Kerstin Göpfrich
@kgoepfrich.bsky.social
Excited to engineer a synthetic cell from scratch with lipid vesicles and DNA/RNA origami-based molecular hardware. Professor @ZMBHh @UniHeidelberg
Curious about RNA, aptamers, lipid membranes, molecular dynamics simulations, synthetic cells - and how these topics come together? Join @floppleton.bsky.social's talk in the unano webinar blogs.ed.ac.uk/unanowebinars
September 8, 2025 at 2:59 PM
Curious about RNA, aptamers, lipid membranes, molecular dynamics simulations, synthetic cells - and how these topics come together? Join @floppleton.bsky.social's talk in the unano webinar blogs.ed.ac.uk/unanowebinars
RNA droplets that grow and segregate by ribozyme catalysis. Check out our latest preprint www.biorxiv.org/content/10.1101/2025.08.29.673008v1
September 2, 2025 at 7:03 AM
RNA droplets that grow and segregate by ribozyme catalysis. Check out our latest preprint www.biorxiv.org/content/10.1101/2025.08.29.673008v1
@tranmai.bsky.social handed in her PhD thesis! Celebrating in style with egg coffee from Hanoi, Mai's place of birth. P.S.: Mai is looking for a PostDoc position! Check out her latest RNA nanostructures for synthetic cells @natnano.nature.com doi.org/10.1038/s415...
August 1, 2025 at 10:48 AM
@tranmai.bsky.social handed in her PhD thesis! Celebrating in style with egg coffee from Hanoi, Mai's place of birth. P.S.: Mai is looking for a PostDoc position! Check out her latest RNA nanostructures for synthetic cells @natnano.nature.com doi.org/10.1038/s415...
Preprint by @towalther.bsky.social at al! We design DNA hydrogel microparticles with sequence-controlled stiffness from 30 Pa to 6.5 kPa. They are remodelled in fibroblast spheroids www.biorxiv.org/content/10.1... Thanks @ibecbarcelona.eu @xaviertrepat.bsky.social @pcusachs.bsky.social
July 28, 2025 at 7:35 AM
Preprint by @towalther.bsky.social at al! We design DNA hydrogel microparticles with sequence-controlled stiffness from 30 Pa to 6.5 kPa. They are remodelled in fibroblast spheroids www.biorxiv.org/content/10.1... Thanks @ibecbarcelona.eu @xaviertrepat.bsky.social @pcusachs.bsky.social
New Master's programme in Heidelberg! Please share with interested students
January 30, 2025 at 12:17 PM
New Master's programme in Heidelberg! Please share with interested students
What happens when you apply design principles from bottom-up synthetic biology to immunology? In Heidelberg and together with @FrischknechtLab @platten_michael & Oliver Fackler we compiled the prospects of bottom-up synthetic immunology @NatureNano https://rdcu.be/dR0r0
November 20, 2024 at 4:13 PM
What happens when you apply design principles from bottom-up synthetic biology to immunology? In Heidelberg and together with @FrischknechtLab @platten_michael & Oliver Fackler we compiled the prospects of bottom-up synthetic immunology @NatureNano https://rdcu.be/dR0r0
@ToWalther presenting our DNA microbeads that he used to generate morphogen gradients in organoids together with @AftingCassian @WittbrodtLab 🤩 @Cluster3DMM2O
November 20, 2024 at 4:25 PM
@ToWalther presenting our DNA microbeads that he used to generate morphogen gradients in organoids together with @AftingCassian @WittbrodtLab 🤩 @Cluster3DMM2O
Hopefully they are not eaten alive on the red carpet!
November 21, 2024 at 4:30 PM
Hopefully they are not eaten alive on the red carpet!
Fantastic talk by @CavalcantiAda at #EBSA2023 on receptor-mediated regulation of cell mechanics. Here are the references for our collaboration on the DNA nanotech tools if you want to give them a try: https://www.cell.com/trends/biotechnology/fulltext/S0167-7799(21)00034-2...
November 21, 2024 at 4:31 PM
Fantastic talk by @CavalcantiAda at #EBSA2023 on receptor-mediated regulation of cell mechanics. Here are the references for our collaboration on the DNA nanotech tools if you want to give them a try: https://www.cell.com/trends/biotechnology/fulltext/S0167-7799(21)00034-2...
Tomorrow we will be discussing if there are ways to make our research more sustainable. Please join us @mpi_mr_hd or via zoom: https://eu02web.zoom.us/webinar/register/WN_1uRfWlxjSLOlMImfoR1roA#/registration Thanks @majaillig and Jan Heidelberger for initiating this!
November 21, 2024 at 4:50 PM
Tomorrow we will be discussing if there are ways to make our research more sustainable. Please join us @mpi_mr_hd or via zoom: https://eu02web.zoom.us/webinar/register/WN_1uRfWlxjSLOlMImfoR1roA#/registration Thanks @majaillig and Jan Heidelberger for initiating this!
Thank you to an anonymous reviewer who recommended this book on the origins of life. Absolutely beautifully written, captivating and full of intersting thoughts.
November 21, 2024 at 4:57 PM
Thank you to an anonymous reviewer who recommended this book on the origins of life. Absolutely beautifully written, captivating and full of intersting thoughts.
We all like to make functional structures from DNA origami. Here is a new function by Monari et al. Thanks @monari_luca!
