Luisa Cochella
@lcochella.bsky.social
Proud worm researcher. Interested in miRNAs, all RNAs really, and gene regulation in general. A biochemist turned geneticist trying to think about questions of cell biology. Lucky to lead a lab at Johns Hopkins School of medicine. https://cochellalab.org/
Thanks Eric!
Made possible by CRISPR technology, Emilio's expert design and injection skills, and loads of Cas9 purified and gifted to us by Geraldine Seydoux's lab... and a pinch of craziness : )
Made possible by CRISPR technology, Emilio's expert design and injection skills, and loads of Cas9 purified and gifted to us by Geraldine Seydoux's lab... and a pinch of craziness : )
September 4, 2025 at 1:46 AM
Thanks Eric!
Made possible by CRISPR technology, Emilio's expert design and injection skills, and loads of Cas9 purified and gifted to us by Geraldine Seydoux's lab... and a pinch of craziness : )
Made possible by CRISPR technology, Emilio's expert design and injection skills, and loads of Cas9 purified and gifted to us by Geraldine Seydoux's lab... and a pinch of craziness : )
Thanks, Andi : )
September 3, 2025 at 11:20 PM
Thanks, Andi : )
We loved working with you Ralf! We gave you a little shoutout in the acknowledgements, but we always remember that you were the one who noticed the kal-1 reporter under the microscope : )
September 3, 2025 at 7:54 PM
We loved working with you Ralf! We gave you a little shoutout in the acknowledgements, but we always remember that you were the one who noticed the kal-1 reporter under the microscope : )
Lots more to dig into in the paper : )
Congrats Emilio and everyone involved!!!
Congrats Emilio and everyone involved!!!
September 3, 2025 at 6:16 PM
Lots more to dig into in the paper : )
Congrats Emilio and everyone involved!!!
Congrats Emilio and everyone involved!!!
In a tour de force experiment, Emilio made a worm strain with 13 variant 3'UTRs, mutating the miR-51/miR-100 binding sites in high confidence targets. This phenocopies some of the defects observed upon loss of the miRNA, providing causality between modest derepression of many targets and phenotype!
September 3, 2025 at 6:16 PM
In a tour de force experiment, Emilio made a worm strain with 13 variant 3'UTRs, mutating the miR-51/miR-100 binding sites in high confidence targets. This phenocopies some of the defects observed upon loss of the miRNA, providing causality between modest derepression of many targets and phenotype!
Amazing! And the jokers are 🔥😂
August 28, 2025 at 5:07 PM
Amazing! And the jokers are 🔥😂