Dr Jolet Mimpen
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joletmimpen.bsky.social
Dr Jolet Mimpen
@joletmimpen.bsky.social
120 followers 92 following 12 posts
Arthritis UK Foundation Fellow at NDORMS, University of Oxford.

🇳🇱 living in 🇬🇧

Interested in osteoarthritis pathophysiology & tendon biology.
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joletmimpen.bsky.social
The transcriptomics analysis of our paper "Exploring cellular changes in ruptured human quadriceps tendons at single-cell resolution" suggests that fibroblasts and endothelial cells are key orchestrators of the early injury response within ruptured quadriceps tendon.
This Graphical abstract depicts healthy and acutely ruptured human quadriceps tendons. Using single nucleus RNA sequencing, the analysis shows that stromal cells change in ruptured quadriceps tendons, including increase of activated phenotype of fibroblasts, vascular endothelial cells, and macrophages, as well as increase in cell-cell interactions between fibroblasts and vascular endothelial cells.
July 21, 2025 at 4:55 PM