Journal of Thrombosis and Haemostasis
@jthjournal.bsky.social
The Journal of Thrombosis and Haemostasis (JTH) is the official journal of the ISTH. The mission of JTH is to advance science related to the important medical problems of thrombosis, bleeding disorders and vascular biology. #MedSky #HemeSky #CardioSky
🚨 New RPTH Journal Research Recap! Dive into the latest insights from recent articles.
Read ahead:
📄 Full article → lnkd.in/eRJQcZEV
💬 Commentary → lnkd.in/g-q5ZvAa
Register here: streamyard.com/watch/WB9QYXi3e3hH
This Research Recap is supported by an educational grant from Takeda.
Read ahead:
📄 Full article → lnkd.in/eRJQcZEV
💬 Commentary → lnkd.in/g-q5ZvAa
Register here: streamyard.com/watch/WB9QYXi3e3hH
This Research Recap is supported by an educational grant from Takeda.
October 16, 2025 at 12:08 AM
🚨 New RPTH Journal Research Recap! Dive into the latest insights from recent articles.
Read ahead:
📄 Full article → lnkd.in/eRJQcZEV
💬 Commentary → lnkd.in/g-q5ZvAa
Register here: streamyard.com/watch/WB9QYXi3e3hH
This Research Recap is supported by an educational grant from Takeda.
Read ahead:
📄 Full article → lnkd.in/eRJQcZEV
💬 Commentary → lnkd.in/g-q5ZvAa
Register here: streamyard.com/watch/WB9QYXi3e3hH
This Research Recap is supported by an educational grant from Takeda.
JTH is proudly supports @worldthrombosisday.bsky.social! Show your commitment to patient safety and awareness this #WorldThrombosisDay on October 13. Share this graphic or create your own image using the WTD Design Hub: www.worldthrombosisday.org/poster-builder/ #WTDay25
September 23, 2025 at 8:56 PM
JTH is proudly supports @worldthrombosisday.bsky.social! Show your commitment to patient safety and awareness this #WorldThrombosisDay on October 13. Share this graphic or create your own image using the WTD Design Hub: www.worldthrombosisday.org/poster-builder/ #WTDay25
Global EHR-based study shows ~6% of children with CHD develop VTE within a year post-surgery, with a 25% recurrence rate. Most cases involved LE-DVT. Highlights need for targeted thromboprophylaxis strategies in this high-risk population. #PedsCardio #Thrombosis www.jthjournal.org/article/S153...
June 29, 2025 at 2:02 PM
Global EHR-based study shows ~6% of children with CHD develop VTE within a year post-surgery, with a 25% recurrence rate. Most cases involved LE-DVT. Highlights need for targeted thromboprophylaxis strategies in this high-risk population. #PedsCardio #Thrombosis www.jthjournal.org/article/S153...
Amazing and thorough discussion on the ISTH Hemophilia Guidelines contents & methodology live at #ISTH2025
See this paper in JTHfor more deconstruction of the guidelines #hemophilia #hemesky
www.jthjournal.org/article/S153...
See this paper in JTHfor more deconstruction of the guidelines #hemophilia #hemesky
www.jthjournal.org/article/S153...
June 24, 2025 at 12:43 PM
Amazing and thorough discussion on the ISTH Hemophilia Guidelines contents & methodology live at #ISTH2025
See this paper in JTHfor more deconstruction of the guidelines #hemophilia #hemesky
www.jthjournal.org/article/S153...
See this paper in JTHfor more deconstruction of the guidelines #hemophilia #hemesky
www.jthjournal.org/article/S153...
Corticosteroids remain the go-to for managing transaminitis post-valoctocogene roxaparvovec in hemophilia A. Early, reactive treatment may help preserve FVIII levels. #GeneTherapy #HemophiliaA #HemeSky www.jthjournal.org/article/S153...
June 21, 2025 at 11:01 PM
Corticosteroids remain the go-to for managing transaminitis post-valoctocogene roxaparvovec in hemophilia A. Early, reactive treatment may help preserve FVIII levels. #GeneTherapy #HemophiliaA #HemeSky www.jthjournal.org/article/S153...
🩺 In the PAUSE-2 pilot trial, perioperative management of DOACs in patients undergoing high-bleed-risk surgery or neuraxial procedures was found feasible. Both ASRA- and PAUSE-based strategies achieved similar pre-op DOAC levels, supporting a larger trial.
www.jthjournal.org/article/S153...
www.jthjournal.org/article/S153...
