#HFSP and #EMBO Fellow
Cheers!
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Cheers!
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Huge thanks to the authors behind all the foundational studies that inspired this work, to my amazing advisors (@apeyrache.bsky.social and Stuart Trenholm), and to the brilliant members of the Peyrache and Trenholm labs for their support.
Huge thanks to the authors behind all the foundational studies that inspired this work, to my amazing advisors (@apeyrache.bsky.social and Stuart Trenholm), and to the brilliant members of the Peyrache and Trenholm labs for their support.
In summary, we provide a direct link between stereo olfaction and the HD system in blind mice, and highlight the contribution of HD cells to allocentric spatial navigation.
In summary, we provide a direct link between stereo olfaction and the HD system in blind mice, and highlight the contribution of HD cells to allocentric spatial navigation.
We also tested blind mice with bilateral ablation of olfactory sensory neurons on the task.
And as expected, their performance tanked!
We also tested blind mice with bilateral ablation of olfactory sensory neurons on the task.
And as expected, their performance tanked!
Interestingly, during rewarded trials, mice with one nostril blocked adopted a "hunting" strategy: scanning until they randomly hit the target, then used self-motion cues to secure extra rewards. However, once they strayed too far, they were unable to relocate the target.
Interestingly, during rewarded trials, mice with one nostril blocked adopted a "hunting" strategy: scanning until they randomly hit the target, then used self-motion cues to secure extra rewards. However, once they strayed too far, they were unable to relocate the target.
However, blind mice with one nostril blocked struggled, and often waited at random angles. This breakdown was pronounced in probe trials.
However, blind mice with one nostril blocked struggled, and often waited at random angles. This breakdown was pronounced in probe trials.
Blind control mice quickly mastered the task and maintained their head at the correct target angle even during unrewarded probe trials.
Blind control mice quickly mastered the task and maintained their head at the correct target angle even during unrewarded probe trials.