Jeremy Yap
@jeroptosis.bsky.social
PhD student at the Inflammasome Lab, the University of Queensland. Has a morbid fascination with death, specifically cell death 💀👻. Poster guy at @simbaatuq.bsky.social, newsletter guy @auscelldeathsoc.bsky.social.
Reposted by Jeremy Yap
The week of publications continues for the lab with a @currentbiology.bsky.social piece on ninj1 by @elliottbernard.bsky.social and @ehartenian.bsky.social check it out to have all your pressing ninj1 questions answered :)
www.cell.com/current-biol...
www.cell.com/current-biol...
November 21, 2025 at 9:12 PM
The week of publications continues for the lab with a @currentbiology.bsky.social piece on ninj1 by @elliottbernard.bsky.social and @ehartenian.bsky.social check it out to have all your pressing ninj1 questions answered :)
www.cell.com/current-biol...
www.cell.com/current-biol...
Reposted by Jeremy Yap
A few py2Dmol updates 🧬
py2dmol.solab.org
Integration with AlphaFoldDB (will auto fetch results). Drag and drop results from AF3-server or ColabFold for interactive experience! (1/4)
py2dmol.solab.org
Integration with AlphaFoldDB (will auto fetch results). Drag and drop results from AF3-server or ColabFold for interactive experience! (1/4)
November 19, 2025 at 8:15 AM
A few py2Dmol updates 🧬
py2dmol.solab.org
Integration with AlphaFoldDB (will auto fetch results). Drag and drop results from AF3-server or ColabFold for interactive experience! (1/4)
py2dmol.solab.org
Integration with AlphaFoldDB (will auto fetch results). Drag and drop results from AF3-server or ColabFold for interactive experience! (1/4)
Reposted by Jeremy Yap
NF-κB driven inflammation mediates loss of upper airway epithelial tolerance to Streptococcus pneumoniae during influenza co-infection https://www.biorxiv.org/content/10.1101/2025.10.25.684585v1
October 27, 2025 at 4:15 AM
NF-κB driven inflammation mediates loss of upper airway epithelial tolerance to Streptococcus pneumoniae during influenza co-infection https://www.biorxiv.org/content/10.1101/2025.10.25.684585v1
Reposted by Jeremy Yap
Blood cancer: reprogramming cell death to awaken immunity.
Institut Pasteur & Inserm scientists show that forcing malignant B cells into necroptosis triggers a powerful anti‑tumor response. A triple‑therapy strategy clears leukemia in preclinical models.
👉 www.pasteur.fr/en/press-are...
Institut Pasteur & Inserm scientists show that forcing malignant B cells into necroptosis triggers a powerful anti‑tumor response. A triple‑therapy strategy clears leukemia in preclinical models.
👉 www.pasteur.fr/en/press-are...
Blood cancer: a treatment to reprogram cancer cell death and trigger the immune system
The aim of immunotherapy strategies is to leverage cells in the patient's own immune system to destroy tumor cells. Using a preclinical model, scientists from the Institut Pasteur and Inserm successfu...
www.pasteur.fr
October 14, 2025 at 7:55 AM
Blood cancer: reprogramming cell death to awaken immunity.
Institut Pasteur & Inserm scientists show that forcing malignant B cells into necroptosis triggers a powerful anti‑tumor response. A triple‑therapy strategy clears leukemia in preclinical models.
👉 www.pasteur.fr/en/press-are...
Institut Pasteur & Inserm scientists show that forcing malignant B cells into necroptosis triggers a powerful anti‑tumor response. A triple‑therapy strategy clears leukemia in preclinical models.
👉 www.pasteur.fr/en/press-are...
Reposted by Jeremy Yap
Happy to share this review just out in Current Opinion in Immunology on innate immunity in the respiratory tract - also check out the other reviews in this collection on Intrinsic Immunity edited by John MacMicking #ImmunoSky #IDSky #pulmsky #MedSky www.sciencedirect.com/science/arti...