June 21, 2025 at 2:03 PM
🩺 In the PAUSE-2 pilot trial, perioperative management of DOACs in patients undergoing high-bleed-risk surgery or neuraxial procedures was found feasible. Both ASRA- and PAUSE-based strategies achieved similar pre-op DOAC levels, supporting a larger trial.
www.jthjournal.org/article/S153...
www.jthjournal.org/article/S153...
Blocking tubulin detyrosination via VASH1-SVBP inhibition enhances proplatelet formation & boosts platelet counts—no impact on function. A novel understanding of the megakaryocyte tubulin code beyond tubulin isotypes. #Platelet #HemeSky www.jthjournal.org/article/S153...
June 19, 2025 at 2:05 PM
Blocking tubulin detyrosination via VASH1-SVBP inhibition enhances proplatelet formation & boosts platelet counts—no impact on function. A novel understanding of the megakaryocyte tubulin code beyond tubulin isotypes. #Platelet #HemeSky www.jthjournal.org/article/S153...
What are the barriers to recruitment and participation in RCTs evaluating postpartum thromboprophylaxis? This qualitative study reveals trust in providers, altruism, and risk perception as key motivators and barriers. Important insights for future trial design.
www.jthjournal.org/article/S153...
www.jthjournal.org/article/S153...
June 18, 2025 at 1:03 PM
What are the barriers to recruitment and participation in RCTs evaluating postpartum thromboprophylaxis? This qualitative study reveals trust in providers, altruism, and risk perception as key motivators and barriers. Important insights for future trial design.
www.jthjournal.org/article/S153...
www.jthjournal.org/article/S153...
How should women with AT deficiency be managed during pregnancy? This multicenter study shows that high-dose LMWH and peripartum AT concentrate may reduce venous thrombosis risk.
www.jthjournal.org/article/S153...
www.jthjournal.org/article/S153...
June 15, 2025 at 1:02 PM
How should women with AT deficiency be managed during pregnancy? This multicenter study shows that high-dose LMWH and peripartum AT concentrate may reduce venous thrombosis risk.
www.jthjournal.org/article/S153...
www.jthjournal.org/article/S153...
New study uncovers a zebrafish-specific interaction between TPO receptor (zTpoR) and Mapk14a (p38 MAPKα), crucial for thrombocyte development. This direct interaction, absent in humans, regulates thrombocyte count and clotting via unique signaling. #zebrafish
www.jthjournal.org/article/S153...
www.jthjournal.org/article/S153...
June 13, 2025 at 3:03 PM
New study uncovers a zebrafish-specific interaction between TPO receptor (zTpoR) and Mapk14a (p38 MAPKα), crucial for thrombocyte development. This direct interaction, absent in humans, regulates thrombocyte count and clotting via unique signaling. #zebrafish
www.jthjournal.org/article/S153...
www.jthjournal.org/article/S153...
Explore the #June2025 issue of JTH! Highlights: cancer-linked SVT, GPVI malfunction in young platelets, DOAC failure in VTE, and device-induced thrombosis insights. 🩸 jthjournal.org #VTE #hematology
June 11, 2025 at 8:15 PM
Explore the #June2025 issue of JTH! Highlights: cancer-linked SVT, GPVI malfunction in young platelets, DOAC failure in VTE, and device-induced thrombosis insights. 🩸 jthjournal.org #VTE #hematology
New data reveal a prothrombotic shift in cirrhosis: despite reduced plasmin generation, thrombin generation remains intact—creating a disbalance between coagulation and fibrinolysis. TG/PG ratio may be a novel marker of thrombotic risk. #cirrhosis #thrombosis
www.jthjournal.org/article/S153...
www.jthjournal.org/article/S153...
May 30, 2025 at 1:03 PM
New data reveal a prothrombotic shift in cirrhosis: despite reduced plasmin generation, thrombin generation remains intact—creating a disbalance between coagulation and fibrinolysis. TG/PG ratio may be a novel marker of thrombotic risk. #cirrhosis #thrombosis
www.jthjournal.org/article/S153...
www.jthjournal.org/article/S153...
