John Belmont
@jwbelmon.bsky.social
#MD, #PhD | #Pediatrics | #Medical #Genetics | #Human #Genetics | #Cardiovascular | #Congenital | #Genome #Sequencing | #HealthEcon | #Causal #Inference
belmontgenetics.org
belmontgenetics.org
Pinned
John Belmont
@jwbelmon.bsky.social
· Aug 19
The Causal Pivot: A structural approach to genetic heterogeneity and variant discovery in complex diseases
We present the Causal Pivot (CP) as a structural causal model (SCM) for analyzing genetic heterogeneity in complex diseases. The CP leverages an estab…
www.sciencedirect.com
Causal Pivot is an idea that comes from differential diagnosis in medical practice www.sciencedirect.com/science/arti... Chad Shaw and I drew DAGs for molecular diagnosis and gene discovery. He saw an opportunity to exploit collider bias in an interesting way.
Reposted by John Belmont
The work of Sue Welfare, contemporary UK printmaker #ReframingWomenPrintmaker
November 13, 2025 at 8:36 AM
The work of Sue Welfare, contemporary UK printmaker #ReframingWomenPrintmaker
Reposted by John Belmont
6/ We also have some good news on the vaccine front. Ahead of the next ACIP meeting, the independent Vaccine Integrity Project (VIP) is reviewing evidence on Hep B. VIP is an independent group of scientists formed in response to waning trust in RFK Jr.’s ACIP.
November 11, 2025 at 7:25 PM
6/ We also have some good news on the vaccine front. Ahead of the next ACIP meeting, the independent Vaccine Integrity Project (VIP) is reviewing evidence on Hep B. VIP is an independent group of scientists formed in response to waning trust in RFK Jr.’s ACIP.
Reposted by John Belmont
2/ First up, the American Academy of Pediatrics (AAP) is standing up for science. The AAP is suing HHS Sec. RFK Jr., arguing that his vaccine advisory panel (ACIP) should be dissolved. The lawsuit also seeks to overturn the panel’s recent decisions.
November 11, 2025 at 7:25 PM
2/ First up, the American Academy of Pediatrics (AAP) is standing up for science. The AAP is suing HHS Sec. RFK Jr., arguing that his vaccine advisory panel (ACIP) should be dissolved. The lawsuit also seeks to overturn the panel’s recent decisions.
Reposted by John Belmont
We need more institutions like the American Academy of Pediatrics to stand up and fight for science and medicine.
Pediatricians are the best of us in the house of medicine, our backbone fighting to defend all of us and doing it with sunshine and rainbows and silly flashlights on their stethoscopes.
Pediatricians are the best of us in the house of medicine, our backbone fighting to defend all of us and doing it with sunshine and rainbows and silly flashlights on their stethoscopes.
2/ First up, the American Academy of Pediatrics (AAP) is standing up for science. The AAP is suing HHS Sec. RFK Jr., arguing that his vaccine advisory panel (ACIP) should be dissolved. The lawsuit also seeks to overturn the panel’s recent decisions.
November 12, 2025 at 7:11 PM
We need more institutions like the American Academy of Pediatrics to stand up and fight for science and medicine.
Pediatricians are the best of us in the house of medicine, our backbone fighting to defend all of us and doing it with sunshine and rainbows and silly flashlights on their stethoscopes.
Pediatricians are the best of us in the house of medicine, our backbone fighting to defend all of us and doing it with sunshine and rainbows and silly flashlights on their stethoscopes.
Reposted by John Belmont
The Matthew Effect is alive and well in academia - always makes me wary of programs aimed at identifying rising stars in an already highly talented pool...
elifesciences.org/reviewed-pre...
elifesciences.org/reviewed-pre...
elifesciences.org
November 12, 2025 at 7:03 PM
The Matthew Effect is alive and well in academia - always makes me wary of programs aimed at identifying rising stars in an already highly talented pool...
elifesciences.org/reviewed-pre...
elifesciences.org/reviewed-pre...
Reposted by John Belmont
Stay tuned here for upcoming updates to pgsc_calc (github.com/PGScatalog/p...), our tool for reproducible PGS calculation. Our next version aims to increase the scalability to WGS data in cloud trusted research environments (e.g. All of Us).
GitHub - PGScatalog/pgsc_calc: The Polygenic Score Catalog Calculator is a nextflow pipeline for polygenic score calculation
The Polygenic Score Catalog Calculator is a nextflow pipeline for polygenic score calculation - PGScatalog/pgsc_calc
github.com
November 11, 2025 at 5:43 PM
Stay tuned here for upcoming updates to pgsc_calc (github.com/PGScatalog/p...), our tool for reproducible PGS calculation. Our next version aims to increase the scalability to WGS data in cloud trusted research environments (e.g. All of Us).
