@kausthubh.bsky.social
(he/him) PhD student at EMBL Heidelberg | phylogenetics | evolutionary cell biology | Views personal
Reposted
Curious about how this story came to be (we never planned to study centromeres!)? Here’s a glimpse behind the scenes of how a naive method to count chromosomes unlocked the rules behind centromere evolution.
P.S. There are cartoons!
👉 tinyurl.com/4rz4ve6u
P.S. There are cartoons!
👉 tinyurl.com/4rz4ve6u
Counting Chromosomes: The Simple Idea That Unlocked the Rules Behind Centromere Evolution
tinyurl.com
November 26, 2025 at 4:27 PM
Curious about how this story came to be (we never planned to study centromeres!)? Here’s a glimpse behind the scenes of how a naive method to count chromosomes unlocked the rules behind centromere evolution.
P.S. There are cartoons!
👉 tinyurl.com/4rz4ve6u
P.S. There are cartoons!
👉 tinyurl.com/4rz4ve6u
Reposted
PCAn, our point centromere annotation tool 🔍 was also updated! Try it out with your own genome assemblies and let us know what you think!
👉 github.com/JHelsen/point-centromere-detection
👉 github.com/JHelsen/point-centromere-detection
GitHub - JHelsen/point-centromere-detection: This repository contains all the instructions and code required to perform the analyses used in this study - https://www.biorxiv.org/content/10.1101/2025.0...
This repository contains all the instructions and code required to perform the analyses used in this study - https://www.biorxiv.org/content/10.1101/2025.01.16.633479v1 - JHelsen/point-centromere-d...
github.com
November 26, 2025 at 4:24 PM
PCAn, our point centromere annotation tool 🔍 was also updated! Try it out with your own genome assemblies and let us know what you think!
👉 github.com/JHelsen/point-centromere-detection
👉 github.com/JHelsen/point-centromere-detection
Reposted
(3/3) The researchers found that the cell’s division machinery acts as a critical filter, allowing only those centromere variants that are compatible with effective attachment to survive and spread.
@gautamdey.bsky.social @helsenjana.bsky.social @gsherloc.bsky.social @kausthubh.bsky.social
@gautamdey.bsky.social @helsenjana.bsky.social @gsherloc.bsky.social @kausthubh.bsky.social
Progressive coevolution of the yeast centromere and kinetochore | Nature
www.nature.com
November 26, 2025 at 4:06 PM
(3/3) The researchers found that the cell’s division machinery acts as a critical filter, allowing only those centromere variants that are compatible with effective attachment to survive and spread.
@gautamdey.bsky.social @helsenjana.bsky.social @gsherloc.bsky.social @kausthubh.bsky.social
@gautamdey.bsky.social @helsenjana.bsky.social @gsherloc.bsky.social @kausthubh.bsky.social
Reposted
9. TL;DR + link dump
WitChi is:
✔ Fast
✔ Interpretable
✔ Tree- and model-free
✔ Benchmark-validated
Designed to fix compositional bias at phylogenomic scale.
With: @kassipan.bsky.social, @danieltamarit.bsky.social, @ettema.bsky.social
💻 github.com/stephkoest/w...
📄 www.biorxiv.org/content/10.1...
WitChi is:
✔ Fast
✔ Interpretable
✔ Tree- and model-free
✔ Benchmark-validated
Designed to fix compositional bias at phylogenomic scale.
With: @kassipan.bsky.social, @danieltamarit.bsky.social, @ettema.bsky.social
💻 github.com/stephkoest/w...
📄 www.biorxiv.org/content/10.1...
GitHub - stephkoest/witchi: A compositional bias testing and pruning tool for multiple sequence alignments
A compositional bias testing and pruning tool for multiple sequence alignments - stephkoest/witchi
github.com
July 20, 2025 at 1:04 PM
9. TL;DR + link dump
WitChi is:
✔ Fast
✔ Interpretable
✔ Tree- and model-free
✔ Benchmark-validated
Designed to fix compositional bias at phylogenomic scale.
With: @kassipan.bsky.social, @danieltamarit.bsky.social, @ettema.bsky.social
💻 github.com/stephkoest/w...
📄 www.biorxiv.org/content/10.1...
WitChi is:
✔ Fast
✔ Interpretable
✔ Tree- and model-free
✔ Benchmark-validated
Designed to fix compositional bias at phylogenomic scale.
With: @kassipan.bsky.social, @danieltamarit.bsky.social, @ettema.bsky.social
💻 github.com/stephkoest/w...
📄 www.biorxiv.org/content/10.1...