Joost Snijder
@joostsnijder.bsky.social
a sort of scientist. viruses and antibodies. structure and biophysics. mass spec and cryoEM | Voorzitter SP Culemborg
Reposted by Joost Snijder
Explicit description of viral capsid subunit shapes by unfolding dihedrons by Ryuya Toyooka et al. www.nature.com/articles/s42...
Explicit description of viral capsid subunit shapes by unfolding dihedrons - Communications Biology
A proposed geometric framework describes and classifies all possible protein subunit shapes in viral capsids through spherical tiling theory, revealing different interaction patterns based on subunit ...
www.nature.com
November 29, 2025 at 10:00 AM
Explicit description of viral capsid subunit shapes by unfolding dihedrons by Ryuya Toyooka et al. www.nature.com/articles/s42...
Reposted by Joost Snijder
Featured #paper shows mechanism of #malaria infection blocking. Read "Cryo-EM structure of endogenous Pfs230:Pfs48/45 complex with 6 antibodies reveals mechanisms of malaria transmission-blocking" by @utoronto.ca using our CMCF beamline. https://bit.ly/47TWrVv 👈
Cryo-EM structure of endogenous Pfs230:Pfs48/45 complex with six antibodies reveals mechanisms of malaria transmission-blocking activity
The Pfs230:Pfs48/45 complex forms the basis for leading malaria transmission-blocking vaccine candidates, yet little is known about its molecular asse…
bit.ly
November 27, 2025 at 6:25 PM
Featured #paper shows mechanism of #malaria infection blocking. Read "Cryo-EM structure of endogenous Pfs230:Pfs48/45 complex with 6 antibodies reveals mechanisms of malaria transmission-blocking" by @utoronto.ca using our CMCF beamline. https://bit.ly/47TWrVv 👈
Reposted by Joost Snijder
How does fever work?
Our new Science paper shows how elevated body temperature can protect against severe influenza and that avian-origin viruses escape this defence.
This is likely one reason why bird flus and some pandemic influenzas can be so severe.🧵
www.science.org/doi/10.1126/...
Our new Science paper shows how elevated body temperature can protect against severe influenza and that avian-origin viruses escape this defence.
This is likely one reason why bird flus and some pandemic influenzas can be so severe.🧵
www.science.org/doi/10.1126/...
Avian-origin influenza A viruses tolerate elevated pyrexic temperatures in mammals
Host body temperature can define a virus’s replicative profile—influenza A viruses (IAVs) adapted to 40° to 42°C in birds are less temperature sensitive in vitro compared with human isolates adapted t...
www.science.org
November 27, 2025 at 7:55 PM
How does fever work?
Our new Science paper shows how elevated body temperature can protect against severe influenza and that avian-origin viruses escape this defence.
This is likely one reason why bird flus and some pandemic influenzas can be so severe.🧵
www.science.org/doi/10.1126/...
Our new Science paper shows how elevated body temperature can protect against severe influenza and that avian-origin viruses escape this defence.
This is likely one reason why bird flus and some pandemic influenzas can be so severe.🧵
www.science.org/doi/10.1126/...
Reposted by Joost Snijder
Vogelgriep trof nog nooit zoveel wilde vogels in Europa als dit seizoen. Sinds het begin van dit vogelgriepseizoen meldde de Europese Autoriteit voor Voedselveiligheid ruim 1.400 besmettingen onder dood aangetroffen wilde vogels, twee keer zoveel als in rampjaar 2022. buff.ly/4YBiuhr
In Europa waren nooit eerder zoveel wilde vogels besmet met vogelgriep
Vogelgriep: In vergelijking met dezelfde periode in ‘rampjaar’ 2022 zijn dit jaar zeker twee keer zoveel wilde vogels besmet met het virus. „Dit ziet er zeker niet goed uit.”