Reposted by John Belmont
{report} #rstats package version 0.6.2 is now on CRAN!
MANY bug fixes in this version! Including corrected duplicated text outputs and dramatic speed increases for brmsfit models (which used to refit the model entirely every time).
easystats.github.io/report/
With the @easystats.github.io team
MANY bug fixes in this version! Including corrected duplicated text outputs and dramatic speed increases for brmsfit models (which used to refit the model entirely every time).
easystats.github.io/report/
With the @easystats.github.io team
Automated Reporting of Results and Statistical Models
The aim of the report package is to bridge the gap between R’s output and the formatted results contained in your manuscript. This package converts statistical models and data frames into textual repo...
easystats.github.io
November 8, 2025 at 11:07 PM
{report} #rstats package version 0.6.2 is now on CRAN!
MANY bug fixes in this version! Including corrected duplicated text outputs and dramatic speed increases for brmsfit models (which used to refit the model entirely every time).
easystats.github.io/report/
With the @easystats.github.io team
MANY bug fixes in this version! Including corrected duplicated text outputs and dramatic speed increases for brmsfit models (which used to refit the model entirely every time).
easystats.github.io/report/
With the @easystats.github.io team
Reposted by John Belmont
Reposted by John Belmont
In its first year tidyplots.org has become the go-to data viz for many life science researchers, got 620+ stars on Github, ~30K CRAN downloads, and 11 citations. Thank you for using, sharing, citing, and feedback! There is more to come 🤩
#rstats #dataviz #phd
#rstats #dataviz #phd
November 8, 2025 at 9:24 AM
In its first year tidyplots.org has become the go-to data viz for many life science researchers, got 620+ stars on Github, ~30K CRAN downloads, and 11 citations. Thank you for using, sharing, citing, and feedback! There is more to come 🤩
#rstats #dataviz #phd
#rstats #dataviz #phd
Reposted by John Belmont
@brielin.bsky.social's fantastic work on causal gene network inference from Perturb-seq is published! We estimate total causal effects using guides as instruments, then deconvolve into direct & mediated effects with a directed analog of graphical lasso. Deets: nature.com/articles/s41467-025-64353-7
Large-scale causal discovery using interventional data sheds light on gene network structure in k562 cells - Nature Communications
The authors give a method for learning causal gene networks using Perturb-seq data. In K562 cells, they find a network with small-world and scale-free properties. Analysis shows a relationship between...
nature.com
November 3, 2025 at 7:09 PM
@brielin.bsky.social's fantastic work on causal gene network inference from Perturb-seq is published! We estimate total causal effects using guides as instruments, then deconvolve into direct & mediated effects with a directed analog of graphical lasso. Deets: nature.com/articles/s41467-025-64353-7
Reposted by John Belmont
The ceramics of Acoma artist Barbara Cerno, who was born in Acoma Pueblo in 1959 #WomensArt
November 6, 2025 at 5:02 AM
The ceramics of Acoma artist Barbara Cerno, who was born in Acoma Pueblo in 1959 #WomensArt
Reposted by John Belmont
Vancouver has the most beautiful maintenance covers. Some of these cast iron medallions cover public works (drains, sewers) and some are purely decorative 😍 This design is by Musqueam artist Susan Point (1995).
November 6, 2025 at 5:55 PM
Vancouver has the most beautiful maintenance covers. Some of these cast iron medallions cover public works (drains, sewers) and some are purely decorative 😍 This design is by Musqueam artist Susan Point (1995).
Reposted by John Belmont
Not me but my gf had an infection & saw her regular dr she’s been seeing for years & tho he knew she was allergic to cillins (like amoxicillin or penicillin) prescribed one & she couldn’t breathe, had to go to the er, & when she asked WHY?! He told her “I didn’t think you were *rly* allergic”
Of late, I’ve been failed by my oncologist & dentist (after previously being failed by geneticist, GI specialist & mammograms that aren’t any good for dense tissue but they don’t tell you it’s a waste of time till you prove it).
QUESTION: if I wrote a series on Medium med + women would you read it?
QUESTION: if I wrote a series on Medium med + women would you read it?
So, an update. Dentist removed an old filling and discovers the crack I told him was there a month ago. But since he didn’t believe me, and we left it (despite my going to him twice in the interim), decay had set in and the nerve is now inflamed. It’s possible I’ll need a root canal now. FFS.