Layers of defense: protection from respiratory viruses by epithelial-intrinsic immunity
A central challenge in defending mucosal barriers is protecting against pathogens while also limiting excessive inflammation. Respiratory viruses are …
www.sciencedirect.com
October 13, 2025 at 3:26 PM
Happy to share this review just out in Current Opinion in Immunology on innate immunity in the respiratory tract - also check out the other reviews in this collection on Intrinsic Immunity edited by John MacMicking #ImmunoSky #IDSky #pulmsky #MedSky www.sciencedirect.com/science/arti...
Reposted by Jeremy Yap
Viral infections can wake up dormant breast cancer cells in the lung, driving metastasis
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Respiratory viral infections awaken metastatic breast cancer cells in lungs - Nature
Mouse models show that respiratory infections from viruses such as influenza and SARS-CoV-2 can trigger metastasis of dormant breast cancer cells in the lungs, a finding supported by epidemiological data from two large human cohorts.
www.nature.com
September 26, 2025 at 9:32 AM
Viral infections can wake up dormant breast cancer cells in the lung, driving metastasis
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Jeremy Yap
New #flowcytometery protocol drop from Oliver Burton.
This one is on optimising blocking while preserving signal, in particular how to overcome Fc interactions and dye-dye interactions, and preventing tandem break-down.
currentprotocols.onlinelibrary.wiley.com/doi/10.1002/...
This one is on optimising blocking while preserving signal, in particular how to overcome Fc interactions and dye-dye interactions, and preventing tandem break-down.
currentprotocols.onlinelibrary.wiley.com/doi/10.1002/...
Optimization of the Blocking and Signal Preservation Protocol in High‐Parameter Flow Cytometry
High quality input data is the key to successful interpretation of any scientific assay. In flow cytometry, fluorescently-conjugated antibodies allow us to simultaneously measure an incredible range ...
currentprotocols.onlinelibrary.wiley.com
September 25, 2025 at 5:06 PM
New #flowcytometery protocol drop from Oliver Burton.
This one is on optimising blocking while preserving signal, in particular how to overcome Fc interactions and dye-dye interactions, and preventing tandem break-down.
currentprotocols.onlinelibrary.wiley.com/doi/10.1002/...
This one is on optimising blocking while preserving signal, in particular how to overcome Fc interactions and dye-dye interactions, and preventing tandem break-down.
currentprotocols.onlinelibrary.wiley.com/doi/10.1002/...
Reposted by Jeremy Yap
#InterferonPower! Thrilled for our latest work @cp-cell.bsky.social! With @danielboehmer.bsky.social, we dug into tons of papers & created what we hope will be a go-to resource for immunologists & non-immunologist about type I, II, III (& IV😉) #interferons! Free👉 authors.elsevier.com/a/1leKGL7PXu...
August 21, 2025 at 3:20 PM
#InterferonPower! Thrilled for our latest work @cp-cell.bsky.social! With @danielboehmer.bsky.social, we dug into tons of papers & created what we hope will be a go-to resource for immunologists & non-immunologist about type I, II, III (& IV😉) #interferons! Free👉 authors.elsevier.com/a/1leKGL7PXu...
Reposted by Jeremy Yap
(1/3) 🚨 We’re back with Edition #2 of our 2025 International Cell Death Seminar Series! 🚨
📅 Wednesday 3 Sept | 🦘 4:30pm AEST / 🌍 8:30am CEST
In collaboration with @ecdoorg.bsky.social + @CDDpress.
Flyer below ⬇️
#ACDS #CellDeath
📅 Wednesday 3 Sept | 🦘 4:30pm AEST / 🌍 8:30am CEST
In collaboration with @ecdoorg.bsky.social + @CDDpress.
Flyer below ⬇️
#ACDS #CellDeath
August 18, 2025 at 3:54 AM
(1/3) 🚨 We’re back with Edition #2 of our 2025 International Cell Death Seminar Series! 🚨
📅 Wednesday 3 Sept | 🦘 4:30pm AEST / 🌍 8:30am CEST
In collaboration with @ecdoorg.bsky.social + @CDDpress.
Flyer below ⬇️
#ACDS #CellDeath
📅 Wednesday 3 Sept | 🦘 4:30pm AEST / 🌍 8:30am CEST
In collaboration with @ecdoorg.bsky.social + @CDDpress.
