedirect.com/science/arti...

#IDsky #Immunocompromised #Vaccines #StreptococcusPneumoniae #Influenza #France
Seasonal influenza and pneumococcal vaccination coverage among immunocompromised adults in France: A need for improvement
To estimate influenza and pneumococcal vaccination coverage in immunocompromised adults in France.We used the Echantillon Généraliste des Bénéficiaire…
www.sciencedirect.com
December 8, 2025 at 8:03 AM
Reposted by Adrien Lemaignen
nejm.org
In the SONIA trial conducted in general medical wards with limited diagnostic and therapeutic resources in Kenya, glucocorticoids reduced mortality in patients with community-acquired pneumonia. Full trial results and Research Summary: nej.md/47glh02

#MedSky #PulmSky #IDSky
The New England Journal of Medicine A Pragmatic Trial of Glucocorticoids for Community-Acquired Pneumonia A Research Summary based on Lucinde RK et al. | 10.1056/NEJMoa2507100 | Published on October 29, 2025 Visual representations of the patients in the trial and the treatments they were assigned. Read the full Research Summary at NEJM.org.
December 8, 2025 at 2:34 PM
Reposted by Adrien Lemaignen
ofidjournal.bsky.social
Diagnostic Efficacy and Clinical Impact of Image-guided Core Needle Biopsy of Suspected Adult Non-Vertebral Osteomyelitis

✅ Just Accepted
🔗 https://bit.ly/4oYHCGS
November 5, 2025 at 7:40 PM
Reposted by Adrien Lemaignen
absteward.bsky.social
🆕🌟Excellent review article
P2Y12 inhibitors(eg clopidogrel,ticagrelor)in Staphylococcus aureus bacteraemia: current evidence and clinical implications
Coming soon: CLOPI-SNAP+ Clopido-SNAP #idsky #EMIMCC
www.thelancet.com/journals/lan...
P2Y12 inhibitors in Staphylococcus aureus bacteraemia: current evidence and clinical implications
Staphylococcus aureus bacteraemia presents a substantial clinical burden, with high rates of morbidity and mortality. Despite its severity, therapeutic advancements have been small in the past decade,...
www.thelancet.com
October 31, 2025 at 8:18 PM
Reposted by Adrien Lemaignen
cidjournal.bsky.social
Effectiveness of Nebulized Bronchodilator - Enhanced Sputum Induction in Thai Patients with Presumed Pulmonary Tuberculosis; A Randomized Controlled Trial; (NeB-TB Trial)

✅ Just Accepted
#IDSky
Effectiveness of Nebulized Bronchodilator - Enhanced Sputum Induction in Thai Patients with Presumed Pulmonary Tuberculosis; A Randomized Controlled Trial; (NeB-TB Trial)
AbstractBackground. Delayed pulmonary tuberculosis (TB) diagnosis, especially with limited bronchoscopy resources, worsens outcomes and increases transmiss
bit.ly
October 28, 2025 at 3:51 PM
Reposted by Adrien Lemaignen
infdiseasesnow.bsky.social
[Publication] The article "Risk factors for deep vein thrombosis during peripherally inserted central catheter-related infections: A retrospective study" is now available.

www.sciencedirect.com/science/arti...

#IDsky #PeripherallyInsertedCentralCatheter #DeepVeinThrombosis #RiskFactors #S.Aureus
Risk factors for deep vein thrombosis during peripherally inserted central catheter-related infections: A retrospective study
Peripherally inserted central catheters (PICCs) are associated with complications including deep vein thrombosis (DVT) and infections. However, the ri…
www.sciencedirect.com
October 27, 2025 at 7:12 AM
Reposted by Adrien Lemaignen
cellpress.bsky.social
DNA from Napoleon’s 1812 army identifies the pathogens likely responsible for the army’s demise during their Russian retreat. www.cell.com/current-biol...

