Jake Watson
@jakefwatson.bsky.social
Neurophysiologist @ ISTAustria
Synapses, microcircuits, hippocampus.
Google Scholar: https://bit.ly/jakefwatson
Research summary: www.synapticarrangements.org
Synapses, microcircuits, hippocampus.
Google Scholar: https://bit.ly/jakefwatson
Research summary: www.synapticarrangements.org
And you'll find the preprint explainer here:
Recording synaptic minis (mEPSCs)? We have a new paper trying to better understand how recorded datasets match synaptic changes. In short, they don't..
More info below, and the preprint here:
biorxiv.org/content/10.1101/2024.10.26.620084v1
More info below, and the preprint here:
biorxiv.org/content/10.1101/2024.10.26.620084v1
September 29, 2025 at 11:54 AM
And you'll find the preprint explainer here:
Hi Pablo - if you still need the info, this pattern is very nice staining of the mossy fibre tract (DG output). Your protein seems to be specific for granule cell axons!
August 4, 2025 at 12:24 PM
Hi Pablo - if you still need the info, this pattern is very nice staining of the mossy fibre tract (DG output). Your protein seems to be specific for granule cell axons!
Glad you enjoyed it John!
August 3, 2025 at 11:17 AM
Glad you enjoyed it John!
There is a lot more on cell and synaptic properties in the full paper, but this data adds to the emerging picture of heterogeneous excitatory neurons... many interesting cell and circuit features can be revealed only by diving into the (often complex and confusing) heterogeneity of the brain!
August 2, 2025 at 2:25 PM
There is a lot more on cell and synaptic properties in the full paper, but this data adds to the emerging picture of heterogeneous excitatory neurons... many interesting cell and circuit features can be revealed only by diving into the (often complex and confusing) heterogeneity of the brain!
Inhibitory wiring also had a surprise. Spontaneous GABAergic input was strikingly coincident on PNs of the same subclass, suggesting specific wiring of interneurons into each PN type - for layer-specific control! @zhihaozheng.bsky.social has now visualized this wiring in his beautiful connectomics
August 2, 2025 at 2:25 PM
Inhibitory wiring also had a surprise. Spontaneous GABAergic input was strikingly coincident on PNs of the same subclass, suggesting specific wiring of interneurons into each PN type - for layer-specific control! @zhihaozheng.bsky.social has now visualized this wiring in his beautiful connectomics
Deep and superficial PNs had a surprise in their recurrent connectivity: superficial PNs connect broadly, but deep PNs show little local connectivity back to superficial cells. This suggests that deep PNs form their own subnetwork, perhaps 'associating the associations' made in superficial CA3..
August 2, 2025 at 2:25 PM
Deep and superficial PNs had a surprise in their recurrent connectivity: superficial PNs connect broadly, but deep PNs show little local connectivity back to superficial cells. This suggests that deep PNs form their own subnetwork, perhaps 'associating the associations' made in superficial CA3..
Across the brain, PNs show a lot of heterogeneity. In CA3 it’s clearest on the deep-superficial axis, and we see 'deep bursting' PNs that have been shown before. From hundreds of recorded cells, these are clearly a distinct subclass in our hands, but are not strictly 'athorny' as has been suggested.
August 2, 2025 at 2:25 PM
Across the brain, PNs show a lot of heterogeneity. In CA3 it’s clearest on the deep-superficial axis, and we see 'deep bursting' PNs that have been shown before. From hundreds of recorded cells, these are clearly a distinct subclass in our hands, but are not strictly 'athorny' as has been suggested.
This may help, depending on your chosen ally: ivaprime.com
IVA Prime
ivaprime.com
July 20, 2025 at 4:06 PM
This may help, depending on your chosen ally: ivaprime.com
..and it is not every meeting that your first task for the day is trying to keep up with Brazilian football on the beach!
We are on for #Day4 at the #Neural Mechanisms of #cognitive Function at Pipa, Brazil 🇧🇷
Respecting local tradition the first session was ⚽️ 🏖️🏆🥇
Great to play with @melgaby.bsky.social after 8 years! (of course he’s as competitive as ever 😅)
@jakefwatson.bsky.social @tristan-geiller.bsky.social ⭐️
Respecting local tradition the first session was ⚽️ 🏖️🏆🥇
Great to play with @melgaby.bsky.social after 8 years! (of course he’s as competitive as ever 😅)
@jakefwatson.bsky.social @tristan-geiller.bsky.social ⭐️
April 16, 2025 at 2:22 PM
..and it is not every meeting that your first task for the day is trying to keep up with Brazilian football on the beach!
A heartfelt thanks to all the organisers for bringing together a fantastic community of students and speakers for an incredibly inspiring meeting!
@vitorlds.bsky.social
@rhythmicspikes.bsky.social
Andressa Radiske
& Caro Gonzalez
@vitorlds.bsky.social
@rhythmicspikes.bsky.social
Andressa Radiske
& Caro Gonzalez
April 16, 2025 at 2:22 PM
A heartfelt thanks to all the organisers for bringing together a fantastic community of students and speakers for an incredibly inspiring meeting!
@vitorlds.bsky.social
@rhythmicspikes.bsky.social
Andressa Radiske
& Caro Gonzalez
@vitorlds.bsky.social
@rhythmicspikes.bsky.social
Andressa Radiske
& Caro Gonzalez
And finally talk 20 was @rhythmicspikes.bsky.social herself presenting beautiful data asking really insightful questions on how brain activity is linked to location and movement during memory tasks!
April 14, 2025 at 7:57 PM
And finally talk 20 was @rhythmicspikes.bsky.social herself presenting beautiful data asking really insightful questions on how brain activity is linked to location and movement during memory tasks!