November 21, 2024 at 5:19 PM
We all like to make functional structures from DNA origami. Here is a new function by Monari et al. Thanks @monari_luca!
We built DNA-based mimicks of cytoskeletal filaments capable of reversible assembly and cargo transport inside cell-sized compartments. Now out @NatureChemistry! https://www.nature.com/articles/s41557-022-00945-w
November 21, 2024 at 5:38 PM
We built DNA-based mimicks of cytoskeletal filaments capable of reversible assembly and cargo transport inside cell-sized compartments. Now out @NatureChemistry! https://www.nature.com/articles/s41557-022-00945-w
Dear #SynCell'ers: What would you say was the biggest breakthrough publication for the field in the past decade? We have the chance to feature it in a special issue @TrendsinBiotech. Let's decide as a community. Please RT and reply! @buildacell @SynCellEU @iGEMCommunity
November 21, 2024 at 5:38 PM
Dear #SynCell'ers: What would you say was the biggest breakthrough publication for the field in the past decade? We have the chance to feature it in a special issue @TrendsinBiotech. Let's decide as a community. Please RT and reply! @buildacell @SynCellEU @iGEMCommunity
To the successes of the last three years! Congrats @KeJahnke! IF = %alc.
November 21, 2024 at 5:45 PM
To the successes of the last three years! Congrats @KeJahnke! IF = %alc.
3D printing goes 3D archery! @Cluster3DMM2O
November 21, 2024 at 5:50 PM
3D printing goes 3D archery! @Cluster3DMM2O
How can you build up structures on the inside of synthetic cells? With 3D laser printing. Very excited to share this work by @ToAbele et al @Cluster3DMM2O in Advanced Materials https://onlinelibrary.wiley.com/doi/abs/10.1002/adma.202106709
November 21, 2024 at 6:08 PM
How can you build up structures on the inside of synthetic cells? With 3D laser printing. Very excited to share this work by @ToAbele et al @Cluster3DMM2O in Advanced Materials https://onlinelibrary.wiley.com/doi/abs/10.1002/adma.202106709
Now @NatureComms: We realize a reaction pathway for synthetic cells that involves light-harvesting E. coli, pH-sensitive DNA origami and lipid vesicles https://www.nature.com/articles/s41467-021-24103-x
November 21, 2024 at 6:31 PM
Now @NatureComms: We realize a reaction pathway for synthetic cells that involves light-harvesting E. coli, pH-sensitive DNA origami and lipid vesicles https://www.nature.com/articles/s41467-021-24103-x
We find that the choice of fluorophore can alter or completely inhibit dynamics of DNA structures. Now out @NAR_Open https://doi.org/10.1093/nar/gkab201 @KeJahnke @max_igaev @CompBioPhys
November 21, 2024 at 6:37 PM
We find that the choice of fluorophore can alter or completely inhibit dynamics of DNA structures. Now out @NAR_Open https://doi.org/10.1093/nar/gkab201 @KeJahnke @max_igaev @CompBioPhys
In the review, we discuss pros and cons of different membrane anchoring strategies. Check out Table 1 for guidance on the choice for specific applications https://authors.elsevier.com/a/1cjjPc9XEbtUM
November 21, 2024 at 6:49 PM
In the review, we discuss pros and cons of different membrane anchoring strategies. Check out Table 1 for guidance on the choice for specific applications https://authors.elsevier.com/a/1cjjPc9XEbtUM
"The best way to ensure practical usefulness is not to worry about usefulness." 👇💪
November 21, 2024 at 6:43 PM
"The best way to ensure practical usefulness is not to worry about usefulness." 👇💪
WANTED: A #postdoc with experience in DNA origami or high-speed AFM, data analysis & a strong interest in synthetic biology. Join a friendly & motivated group @mpi_mr_hd @Cluster3DMM2O in Heidelberg. Happy to help with fellowship applications. Please RT! http://www.goepfrichgroup.de
November 21, 2024 at 6:49 PM
WANTED: A #postdoc with experience in DNA origami or high-speed AFM, data analysis & a strong interest in synthetic biology. Join a friendly & motivated group @mpi_mr_hd @Cluster3DMM2O in Heidelberg. Happy to help with fellowship applications. Please RT! http://www.goepfrichgroup.de
Dividing christmas baubles (i.e. GUVs) and their regrowth - online just on time @angew_chem https://onlinelibrary.wiley.com/doi/10.1002/ange.202014174 We divide phase-separated GUVs with enzymatic reactions or locally with light & describe the process with an analytical model....
November 21, 2024 at 6:56 PM
Dividing christmas baubles (i.e. GUVs) and their regrowth - online just on time @angew_chem https://onlinelibrary.wiley.com/doi/10.1002/ange.202014174 We divide phase-separated GUVs with enzymatic reactions or locally with light & describe the process with an analytical model....
Happy birthday @Gates_Cambridge! Thank you for the support, and cheers to all friends around the world @GatesAlumni Sharing memories form the Lake District. #gatescambridge20
November 21, 2024 at 7:13 PM
Happy birthday @Gates_Cambridge! Thank you for the support, and cheers to all friends around the world @GatesAlumni Sharing memories form the Lake District. #gatescambridge20
Our IT is clearly on top of their game! @mpi_mr_hd
November 21, 2024 at 7:13 PM
Our IT is clearly on top of their game! @mpi_mr_hd