🩸 In NSCLC patients starting chemo, elevated FXIa:AT and TAT levels predict VTE and mortality. A new biomarker-based score stratifies risk, offering a potential tool for early intervention. #NSCLC #VTE #oncology #thrombosis #HemeSky
www.jthjournal.org/article/S153...
www.jthjournal.org/article/S153...
May 28, 2025 at 1:03 PM
🩸 In NSCLC patients starting chemo, elevated FXIa:AT and TAT levels predict VTE and mortality. A new biomarker-based score stratifies risk, offering a potential tool for early intervention. #NSCLC #VTE #oncology #thrombosis #HemeSky
www.jthjournal.org/article/S153...
www.jthjournal.org/article/S153...
🧪 New findings challenge assumptions about young platelets: during stress thrombopoiesis, newly formed platelets show a transient defect in GPVI signaling. Full function appears to develop only after circulation time. #platelets #GPVI #hematology
May 27, 2025 at 2:04 PM
🧪 New findings challenge assumptions about young platelets: during stress thrombopoiesis, newly formed platelets show a transient defect in GPVI signaling. Full function appears to develop only after circulation time. #platelets #GPVI #hematology
🧪 Real-world study validates a new ADAMTS-13 assay: fast, reliable, and accurate for diagnosing and monitoring TTP. Strong performance at critical low activity levels makes it a valuable tool in clinical practice. #TTP #hematology #ADAMTS13 #labmedicine #MedSky
www.jthjournal.org/article/S153...
www.jthjournal.org/article/S153...
May 22, 2025 at 2:05 PM
🧪 Real-world study validates a new ADAMTS-13 assay: fast, reliable, and accurate for diagnosing and monitoring TTP. Strong performance at critical low activity levels makes it a valuable tool in clinical practice. #TTP #hematology #ADAMTS13 #labmedicine #MedSky
www.jthjournal.org/article/S153...
www.jthjournal.org/article/S153...
🧪 This study uncovers a novel aging-related thrombosis mechanism: Rpl13a snoRNAs in red blood cells drive ROS and venous thrombosis by silencing peroxidasin via 2ʹ-O-methylation. Knocking out these snoRNAs reduced thrombi in aged mice. #thrombosis #hematology
www.jthjournal.org/article/S153...
www.jthjournal.org/article/S153...
May 21, 2025 at 1:47 PM
🧪 This study uncovers a novel aging-related thrombosis mechanism: Rpl13a snoRNAs in red blood cells drive ROS and venous thrombosis by silencing peroxidasin via 2ʹ-O-methylation. Knocking out these snoRNAs reduced thrombi in aged mice. #thrombosis #hematology
www.jthjournal.org/article/S153...
www.jthjournal.org/article/S153...
⚠️ ISTH-SSC communication alert: Oral FXa inhibitors can interfere with heparin anti-Xa monitoring during therapy transitions. This may mislead anticoagulation management. This communication offers practical steps for UFH use. #anticoagulation
www.jthjournal.org/article/S153...
www.jthjournal.org/article/S153...
May 18, 2025 at 1:02 PM
⚠️ ISTH-SSC communication alert: Oral FXa inhibitors can interfere with heparin anti-Xa monitoring during therapy transitions. This may mislead anticoagulation management. This communication offers practical steps for UFH use. #anticoagulation
www.jthjournal.org/article/S153...
www.jthjournal.org/article/S153...
🫀 This recent review article explores why thrombosis remains a major challenge in mechanical circulatory support. Device surface properties & flow dynamics drive clot risk—offering opportunities for safer designs. #biomaterials #cardiology
www.jthjournal.org/article/S153...
www.jthjournal.org/article/S153...
May 17, 2025 at 1:03 PM
🫀 This recent review article explores why thrombosis remains a major challenge in mechanical circulatory support. Device surface properties & flow dynamics drive clot risk—offering opportunities for safer designs. #biomaterials #cardiology
www.jthjournal.org/article/S153...
www.jthjournal.org/article/S153...
In Impella-supported cardiogenic shock, discrepancies between anti-Xa and APTT during UFH therapy are common and linked to higher mortality—especially when paired with abnormal INR or low fibrinogen.
#MedSky #Criticalcare #HemeSky
www.jthjournal.org/article/S153...
#MedSky #Criticalcare #HemeSky
www.jthjournal.org/article/S153...
May 15, 2025 at 2:04 PM
In Impella-supported cardiogenic shock, discrepancies between anti-Xa and APTT during UFH therapy are common and linked to higher mortality—especially when paired with abnormal INR or low fibrinogen.