November 4, 2025 at 12:20 PM
Not me but my gf had an infection & saw her regular dr she’s been seeing for years & tho he knew she was allergic to cillins (like amoxicillin or penicillin) prescribed one & she couldn’t breathe, had to go to the er, & when she asked WHY?! He told her “I didn’t think you were *rly* allergic”
Reposted by John Belmont
Improved genomic characterization of a clinically heterogeneous pediatric cohort with WGS vs. WES. #WGS #WES #Sequencing #Genomics #Bioinformatics #ScientificReports 🧪🧬 🖥️
www.nature.com/articles/s41...
www.nature.com/articles/s41...
November 2, 2025 at 4:00 PM
Improved genomic characterization of a clinically heterogeneous pediatric cohort with WGS vs. WES. #WGS #WES #Sequencing #Genomics #Bioinformatics #ScientificReports 🧪🧬 🖥️
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by John Belmont
The Disease Ontology's October release is now available 🎉
Learn about the Disease Ontology's 11,985 disease classes and latest updates at github.com/DiseaseOntol...
#DiseaseResearch #Biocuration #Bioinformatics #FAIR #ComputationalBiology
Learn about the Disease Ontology's 11,985 disease classes and latest updates at github.com/DiseaseOntol...
#DiseaseResearch #Biocuration #Bioinformatics #FAIR #ComputationalBiology
Release DO October 2025 Release · DiseaseOntology/HumanDiseaseOntology
This release of the Human Disease Ontology includes 11,985 disease classes, 9,698 with textual definitions (80.9%). Translation files now include 11,582 labels (96.6%), 11,490 synonyms (59.2%), and...
github.com
November 3, 2025 at 3:41 PM
The Disease Ontology's October release is now available 🎉
Learn about the Disease Ontology's 11,985 disease classes and latest updates at github.com/DiseaseOntol...
#DiseaseResearch #Biocuration #Bioinformatics #FAIR #ComputationalBiology
Learn about the Disease Ontology's 11,985 disease classes and latest updates at github.com/DiseaseOntol...
#DiseaseResearch #Biocuration #Bioinformatics #FAIR #ComputationalBiology
Reposted by John Belmont
Nothing to see here but a cop trying to run down and murder someone with his police SUV because his feelings were hurt. As @gregdoucette.bsky.social would say, cops are great.
October 29, 2025 at 8:28 PM
Nothing to see here but a cop trying to run down and murder someone with his police SUV because his feelings were hurt. As @gregdoucette.bsky.social would say, cops are great.
Reposted by John Belmont
Statistical Rethinking with brms, ggplot2, and the tidyverse Second edition by A Solomon Kurz
#RStats
https://bigbookofr.com/chapters/statistics.html#statistical-rethinking-with-brms-ggplot2-and-the-tidyverse-second-edition
#RStats
https://bigbookofr.com/chapters/statistics.html#statistical-rethinking-with-brms-ggplot2-and-the-tidyverse-second-edition
October 29, 2025 at 1:49 AM
Statistical Rethinking with brms, ggplot2, and the tidyverse Second edition by A Solomon Kurz
#RStats
https://bigbookofr.com/chapters/statistics.html#statistical-rethinking-with-brms-ggplot2-and-the-tidyverse-second-edition
#RStats
https://bigbookofr.com/chapters/statistics.html#statistical-rethinking-with-brms-ggplot2-and-the-tidyverse-second-edition
Reposted by John Belmont
The program for #CDSM2025 is now live! Join us online this November for two days of talks and discussions on #Causality, #DataScience, and #AI. 🚨👇
🎉 The program for this year's Causal Data Science Meeting (#CDSM2025) is now live!
📅 Nov 12–13, 2025 | 💻 Online | 🎟️ Free registration
Join us for two days of talks and debates at the intersection of causality, data science, and AI.
👉 causalscience.org
📅 Nov 12–13, 2025 | 💻 Online | 🎟️ Free registration
Join us for two days of talks and debates at the intersection of causality, data science, and AI.
👉 causalscience.org
October 23, 2025 at 1:51 PM
The program for #CDSM2025 is now live! Join us online this November for two days of talks and discussions on #Causality, #DataScience, and #AI. 🚨👇
Reposted by John Belmont
Causal Inference is Not Just a Statistics Problem.
www.tandfonline.com/doi/full/10....
An introductory article including a primer on causal inference and DAGS , and accompanied by an r package containing simulated data to help explain concepts.
www.tandfonline.com/doi/full/10....