buff.ly
November 27, 2025 at 5:00 AM
Vogelgriep trof nog nooit zoveel wilde vogels in Europa als dit seizoen. Sinds het begin van dit vogelgriepseizoen meldde de Europese Autoriteit voor Voedselveiligheid ruim 1.400 besmettingen onder dood aangetroffen wilde vogels, twee keer zoveel als in rampjaar 2022. buff.ly/4YBiuhr
Reposted by Joost Snijder
Human coronavirus HKU1 neutralization by glycan receptor mimicry pubmed.ncbi.nlm.nih.gov/41278654/ #cryoem
November 26, 2025 at 5:17 AM
Human coronavirus HKU1 neutralization by glycan receptor mimicry pubmed.ncbi.nlm.nih.gov/41278654/ #cryoem
Reposted by Joost Snijder
Ballistic Microscopy (BaM) pubmed.ncbi.nlm.nih.gov/41279100/ #cryoem
November 26, 2025 at 1:04 AM
Ballistic Microscopy (BaM) pubmed.ncbi.nlm.nih.gov/41279100/ #cryoem
Reposted by Joost Snijder
It’s been a while since I put together the Structural Virology starter pack, and I’m sure some new folks have joined Bluesky since then. There’s still plenty of space to fill, so if you’d like to be added to the list just let me know.
#virology #cryoEM
go.bsky.app/Qxv95BL
#virology #cryoEM
go.bsky.app/Qxv95BL
November 25, 2025 at 9:46 AM
It’s been a while since I put together the Structural Virology starter pack, and I’m sure some new folks have joined Bluesky since then. There’s still plenty of space to fill, so if you’d like to be added to the list just let me know.
#virology #cryoEM
go.bsky.app/Qxv95BL
#virology #cryoEM
go.bsky.app/Qxv95BL
Reposted by Joost Snijder
📢 Paper alert 📢
Chirality is known to be important for the movement of microorganisms and active matter. In our new paper out today in @natphys.nature.com, we show that chirality is used by malaria parasites to control their motion patterns:
doi.org/10.1038/s415...
Here comes a 🧵 ... (1/9)
Chirality is known to be important for the movement of microorganisms and active matter. In our new paper out today in @natphys.nature.com, we show that chirality is used by malaria parasites to control their motion patterns:
doi.org/10.1038/s415...
Here comes a 🧵 ... (1/9)
November 24, 2025 at 5:50 PM
📢 Paper alert 📢
Chirality is known to be important for the movement of microorganisms and active matter. In our new paper out today in @natphys.nature.com, we show that chirality is used by malaria parasites to control their motion patterns:
doi.org/10.1038/s415...
Here comes a 🧵 ... (1/9)
Chirality is known to be important for the movement of microorganisms and active matter. In our new paper out today in @natphys.nature.com, we show that chirality is used by malaria parasites to control their motion patterns:
doi.org/10.1038/s415...
Here comes a 🧵 ... (1/9)
Reposted by Joost Snijder
Hello bsky 🦋 GlycoShape is now here to give you updates on our glycan 3D database, toolbox, glyco fun-facts and news!
We just updated server, so clear your browser's cache, and build some glycoproteins with us 🍬
We'll have great new tools coming up soon, so follow us for some exciting #glycotime
We just updated server, so clear your browser's cache, and build some glycoproteins with us 🍬
We'll have great new tools coming up soon, so follow us for some exciting #glycotime
a close up of a feather on a rock with the words `` hello '' written in white letters .
ALT: a close up of a feather on a rock with the words `` hello '' written in white letters .
media.tenor.com
November 24, 2025 at 4:50 PM
Hello bsky 🦋 GlycoShape is now here to give you updates on our glycan 3D database, toolbox, glyco fun-facts and news!
We just updated server, so clear your browser's cache, and build some glycoproteins with us 🍬
We'll have great new tools coming up soon, so follow us for some exciting #glycotime
We just updated server, so clear your browser's cache, and build some glycoproteins with us 🍬
We'll have great new tools coming up soon, so follow us for some exciting #glycotime
Reposted by Joost Snijder
Super happy to receive an M-2 weave grant from the NWO (Dutch Research Council). Together with Sayed Abd El-Whab we will study the molecular features of H5Nx HA and NA proteins. #glycotime www.nwo.nl/en/news/gran...
www.nwo.nl
November 24, 2025 at 9:42 AM
Super happy to receive an M-2 weave grant from the NWO (Dutch Research Council). Together with Sayed Abd El-Whab we will study the molecular features of H5Nx HA and NA proteins. #glycotime www.nwo.nl/en/news/gran...
