@khanhtrang.bsky.social
🧬Autoimmunity research dropped! We gave T cells a DNA map and found genes (like FDFT1) causing trouble. Half the targets are shared—these diseases are coordinated! Validate new drug target: squalene synthase. Thanks, team! My lymphocytes salute you. #Immunology
Congratulations to @khanhtrang.bsky.social. Delighted to contribute to this V2G across ~60 cell types & 15 autoimmune GWAS reports. @chopresearch.bsky.social @penngenetics.bsky.social
Congratulations to lead authors Trang, Sharma & Cook on our new Genome Biology study with the Grant, Romberg & Levings labs. V2G across ~60 cell types & 15 autoimmune GWAS
link.springer.com/article/10.1...
link.springer.com/article/10.1...
December 8, 2025 at 6:07 PM
🧬Autoimmunity research dropped! We gave T cells a DNA map and found genes (like FDFT1) causing trouble. Half the targets are shared—these diseases are coordinated! Validate new drug target: squalene synthase. Thanks, team! My lymphocytes salute you. #Immunology
Reposted
Congratulations to @khanhtrang.bsky.social. Delighted to contribute to this V2G across ~60 cell types & 15 autoimmune GWAS reports. @chopresearch.bsky.social @penngenetics.bsky.social
Congratulations to lead authors Trang, Sharma & Cook on our new Genome Biology study with the Grant, Romberg & Levings labs. V2G across ~60 cell types & 15 autoimmune GWAS
link.springer.com/article/10.1...
link.springer.com/article/10.1...
3D chromatin-based variant-to-gene maps across 57 human cell types reveal the cellular and genetic architecture of autoimmune disease susceptibility - Genome Biology
Genome Biology - Insight into the genetic basis for many common autoimmune disorders has been uncovered by genome-wide association studies (GWAS), but this alone does not reveal causal variants,...
link.springer.com
December 8, 2025 at 3:52 PM
Congratulations to @khanhtrang.bsky.social. Delighted to contribute to this V2G across ~60 cell types & 15 autoimmune GWAS reports. @chopresearch.bsky.social @penngenetics.bsky.social
Reposted
ft. K. Trang, M. Pahl, J. Pippin, C. Su, S. Littleton, P. Sharma, N. Kulkarni, L. Ghanem, N. Terry, S. Anderson, B. Zemel, @alessandrachesi.bsky.social A. Wells, @struangrant.bsky.social, J. O'Brien, W. Yang, @ptitchenell.bsky.social P. Seale & @kkaestner.bsky.social elifesciences.org/articles/95411
January 23, 2025 at 3:20 PM
ft. K. Trang, M. Pahl, J. Pippin, C. Su, S. Littleton, P. Sharma, N. Kulkarni, L. Ghanem, N. Terry, S. Anderson, B. Zemel, @alessandrachesi.bsky.social A. Wells, @struangrant.bsky.social, J. O'Brien, W. Yang, @ptitchenell.bsky.social P. Seale & @kkaestner.bsky.social elifesciences.org/articles/95411
Reposted
Khanh Trang in our @elife.bsky.social paper integrates 3D genomic maps for >50 diverse cell types with pediatric obesity GWAS. Findings implicate a role for pancreatic islet cell types. Our #V2G mapping nominates effector genes. @penngenetics.bsky.social
doi.org/10.7554/eLif...
doi.org/10.7554/eLif...
January 16, 2025 at 12:38 PM
Khanh Trang in our @elife.bsky.social paper integrates 3D genomic maps for >50 diverse cell types with pediatric obesity GWAS. Findings implicate a role for pancreatic islet cell types. Our #V2G mapping nominates effector genes. @penngenetics.bsky.social
doi.org/10.7554/eLif...
doi.org/10.7554/eLif...