koolchemistry.bsky.social
@koolchemistry.bsky.social
Excited that our paper on RiboLight (RL) dyes has been published - multicolor reactive dyes that are RNA-specific. They work great in gels and in live cells
pubs.acs.org/doi/10.1021/jacs.5c14938
November 21, 2025 at 3:35 PM
We all know that DNA damage in our cells is dangerous - but how about in our food? Postdoc Jinwoo Shin's study shows that DNA in some foods is highly damaged by cooking and that it may be hazardous to us -
pubs.acs.org/doi/10.1021/acs.jafc.5c08138
November 3, 2025 at 4:31 PM
Our study of pseudouridines in RNA was just published - it turns out that they stabilize RNA from cleavage by having much less nucleophilic 2'-OH groups:
pubs.acs.org/doi/10.1021/acscentsci.5c01345
October 28, 2025 at 2:24 PM
Spoke at Monday's ACS symposium in honor of Peter Dervan's birthday - it was a great time seeing Peter, Jackie, and the many alums who he trained
March 26, 2025 at 7:46 PM
Congratulations to Yixuan (Edward) Gao for publication of his paper on the first SMUG1 small molecule activator - it upregulates pyrimidine repair in cellular models. doi.org/10.1016/j.dnarep.2025.103809
February 2, 2025 at 6:28 PM
...and then I told it to give it the correct twist - not a particularly good result
December 24, 2024 at 5:39 PM
so I asked ChatGPT to make a cartoon of DNA - and it made it left handed...
December 24, 2024 at 5:38 PM
this one looks AI generated
-not a helix, but looks helix-y
December 19, 2024 at 6:52 PM
Congrats to Edward Gao on the publication of his paper - an improved synthesis of damaged pyrimidines -

doi: 10.1080/15257770.2024.2437038
December 19, 2024 at 6:36 PM
when a helix is not a helix
November 27, 2024 at 4:36 PM
DNA Publicity Art of the Day:

✘ left-hand twist
✅ dryer hose construction
November 26, 2024 at 4:11 PM
inaccurate DNA art of the day:
gives new meaning to "DNA damage"
November 25, 2024 at 5:03 PM
Very small RNA-reactive reagents can map RNA in crowded spaces in the cell -
congrats to Dr. Lu Xiao!
doi: 10.1016/j.chembiol.2024.09.009
November 25, 2024 at 4:53 PM