Reposted by Joost Snijder
Wat betekent het voor ons als tech-miljardairs en cryptobedrijven de heerschappij van de banken zullen doorbreken? In zijn nieuwe boek ‘Geld genoeg, maar niet voor jou’ neemt Thomas Bollen je mee naar goudkluizen, banktorens en cryptofeestjes. www.ftm.nl/artikelen/ho...
Hoe heroveren we de macht over ons geld?
Van woningnood en groeiende ongelijkheid tot de opkomst van autocratische leiders – in zijn nieuwe boek ‘Geld genoeg, maar niet voor jou’ legt FTM-journalist Thomas Bollen bloot waarom de grote proble...
www.ftm.nl
September 20, 2025 at 6:31 AM
Wat betekent het voor ons als tech-miljardairs en cryptobedrijven de heerschappij van de banken zullen doorbreken? In zijn nieuwe boek ‘Geld genoeg, maar niet voor jou’ neemt Thomas Bollen je mee naar goudkluizen, banktorens en cryptofeestjes. www.ftm.nl/artikelen/ho...
Reposted by Joost Snijder
Structures of the fusion glycoprotein from respiratory syncytial virus (RSV) were used to engineer effective vaccines to fight viral infection
More at PDB-101:
More at PDB-101:
PDB101: Molecule of the Month: RSV Fusion Glycoprotein
Structures of the fusion glycoprotein from respiratory syncytial virus (RSV) were used to engineer effective vaccines to fight viral infection.
pdb101.rcsb.org
November 21, 2025 at 5:33 PM
Structures of the fusion glycoprotein from respiratory syncytial virus (RSV) were used to engineer effective vaccines to fight viral infection
More at PDB-101:
More at PDB-101:
Reposted by Joost Snijder
A BIG THANK YOU to everyone who joined us at the NVMS Fall Meeting 2025! 👏 Your energy and ideas made the meeting truly inspiring and a great fit for the House of Connections. ✨♥️ A recap will be online soon: www.nvms.nl Your NVMS board
#NVMS #MassSpectrometry #ScienceCommunity #DEI #Groningen
#NVMS #MassSpectrometry #ScienceCommunity #DEI #Groningen
NVMS
Nederlandse Vereniging voor Massaspectrometrie
www.nvms.nl
November 21, 2025 at 8:15 AM
A BIG THANK YOU to everyone who joined us at the NVMS Fall Meeting 2025! 👏 Your energy and ideas made the meeting truly inspiring and a great fit for the House of Connections. ✨♥️ A recap will be online soon: www.nvms.nl Your NVMS board
#NVMS #MassSpectrometry #ScienceCommunity #DEI #Groningen
#NVMS #MassSpectrometry #ScienceCommunity #DEI #Groningen
Reposted by Joost Snijder
The Brixen Summer School is back and is, as usual, building up a strong speaker list. Thank you @eupaproteomics.bsky.social @thermofishersci.bsky.social @biognosys.bsky.social @ionopticks.bsky.social @evosep.bsky.social for support!
November 21, 2025 at 9:54 AM
The Brixen Summer School is back and is, as usual, building up a strong speaker list. Thank you @eupaproteomics.bsky.social @thermofishersci.bsky.social @biognosys.bsky.social @ionopticks.bsky.social @evosep.bsky.social for support!
Reposted by Joost Snijder
Latest RFDiffusion3 from the Baker lab.
De novo Design of All-atom Biomolecular Interactions with RFdiffusion3
Deep learning has accelerated protein design, but most existing methods are restricted to generating protein backbone coordinates and often neglect interactions with other biomolecules. We present RFd...
www.biorxiv.org
November 20, 2025 at 10:32 PM
Latest RFDiffusion3 from the Baker lab.
Reposted by Joost Snijder
Excited to share a new publication from my PhD labs where we explore a method to improve antibody-mediated protection against herpes simplex virus infections: www.science.org/doi/10.1126/...
Eliminating interactions with the viral Fc receptor improves antibody-mediated protection against neonatal HSV infection in mice
HSV-specific antibodies demonstrate improved activity in vitro and in vivo when the IgG Fc domain is rendered insensitive to the viral Fc receptor.
www.science.org
November 19, 2025 at 7:04 PM
Excited to share a new publication from my PhD labs where we explore a method to improve antibody-mediated protection against herpes simplex virus infections: www.science.org/doi/10.1126/...