Nicolás Rascovan & colleagues
@currentbiology.bsky.social
Napoleon's retreat from Moscow CREDIT Barbieri et al., Current Biology
October 24, 2025 at 3:00 PM
Reposted by Adrien Lemaignen
jidjournal.bsky.social
Syphilis Pathogenesis: Host Immune Response vs Pathogen Immune Evasion

#IDSky
Syphilis Pathogenesis: Host Immune Response vs Pathogen Immune Evasion
Syphilis, caused by Treponema pallidum subspecies pallidum, remains a significant global health problem despite being preventable and curable.
bit.ly
October 26, 2025 at 7:44 PM
Reposted by Adrien Lemaignen
jac-amr.bsky.social
This monocentric observational study of 137 patients with bone & joint infection treated by clindamycin of which 88 received monotherapy shows in univariate, multivariate & IPTW analysis a reliable & safe use of monotherapy in those infections:
doi.org/10.1093/jaca...
#JACAMRNews #IDSky
doi.org
October 23, 2025 at 10:03 AM
Reposted by Adrien Lemaignen
absteward.bsky.social
🆕🔥🔥CloCeBa RCT
Cloxacillin versus cefazolin for MSSA Bacteraemia
Cefazolin has a non-inferior efficacy regarding mortality, microbiological or clinical endpoints and was associated with a lower rate of serious adverse events #IDSky
www.thelancet.com/journals/lan...
October 19, 2025 at 4:34 AM
Reposted by Adrien Lemaignen
lancetmicrobe.bsky.social
New review article

Role of gut #microbiota disruption in prosthetic joint infection: a scoping review

www.thelancet.com/journals/lan...

#IDSky #ClinMicro #PJI #OpenAccess #OA
September 8, 2025 at 2:09 PM
Reposted by Adrien Lemaignen
absteward.bsky.social
🆕🔥State of art review with many🌟s
+ Prof. Jason Roberts
Antibiotic therapy for severe bacterial infections
🟢When to start and not to start antibiotics?
🟢Mon vs combo Abx
🟢PK/PD principles
🟢Drug–drug inx
A #mustread article for ID professional #idsky
link.springer.com/article/10.1...
September 2, 2025 at 2:03 PM
Reposted by Adrien Lemaignen
absteward.bsky.social
Rapid diagnostic tests combined with individualised decision-making improve the selection of antibiotic therapy. Rapid de-escalation to narrow-spectrum monotherapy and shortening of the duration of therapy should be the rule. #IDsky #EMIMCC
absteward.bsky.social Antibiotic Steward 🅱️C🆔🅿️🌟 @absteward.bsky.social · Sep 2
🆕🔥State of art review with many🌟s
+ Prof. Jason Roberts
Antibiotic therapy for severe bacterial infections
🟢When to start and not to start antibiotics?
🟢Mon vs combo Abx
🟢PK/PD principles
🟢Drug–drug inx
A #mustread article for ID professional #idsky
link.springer.com/article/10.1...
September 2, 2025 at 8:26 PM
Reposted by Adrien Lemaignen
idsainfo.bsky.social
In CID, Maria Ines Figueroa and colleagues evaluated the antiviral activity of dolutegravir/lamivudine among antiretroviral therapy (ART)-naive patients with HIV with a CD4 count ≤200 cells/mm³. https://academic.oup.com/cid/advance-article/doi/10.1093/cid/ciaf415/8241230
Efficacy and Safety of Dual Therapy With Dolutegravir/Lamivudine in Treatment-naive Persons With CD4 Counts <200/mm3: 48-Week Results of the DOLCE Study
Treatment-naive people with human immunodeficiency virus with very low CD4 counts and high viral load are a difficult-to-treat population. DOLCE explored t
academic.oup.com
September 3, 2025 at 2:20 AM
Reposted by Adrien Lemaignen
drtimothyli.bsky.social
This retrospective cohort from 🇫🇷showed that oral switch is a suitable option for treating IE, even for POET-ineligible patients

➡️treatment failure HR=0.55 favoring oral, 95%CI 0.27-1.17
➡️more days alive outside 🏥 in oral group (59 vs 47, p=0.001)

doi.org/10.1093/cid/...