Flyer below ⬇️
#ACDS #CellDeath
Reposted by Jeremy Yap
SNAP-tag is a widespread tool for labelling protein for bioimaging. An article published in Nature Chemical Biology presents SNAP-tag2 with increased labelling kinetics and brightness, which translates into a better performance in live-cell super-resolution imaging. go.nature.com/46fMIZd 🧪
July 20, 2025 at 1:03 AM
SNAP-tag is a widespread tool for labelling protein for bioimaging. An article published in Nature Chemical Biology presents SNAP-tag2 with increased labelling kinetics and brightness, which translates into a better performance in live-cell super-resolution imaging. go.nature.com/46fMIZd 🧪
Reposted by Jeremy Yap
Congrats to @malvinapiz.bsky.social and @inflammasomelab.bsky.social on their new paper on the role of cardiolipin in non canonical inflammasome activation. We’re happy to have contributed to the story 🎉🦠!!
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
Cardiolipin inhibits the non-canonical inflammasome by preventing LPS binding to caspase-4/11 | The EMBO Journal
imageimageAvailable caspase-4/11 (CASP4/11) inhibitors also block the activity of caspase-1
(CASP1), which complicates interpretation of results in functional studies and limits
their clinical potenti...
www.embopress.org
July 19, 2025 at 11:18 AM
Congrats to @malvinapiz.bsky.social and @inflammasomelab.bsky.social on their new paper on the role of cardiolipin in non canonical inflammasome activation. We’re happy to have contributed to the story 🎉🦠!!
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
Reposted by Jeremy Yap
🚨 Applications for the 2025 ACDS Professional Development Award close soon!
Don't miss your chance to secure $2,000 for travel or training.
🗓️ Deadline: 5pm AEST, Friday 6 June
📩 Apply now: australasiancelldeathsociety.com/acds-awards
Don't miss your chance to secure $2,000 for travel or training.
🗓️ Deadline: 5pm AEST, Friday 6 June
📩 Apply now: australasiancelldeathsociety.com/acds-awards
(1/3) 🏆 Applications are now open for the 2025 ACDS Professional Development Award!
A $2,000 grant for a PhD student or ECR to support national or international professional development 🌍✈️
Conference? Lab visit? Data training? This one's for you.
More info below
A $2,000 grant for a PhD student or ECR to support national or international professional development 🌍✈️
Conference? Lab visit? Data training? This one's for you.
More info below
#celldeathresearch #careerdevelopment | Australasian Cell Death Society (ACDS)
🥇2025 ACDS Professional Development Award 🥇
Applications are now open!
Are you a PhD student or early-career researcher in the cell death field? Don’t miss your chance to apply for our $2,000 travel ...
www.linkedin.com
May 29, 2025 at 3:31 AM
🚨 Applications for the 2025 ACDS Professional Development Award close soon!
Don't miss your chance to secure $2,000 for travel or training.
🗓️ Deadline: 5pm AEST, Friday 6 June
📩 Apply now: australasiancelldeathsociety.com/acds-awards
Don't miss your chance to secure $2,000 for travel or training.
🗓️ Deadline: 5pm AEST, Friday 6 June
📩 Apply now: australasiancelldeathsociety.com/acds-awards
Reposted by Jeremy Yap
(1/3) 🏆 Applications are now open for the 2025 ACDS Professional Development Award!
A $2,000 grant for a PhD student or ECR to support national or international professional development 🌍✈️
Conference? Lab visit? Data training? This one's for you.
More info below
A $2,000 grant for a PhD student or ECR to support national or international professional development 🌍✈️
Conference? Lab visit? Data training? This one's for you.
More info below
#celldeathresearch #careerdevelopment | Australasian Cell Death Society (ACDS)
🥇2025 ACDS Professional Development Award 🥇
Applications are now open!
Are you a PhD student or early-career researcher in the cell death field? Don’t miss your chance to apply for our $2,000 travel ...
www.linkedin.com
May 5, 2025 at 1:01 AM
(1/3) 🏆 Applications are now open for the 2025 ACDS Professional Development Award!
A $2,000 grant for a PhD student or ECR to support national or international professional development 🌍✈️
Conference? Lab visit? Data training? This one's for you.