An introductory article including a primer on causal inference and DAGS , and accompanied by an r package containing simulated data to help explain concepts.
www.tandfonline.com
October 24, 2025 at 1:24 PM
Causal Inference is Not Just a Statistics Problem.
www.tandfonline.com/doi/full/10....
An introductory article including a primer on causal inference and DAGS , and accompanied by an r package containing simulated data to help explain concepts.
www.tandfonline.com/doi/full/10....
An introductory article including a primer on causal inference and DAGS , and accompanied by an r package containing simulated data to help explain concepts.
Reposted by John Belmont
This is an excellent review article discussing open questions/challenges in causality and causal inference. arxiv.org/pdf/2508.17099
October 22, 2025 at 8:17 PM
This is an excellent review article discussing open questions/challenges in causality and causal inference. arxiv.org/pdf/2508.17099
Reposted by John Belmont
A great blue heron, looking great.
Southeast Texas, October 04, 2025.
#Herons #Birds #Photography #NaturePhotography #BirdPhotography #BirdWatching
Southeast Texas, October 04, 2025.
#Herons #Birds #Photography #NaturePhotography #BirdPhotography #BirdWatching
October 10, 2025 at 2:16 AM
A great blue heron, looking great.
Southeast Texas, October 04, 2025.
#Herons #Birds #Photography #NaturePhotography #BirdPhotography #BirdWatching
Southeast Texas, October 04, 2025.
#Herons #Birds #Photography #NaturePhotography #BirdPhotography #BirdWatching
Reposted by John Belmont
The screenshots are so cool (discussed mortality up to the end of 2023)
Interview in late 2025 discusses excess deaths (estimated as 2% by the interviewee and attributed to long covid) and drops in mortality due to glp1ra estimated to be ~6% by 2030.
insurancenewsnet.com/innarticle/s...
Interview in late 2025 discusses excess deaths (estimated as 2% by the interviewee and attributed to long covid) and drops in mortality due to glp1ra estimated to be ~6% by 2030.
insurancenewsnet.com/innarticle/s...
October 8, 2025 at 2:50 AM
The screenshots are so cool (discussed mortality up to the end of 2023)
Interview in late 2025 discusses excess deaths (estimated as 2% by the interviewee and attributed to long covid) and drops in mortality due to glp1ra estimated to be ~6% by 2030.
insurancenewsnet.com/innarticle/s...
Interview in late 2025 discusses excess deaths (estimated as 2% by the interviewee and attributed to long covid) and drops in mortality due to glp1ra estimated to be ~6% by 2030.
insurancenewsnet.com/innarticle/s...
Reposted by John Belmont
I highly recommend this talk for anyone doing applied quantitative research! It was by far the best talk at #EuroCIM2025!
Happy to announce that I'll give a talk on how we can make rigorous causal inference more mainstream 📈
You can sign up for the Zoom link here: tinyurl.com/CIIG-JuliaRo...
You can sign up for the Zoom link here: tinyurl.com/CIIG-JuliaRo...
October 6, 2025 at 11:54 AM
I highly recommend this talk for anyone doing applied quantitative research! It was by far the best talk at #EuroCIM2025!
Reposted by John Belmont
Pediatrics has long endured a workforce shortage. Now the Trump administration’s crackdown on vaccines is turning a difficult profession into an impossible one. @katherinejwu.com spoke with pediatricians about the looming crisis their jobs may face:
Pediatricians Are Rapidly Losing Incentives to Offer Vaccines
The Trump administration’s crackdown is turning a difficult profession into an impossible one for some doctors.
bit.ly
October 5, 2025 at 12:45 PM
Pediatrics has long endured a workforce shortage. Now the Trump administration’s crackdown on vaccines is turning a difficult profession into an impossible one. @katherinejwu.com spoke with pediatricians about the looming crisis their jobs may face:
Reposted by John Belmont
An “immigration judge” is not an actual judge in the judicial branch. They are a DOJ employee.
As Judge Young, an actual judge, made clear in one of the truly essential parts of his Tuesday ruling. www.lawdork.com/p/judge-will...
As Judge Young, an actual judge, made clear in one of the truly essential parts of his Tuesday ruling. www.lawdork.com/p/judge-will...
October 2, 2025 at 3:34 AM
An “immigration judge” is not an actual judge in the judicial branch. They are a DOJ employee.
As Judge Young, an actual judge, made clear in one of the truly essential parts of his Tuesday ruling. www.lawdork.com/p/judge-will...
As Judge Young, an actual judge, made clear in one of the truly essential parts of his Tuesday ruling. www.lawdork.com/p/judge-will...