On my way to the @denvms.bsky.social fall meeting to present our antibody sequencing work 😁
November 19, 2025 at 8:39 AM
On my way to the @denvms.bsky.social fall meeting to present our antibody sequencing work 😁
Reposted by Joost Snijder
Not good at all
Ethiopia confirms outbreak of deadly Marburg virus
Africa CDC says at least nine cases have been detected of Ebola-like illness, which kills up to 80% of those infected
www.theguardian.com
November 16, 2025 at 8:21 AM
Not good at all
Reposted by Joost Snijder
The outbreak in Ethiopia is #Marburg virus, the first such outbreak for this country. 9 cases so far, including some health workers. x.com/drtedros/sta...
Tedros Adhanom Ghebreyesus on X: "#Ethiopia has confirmed the outbreak that has infected at least 9 people in the south of the country is of #Marburg virus disease. I commend Ethiopia’s @FMoHealth for its rapid and transparent response to the outbreak, and the work of the Ethiopia Public Health Institute and" / X
#Ethiopia has confirmed the outbreak that has infected at least 9 people in the south of the country is of #Marburg virus disease. I commend Ethiopia’s @FMoHealth for its rapid and transparent response to the outbreak, and the work of the Ethiopia Public Health Institute and
x.com
November 14, 2025 at 4:22 PM
The outbreak in Ethiopia is #Marburg virus, the first such outbreak for this country. 9 cases so far, including some health workers. x.com/drtedros/sta...
Reposted by Joost Snijder
MISO: microfluidic protein isolation enables single-particle cryo-EM structure determination from a single cell colony.
Or from a single dish of HEK cell culture in the case of two membrane proteins.
Out in Nature Methods now! lnkd.in/gpyBSceg
Wonderful collaboration with the Efremov lab.
Or from a single dish of HEK cell culture in the case of two membrane proteins.
Out in Nature Methods now! lnkd.in/gpyBSceg
Wonderful collaboration with the Efremov lab.
November 14, 2025 at 6:38 PM
MISO: microfluidic protein isolation enables single-particle cryo-EM structure determination from a single cell colony.
Or from a single dish of HEK cell culture in the case of two membrane proteins.
Out in Nature Methods now! lnkd.in/gpyBSceg
Wonderful collaboration with the Efremov lab.
Or from a single dish of HEK cell culture in the case of two membrane proteins.
Out in Nature Methods now! lnkd.in/gpyBSceg
Wonderful collaboration with the Efremov lab.
Reposted by Joost Snijder
On my way to Leiden for the annual ICI conference 😁
November 14, 2025 at 8:25 AM
On my way to Leiden for the annual ICI conference 😁
Reposted by Joost Snijder
Pleased to see this collaboration with a great PhD student Pei Cing Ng, from Prof. Luning Liu's lab at Liverpool University published. Structure of the H. neapolitanus carbonic anhydrase and localisation in a mini-carboxysome: www.pnas.org/doi/epdf/10....
November 13, 2025 at 9:57 AM
Pleased to see this collaboration with a great PhD student Pei Cing Ng, from Prof. Luning Liu's lab at Liverpool University published. Structure of the H. neapolitanus carbonic anhydrase and localisation in a mini-carboxysome: www.pnas.org/doi/epdf/10....
Reposted by Joost Snijder
Reposted by Joost Snijder
Our lab's paper describing the North American H5N1 epizootic is out now in Nature! So thrilled to have this out, and congratulations to @lambod50.bsky.social for all the fantastic work on this: www.nature.com/articles/s41...
Ecology and spread of the North American H5N1 epizootic - Nature
The panzootic of highly pathogenic H5N1 since 2021 was driven by around nine introductions into the Atlantic and Pacific flyways, followed by rapid dissemination through wild migratory birds, primaril...
www.nature.com
November 12, 2025 at 7:33 PM
Our lab's paper describing the North American H5N1 epizootic is out now in Nature! So thrilled to have this out, and congratulations to @lambod50.bsky.social for all the fantastic work on this: www.nature.com/articles/s41...