More info below
A $2,000 grant for a PhD student or ECR to support national or international professional development 🌍✈️
Conference? Lab visit? Data training? This one's for you.
More info below
Reposted by Jeremy Yap
Inflammatory signalling must eventually be turned off (e.g. by feedback inhibition) to prevent chronic inflammation. We didn't know how #inflammasomes turn off their signalling in vivo ... until now! (🧵: 1/3)
shorturl.at/8lWxW
shorturl.at/8lWxW
Caspase-1 self-terminates protease activity to enforce homeostasis and prevent inflammasome-driven diseases
Signal shutdown mechanisms must exist to silence the potent inflammatory programs initiated by the caspase-1 (CASP1) protease, to allow inflammation to resolve and reinstate tissue homeostasis. It is ...
shorturl.at
May 1, 2025 at 11:17 PM
Inflammatory signalling must eventually be turned off (e.g. by feedback inhibition) to prevent chronic inflammation. We didn't know how #inflammasomes turn off their signalling in vivo ... until now! (🧵: 1/3)
shorturl.at/8lWxW
shorturl.at/8lWxW
Reposted by Jeremy Yap
Quote of the day: “If you think research is expensive, try disease.” Mary Lasker
April 15, 2025 at 10:14 AM
Quote of the day: “If you think research is expensive, try disease.” Mary Lasker
Reposted by Jeremy Yap
This is how your email finds me #catsOfAcademia #AustralianMist
April 14, 2025 at 8:50 AM
This is how your email finds me #catsOfAcademia #AustralianMist
Reposted by Jeremy Yap
(1/3) 🌍 We're kicking off our 2025 International Cell Death Seminar Series with @ecdo & @CDDpress on Wed 7 May!
🕓 4:30pm AEST / 8:30am CEST
📍 Online (Zoom link in poster)
A fantastic international line-up awaits... 🧵👇
🕓 4:30pm AEST / 8:30am CEST
📍 Online (Zoom link in poster)
A fantastic international line-up awaits... 🧵👇
April 8, 2025 at 5:55 AM
(1/3) 🌍 We're kicking off our 2025 International Cell Death Seminar Series with @ecdo & @CDDpress on Wed 7 May!
🕓 4:30pm AEST / 8:30am CEST
📍 Online (Zoom link in poster)
A fantastic international line-up awaits... 🧵👇
🕓 4:30pm AEST / 8:30am CEST
📍 Online (Zoom link in poster)
A fantastic international line-up awaits... 🧵👇
Congrats @michelleyeaphw.bsky.social 🥳🙌
I am excited to share that Michelle's (Hui Wen) PhD work on microbial subversion of innate immune and cell death pathways is now online! Congrats @michelleyeaphw.bsky.social and all co-authors! 🥳
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
A bacterial network of T3SS effectors counteracts host pro-inflammatory responses and cell death to promote infection | The EMBO Journal
imageimageHost cells activate cell death pathways in response to bacterial manipulation of innate
immune signalling, but the molecular mechanisms underlying this interplay are not
fully understood. Th...
www.embopress.org
March 25, 2025 at 2:44 AM
Congrats @michelleyeaphw.bsky.social 🥳🙌
Reposted by Jeremy Yap
So THAT'S what Granzyme K does-- cleave complement and promote inflammation in the airway. Fascinating!
#ImmunoSky #AsthmaSky
#InflammationSky
www.nature.com/articles/s41...
#ImmunoSky #AsthmaSky
#InflammationSky
www.nature.com/articles/s41...
GZMK-expressing CD8+ T cells promote recurrent airway inflammatory diseases - Nature
Comparing T cells in nasal polyps from repeated surgeries shows that effector memory-like persistent clones colonize the mucosal tissue during disease recurrence and promote inflammation by producing ...
www.nature.com
February 13, 2025 at 6:54 PM
So THAT'S what Granzyme K does-- cleave complement and promote inflammation in the airway. Fascinating!
#ImmunoSky #AsthmaSky
#InflammationSky
www.nature.com/articles/s41...
