Read the whole paper and more information about my research and ongoing projects at:

emiliomarmol.academicwebsite.com
www.cell.com/cell/fulltex...

Thanks Luisa! It was great to have you and James onboard! 😃

☕ Thanks for reading up to here!

I must say that both perspectives cited here make for a fantastic and thought-provoking weekend read with your favourite coffee.

Hope you enjoy exploring the hidden dimensions as much as we do!

END (10/10)

Personally, I got a lot of inspiration from this paper by @philipcball.bsky.social.
He highlights the complexity of biological systems and invites scientists to escape from the classical analogy of the genome as a recipe book with genes as its building blocks. (9/n)
www.cell.com/cell-systems...

We highlight several underexplored dimensions (among others):

🧩 Noncanonical chromosomes (B chromosomes, eccDNA)
🧠 3D genome architecture
🔁 Large-scale structural variation
💬 Transcript diversity & vQTLs
🌪️ Mutational potential

Each adds a new reflection in the “genomic kaleidoscope.”
(8/n)

We explore and showcase research done by all co-authors and others on how diversity in these hidden dimensions of the genome can affect phenotypes and adaptation.
(7/n)

This kaleidoscope can be thought of as the beautiful and complex image that can be obtained from studying the genome. DNA sequence at the center, yes, but true genome variation reveals a complex image of reflecting and interdependent features that we call dimensions.

Or hidden dimensions 👀

(6/n)

We invoke here the analogy of the (genomic) kaleidoscope.
(5/n)

(Cool drawing by Dr. Binia De Cahsan, @biobee.illustrations in IG 📸)

A few highlights from it, all included in our piece.

🧬 We go beyond the sequence: Genomic diversity isn’t only about nucleotide differences. We argue that other genomic features are equally central to understanding how genomes shape phenotypes.
(4/n)

So, it all started after we organised a symposium at the @official-smbe.bsky.social meeting in 2024, in Puerto Vallarta, Mexico 🇲🇽.
Together with all the speakers (all in the picture), we joined forces to write this Perspective for GBE, summarising the key ideas and results presented there.
(3/n)

Ok, but first things first... great collaboration effort together with: @aruizherrera.bsky.social @theafrogers.bsky.social @luisapallares.bsky.social, and many others not (yet) on Bluesky 🦋. Thanks everyone!
(2/n)

You can keep on gatekeeping us small fish, but know that we do good science and we will fight to keep publishing our good science. But also note that your gatekeeping has now cost Anais her whole career. If you're an Editor that did this - you kinda did that dude/dudette.

I particularly liked this.
"To create a true drug discovery engine, he believes we need half a dozen AlphaFold-level breakthroughs."
I mean, we *could* alternatively just do more science - but hell no, let's assume we just need to throw more AI at it.