#MedSky #Criticalcare #HemeSky
www.jthjournal.org/article/S153...
#MedSky #Criticalcare #HemeSky
www.jthjournal.org/article/S153...
🧠 New network meta-analysis of 10,665 patients suggests dual antiplatelet therapy (aspirin + clopidogrel) may be the best option for minor stroke—more effective than aspirin or rt-PA, with lower bleeding and mortality risk. #stroke #neurology #DAPT #MedSky
www.jthjournal.org/article/S153...
www.jthjournal.org/article/S153...
May 14, 2025 at 2:47 PM
🧠 New network meta-analysis of 10,665 patients suggests dual antiplatelet therapy (aspirin + clopidogrel) may be the best option for minor stroke—more effective than aspirin or rt-PA, with lower bleeding and mortality risk. #stroke #neurology #DAPT #MedSky
www.jthjournal.org/article/S153...
www.jthjournal.org/article/S153...
🫀 New study compares heparin vs. PPC coatings in VA-ECMO: heparin-coated circuits showed fewer thrombotic events and distinct thrombi composition. PPC circuits had higher VWF content. Findings highlight coating type matters in ECMO outcomes. #MedSky #cardiology
www.jthjournal.org/article/S153...
www.jthjournal.org/article/S153...
May 10, 2025 at 2:02 PM
🫀 New study compares heparin vs. PPC coatings in VA-ECMO: heparin-coated circuits showed fewer thrombotic events and distinct thrombi composition. PPC circuits had higher VWF content. Findings highlight coating type matters in ECMO outcomes. #MedSky #cardiology
www.jthjournal.org/article/S153...
www.jthjournal.org/article/S153...
🚨 The ISTH SSC on DIC has released a major update to the definition & diagnostic criteria for DIC — the first since 2001.
Why it matters? Earlier detection. Better stratification. A path toward treatability.
#DIC #HemeSky #MedSky
🔗https://www.jthjournal.org/article/S1538-7836(25)00220-X/fulltext
Why it matters? Earlier detection. Better stratification. A path toward treatability.
#DIC #HemeSky #MedSky
🔗https://www.jthjournal.org/article/S1538-7836(25)00220-X/fulltext
May 7, 2025 at 12:27 AM
Central pulmonary embolism (cPE) is associated with a 2.2-fold increased risk of recurrent VTE, though not with overall mortality, compared to non-cPE. Short-term outcomes and PE-related quality of life were similar.
www.jthjournal.org/article/S153...
www.jthjournal.org/article/S153...
April 29, 2025 at 2:05 PM
Central pulmonary embolism (cPE) is associated with a 2.2-fold increased risk of recurrent VTE, though not with overall mortality, compared to non-cPE. Short-term outcomes and PE-related quality of life were similar.
www.jthjournal.org/article/S153...
www.jthjournal.org/article/S153...
Arterial thrombosis is an important complication in testicular germ cell tumor, associated with mortality. Short-term risk 📈 by cisplatin-based chemotherapy. Long-term risk can be stratified based on age ≥35, smoking, and elevated LDH.
www.jthjournal.org/article/S153...
www.jthjournal.org/article/S153...
April 27, 2025 at 1:01 PM
Arterial thrombosis is an important complication in testicular germ cell tumor, associated with mortality. Short-term risk 📈 by cisplatin-based chemotherapy. Long-term risk can be stratified based on age ≥35, smoking, and elevated LDH.
www.jthjournal.org/article/S153...
www.jthjournal.org/article/S153...
Using an ex vivo endothelialized model of HIT-induced thrombosis, this study demonstrates that IVIG significantly reduces thrombus formation and cellular adhesion triggered by HIT-IgG antibodies, validating the role of IVIG in HIT thrombosis.
#Hemesky #Medsky
www.jthjournal.org/article/S153...
#Hemesky #Medsky
www.jthjournal.org/article/S153...
April 26, 2025 at 1:04 PM
Using an ex vivo endothelialized model of HIT-induced thrombosis, this study demonstrates that IVIG significantly reduces thrombus formation and cellular adhesion triggered by HIT-IgG antibodies, validating the role of IVIG in HIT thrombosis.
#Hemesky #Medsky
www.jthjournal.org/article/S153...
#Hemesky #Medsky
www.jthjournal.org/article/S153...