#ImmunoSky #AsthmaSky
#InflammationSky
www.nature.com/articles/s41...
Reposted by Jeremy Yap
Reposted by Jeremy Yap
Gasdermin D mediates a fast transient release of ATP after NLRP3 inflammasome activation before ninjurin 1-induced lytic cell death
www.cell.com/cell-reports...
@cp-cellreports.bsky.social @pablopelegrini.bsky.social
www.cell.com/cell-reports...
@cp-cellreports.bsky.social @pablopelegrini.bsky.social
January 31, 2025 at 6:31 PM
Gasdermin D mediates a fast transient release of ATP after NLRP3 inflammasome activation before ninjurin 1-induced lytic cell death
www.cell.com/cell-reports...
@cp-cellreports.bsky.social @pablopelegrini.bsky.social
www.cell.com/cell-reports...
@cp-cellreports.bsky.social @pablopelegrini.bsky.social
Reposted by Jeremy Yap
Our paper out @Nature: CARD domains mediate anti-phage defense in bacterial gasdermin systems
CARDs are essential for caspase recruitment during human inflammasome activation. We now find them in bacterial immune systems
Congrats Tana Wein! Thank you Kranzusch lab!
www.nature.com/articles/s41...
CARDs are essential for caspase recruitment during human inflammasome activation. We now find them in bacterial immune systems
Congrats Tana Wein! Thank you Kranzusch lab!
www.nature.com/articles/s41...
January 30, 2025 at 3:40 AM
Our paper out @Nature: CARD domains mediate anti-phage defense in bacterial gasdermin systems
CARDs are essential for caspase recruitment during human inflammasome activation. We now find them in bacterial immune systems
Congrats Tana Wein! Thank you Kranzusch lab!
www.nature.com/articles/s41...
CARDs are essential for caspase recruitment during human inflammasome activation. We now find them in bacterial immune systems
Congrats Tana Wein! Thank you Kranzusch lab!
www.nature.com/articles/s41...
Reposted by Jeremy Yap
Innate immune memory is stimulus specific
@arjunraj.bsky.social @aofarrell.bsky.social
doi.org/10.1101/2025...
@arjunraj.bsky.social @aofarrell.bsky.social
doi.org/10.1101/2025...
January 27, 2025 at 3:18 AM
Innate immune memory is stimulus specific
@arjunraj.bsky.social @aofarrell.bsky.social
doi.org/10.1101/2025...
@arjunraj.bsky.social @aofarrell.bsky.social
doi.org/10.1101/2025...
Reposted by Jeremy Yap
Thrilled to start 2025 with our latest findings! Yersinia invades macrophage cytosol to activate caspase-11 when caspase-8 or YopJ are inactive. www.cell.com/cell-reports...
Plasticity of cell death pathways ensures GSDMD activation during Yersinia pseudotuberculosis infection
Injection of YopJ by Yersinia pseudotuberculosis triggers RIPK1-dependent caspase-8
and GSDMD activation in murine macrophages; however, how macrophages defend against
Yersinia when caspase-8 or YopJ ...
www.cell.com
January 16, 2025 at 11:09 PM
Thrilled to start 2025 with our latest findings! Yersinia invades macrophage cytosol to activate caspase-11 when caspase-8 or YopJ are inactive. www.cell.com/cell-reports...
Mitochondria are suicide pills of the cell.
☕This year, in our #CellDeath focus:
Glover, Schreiner, Dewson & Tait reviewed the intersection of #mitochondria and cell death. #pyroptosis #ferroptosis #necroptosis #apoptosis
👉https://rdcu.be/d46gt
www.nature.com/articles/s41...
Glover, Schreiner, Dewson & Tait reviewed the intersection of #mitochondria and cell death. #pyroptosis #ferroptosis #necroptosis #apoptosis
👉https://rdcu.be/d46gt
www.nature.com/articles/s41...
Mitochondria and cell death - Nature Cell Biology
Several processes of regulated cell death engage or use mitochondria, which are thus central hubs that not only coordinate cell death but also elicit non-lethal signalling mediated by mitochondrial ou...
www.nature.com
January 15, 2025 at 1:31 PM
Mitochondria are suicide pills of the cell.