#IDSky
August 18, 2025 at 2:48 PM
Reposted by Adrien Lemaignen
infdiseasesnow.bsky.social
[Publication] The article "West Nile virus in Italy: A rising public health concern calling for reinforced surveillance and preventive measures" is now available.

www.sciencedirect.com/science/arti...

#IDsky #WestNileVirus #PublicHealthSurveillance #VectorBorneDiseases #OneHealthApproachItaly
West Nile virus in Italy: A rising public health concern calling for reinforced surveillance and preventive measures
www.sciencedirect.com
August 8, 2025 at 7:56 AM
Reposted by Adrien Lemaignen
ofidjournal.bsky.social
The Use of Oritavancin as Consolidation Therapy for Infective Endocarditis Caused by Enterococcus spp.

✅ Just Accepted
#IDSky
The Use of Oritavancin as Consolidation Therapy for Infective Endocarditis Caused by Enterococcus spp.
Oritavancin is emerging as a potential alternative to standard antibiotic regimens in the treatment of infective endocarditis caused by gram-positive bacteria, though evidence remains limited.
doi.org
August 5, 2025 at 2:49 PM
Reposted by Adrien Lemaignen
cidjournal.bsky.social
State-of-the-Art Review: Anal Cancer Screening in People With HIV

#IDSky
academic.oup.com/cid/article/...
State-of-the-Art Review: Anal Cancer Screening in People With HIV
New data and clinical guidelines support anal cancer screening of people with HIV, but important questions related to overall effectiveness, harms, and equitable deployment must be considered when implementing them.
academic.oup.com
August 4, 2025 at 6:58 PM
Reposted by Adrien Lemaignen
cidjournal.bsky.social
Adjunctive Fosfomycin for the Treatment of Staphylococcus aureus Bacteremia: A Pooled Post-hoc Analysis of Individual Participant Data from Two Randomized Trials

✅ Just Accepted
#IDSky
Adjunctive Fosfomycin for the Treatment of Staphylococcus aureus Bacteremia: A Pooled Post-hoc Analysis of Individual Participant Data from Two Randomized Trials
The role of adjunctive fosfomycin in Staphylococcus aureus bacteremia (SAB) remains uncertain.
doi.org
July 17, 2025 at 6:58 PM
Reposted by Adrien Lemaignen
cidjournal.bsky.social
Metagenomic Next-Generation Sequencing of Cerebrospinal Fluid: First Year Experience at a Tertiary Referral Hospital

✅ Just Accepted
#IDSky
Metagenomic Next-Generation Sequencing of Cerebrospinal Fluid: First Year Experience at a Tertiary Referral Hospital
Central nervous system (CNS) infections are significant causes of morbidity and mortality, especially when diagnosis is delayed.
doi.org
July 18, 2025 at 12:41 PM
Reposted by Adrien Lemaignen
sebpoule.bsky.social
SNAP trial update

➡️ The DSMC provided a recommendation to close the ADJUNCTIVE domain (Clindamycin), due to a statistical trigger for futility being met.

#IDsky
July 16, 2025 at 11:07 AM
Reposted by Adrien Lemaignen
germhuntermd.bsky.social
2025 Clinical Practice Guideline Update by the Infectious Diseases Society of America on Histoplasmosis: Treatment of Asymptomatic Histoplasma Pulmonary Nodules (Histoplasmomas) in Adults, Children, and Pregnant People

@jobadd.bsky.social @joshuawolf.bsky.social et al

doi.org/10.1093/cid/...
Screenshot of title and authors for 2025 Clinical Practice Guideline Update by the Infectious Diseases Society of America on Histoplasmosis: Treatment of Asymptomatic Histoplasma Pulmonary Nodules (Histoplasmomas) in Adults, Children, and Pregnant People
July 8, 2025 at 2:34 PM