Jeroen Van Schependom
@jeroenvs.bsky.social
Associate Professor NeuroEngineering, interested in brain dynamics, neuromodulation and cognitive impairment in multiple sclerosis
@vub_etro, @AIMS_VUB, @VUBrussel, Member @JongeAcademie
@vub_etro, @AIMS_VUB, @VUBrussel, Member @JongeAcademie
Fahimeh built upon her previous work on the spectral slope as a marker of E/I balance in MS during rest: onlinelibrary.wiley.com/doi/10.1002/... and its modulation during a working memory paradigm: journals.sagepub.com/doi/10.1177/...
The spectral slope as a marker of excitation/inhibition ratio and cognitive functioning in multiple sclerosis
The 1/f slope enables us to pick up the inhibitory effect of benzodiazepines in people with multiple sclerosis (pwMS). Cognitively impaired pwMS also demonstrate a steeper 1/f slope, suggesting a dec...
onlinelibrary.wiley.com
November 7, 2025 at 2:15 PM
Fahimeh built upon her previous work on the spectral slope as a marker of E/I balance in MS during rest: onlinelibrary.wiley.com/doi/10.1002/... and its modulation during a working memory paradigm: journals.sagepub.com/doi/10.1177/...
Conclusion:
Dichotomization has its place in clinical decision-making, but for research, let’s keep the richness of the data intact. It’s a smarter path to sensitive, specific, and mechanistically meaningful cognitive biomarkers.
Dichotomization has its place in clinical decision-making, but for research, let’s keep the richness of the data intact. It’s a smarter path to sensitive, specific, and mechanistically meaningful cognitive biomarkers.
August 13, 2025 at 6:54 AM
Conclusion:
Dichotomization has its place in clinical decision-making, but for research, let’s keep the richness of the data intact. It’s a smarter path to sensitive, specific, and mechanistically meaningful cognitive biomarkers.
Dichotomization has its place in clinical decision-making, but for research, let’s keep the richness of the data intact. It’s a smarter path to sensitive, specific, and mechanistically meaningful cognitive biomarkers.
Rich, domain-focused continuous measures can better detect treatment effects, map brain–cognition links & guide targeted rehab—especially with small MS study cohorts.
August 13, 2025 at 6:54 AM
Rich, domain-focused continuous measures can better detect treatment effects, map brain–cognition links & guide targeted rehab—especially with small MS study cohorts.
Key points:
• Continuous scores catch subtle effects
• Domain-specific analysis reveals unique deficits & neural links
• Collapsing across domains masks key patterns
• Continuous scores catch subtle effects
• Domain-specific analysis reveals unique deficits & neural links
• Collapsing across domains masks key patterns
August 13, 2025 at 6:54 AM
Key points:
• Continuous scores catch subtle effects
• Domain-specific analysis reveals unique deficits & neural links
• Collapsing across domains masks key patterns
• Continuous scores catch subtle effects
• Domain-specific analysis reveals unique deficits & neural links
• Collapsing across domains masks key patterns
In our simulations (N=50, r=0.3), continuous analysis had 28.1% power vs 15.7% after dichotomizing—a ~44% loss. This can obscure real effects & waste precious sample size in MS research.
August 13, 2025 at 6:54 AM
In our simulations (N=50, r=0.3), continuous analysis had 28.1% power vs 15.7% after dichotomizing—a ~44% loss. This can obscure real effects & waste precious sample size in MS research.
Read more: www.jmir.org/2025/1/e53503
Congrats to Stijn Denissen! 🙌
#MultipleSclerosis #DigitalHealth #CognitiveScreening
Congrats to Stijn Denissen! 🙌
#MultipleSclerosis #DigitalHealth #CognitiveScreening
A New Smartphone-Based Cognitive Screening Battery for Multiple Sclerosis (icognition): Validation Study
Background: Cognitive deterioration is common in multiple sclerosis (MS) and requires regular follow-up. Currently, cognitive status is measured in clinical practice using paper-and-pencil tests, whic...
www.jmir.org
January 21, 2025 at 7:34 AM
Read more: www.jmir.org/2025/1/e53503
Congrats to Stijn Denissen! 🙌
#MultipleSclerosis #DigitalHealth #CognitiveScreening
Congrats to Stijn Denissen! 🙌
#MultipleSclerosis #DigitalHealth #CognitiveScreening
4️⃣ What’s next?
We're integrating icognition into a digital health platform with brain imaging & patient-reported outcomes. This could revolutionize MS care by enabling remote cognitive monitoring!
We're integrating icognition into a digital health platform with brain imaging & patient-reported outcomes. This could revolutionize MS care by enabling remote cognitive monitoring!
January 21, 2025 at 7:34 AM
4️⃣ What’s next?
We're integrating icognition into a digital health platform with brain imaging & patient-reported outcomes. This could revolutionize MS care by enabling remote cognitive monitoring!
We're integrating icognition into a digital health platform with brain imaging & patient-reported outcomes. This could revolutionize MS care by enabling remote cognitive monitoring!
3️⃣ What did we find?
✅ icognition correlates well with paper-and-pencil equivalents
✅ It’s reliable (good test-retest stats)
✅ Shows potential for real-world use in MS
✅ icognition correlates well with paper-and-pencil equivalents
✅ It’s reliable (good test-retest stats)
✅ Shows potential for real-world use in MS
January 21, 2025 at 7:34 AM
3️⃣ What did we find?
✅ icognition correlates well with paper-and-pencil equivalents
✅ It’s reliable (good test-retest stats)
✅ Shows potential for real-world use in MS
✅ icognition correlates well with paper-and-pencil equivalents
✅ It’s reliable (good test-retest stats)
✅ Shows potential for real-world use in MS
2️⃣ What's icognition?
We developed a smartphone-based screening battery with 3 tests:
Symbol Test: Info processing speed
Dot Test: Visuospatial memory
vBDS: Working memory
Each is based on validated gold-standard tests but adapted for remote use.
We developed a smartphone-based screening battery with 3 tests:
Symbol Test: Info processing speed
Dot Test: Visuospatial memory
vBDS: Working memory
Each is based on validated gold-standard tests but adapted for remote use.
January 21, 2025 at 7:34 AM
2️⃣ What's icognition?
We developed a smartphone-based screening battery with 3 tests:
Symbol Test: Info processing speed
Dot Test: Visuospatial memory
vBDS: Working memory
Each is based on validated gold-standard tests but adapted for remote use.
We developed a smartphone-based screening battery with 3 tests:
Symbol Test: Info processing speed
Dot Test: Visuospatial memory
vBDS: Working memory
Each is based on validated gold-standard tests but adapted for remote use.
1️⃣ Why does this matter?
Cognitive decline is common in MS but often difficult to track due to reliance on traditional paper-and-pencil tests. These are time-intensive, costly, and not easily accessible. Remote monitoring could change this!
Cognitive decline is common in MS but often difficult to track due to reliance on traditional paper-and-pencil tests. These are time-intensive, costly, and not easily accessible. Remote monitoring could change this!
January 21, 2025 at 7:34 AM
1️⃣ Why does this matter?
Cognitive decline is common in MS but often difficult to track due to reliance on traditional paper-and-pencil tests. These are time-intensive, costly, and not easily accessible. Remote monitoring could change this!
Cognitive decline is common in MS but often difficult to track due to reliance on traditional paper-and-pencil tests. These are time-intensive, costly, and not easily accessible. Remote monitoring could change this!