htw
@heniek-htw.bsky.social
Look deep, patiently into nature & then you will understand everything better.
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htw
@heniek-htw.bsky.social
· Nov 14
Broken circadian clock: The emerging neuro-immune link connecting depression to cancer
This review systemically describes the fundamental mechanisms of #circadian clocks and the interacting relationships among broken circadian clock, #cancer & #depression.
👇
www.sciencedirect.com/science/arti...
This review systemically describes the fundamental mechanisms of #circadian clocks and the interacting relationships among broken circadian clock, #cancer & #depression.
👇
www.sciencedirect.com/science/arti...
•Reviews how mitochondrial protein import maintains cellular and organelle homeostasis.
•Summarizes the main stress response pathways (ISR, UPRam, UPRmt, mitophagy) triggered by import dysfunction.
www.sciencedirect.com/science/arti...
•Summarizes the main stress response pathways (ISR, UPRam, UPRmt, mitophagy) triggered by import dysfunction.
www.sciencedirect.com/science/arti...
December 5, 2025 at 9:40 AM
•Reviews how mitochondrial protein import maintains cellular and organelle homeostasis.
•Summarizes the main stress response pathways (ISR, UPRam, UPRmt, mitophagy) triggered by import dysfunction.
www.sciencedirect.com/science/arti...
•Summarizes the main stress response pathways (ISR, UPRam, UPRmt, mitophagy) triggered by import dysfunction.
www.sciencedirect.com/science/arti...
This review integrates evidence from preclinical and clinical studies to explain how tryptophan catabolism interacts with microbial activity and steroid regulation.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
December 5, 2025 at 9:35 AM
This review integrates evidence from preclinical and clinical studies to explain how tryptophan catabolism interacts with microbial activity and steroid regulation.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Effects of exercise on the intercellular communications, inflammation, and gut microbiome.
December 4, 2025 at 6:17 PM
Effects of exercise on the intercellular communications, inflammation, and gut microbiome.
Exercise attenuates the hallmarks of aging: Novel perspectives
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
December 4, 2025 at 6:16 PM
Exercise attenuates the hallmarks of aging: Novel perspectives
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Reposted by htw
The 3D arrangement of DNA within a cell might influence the ability of a tumour to metastasise to specific locations.
buff.ly/KbO9jwD
buff.ly/KbO9jwD
When cancer adapts to new organs
The three-dimensional arrangement of DNA within a cell might influence the ability of a tumor to metastasize to specific locations.
buff.ly
December 4, 2025 at 2:44 PM
The 3D arrangement of DNA within a cell might influence the ability of a tumour to metastasise to specific locations.
buff.ly/KbO9jwD
buff.ly/KbO9jwD
Cinnamaldehyde suppresses ovarian cancer progression by activating ROS-mediated apoptosis and mitophagy
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
December 4, 2025 at 11:54 AM
Cinnamaldehyde suppresses ovarian cancer progression by activating ROS-mediated apoptosis and mitophagy
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Reposted by htw
Excessive vigorous exercise impairs cognitive function through a muscle-derived mitochondrial pretender: Cell Metabolism www.cell.com/cell-metabol...
Excessive vigorous exercise impairs cognitive function through a muscle-derived mitochondrial pretender
Huang et al. show that excessive vigorous exercise causes cognitive impairment. During
this process, muscle lactate accumulation facilitates the secretion of otMDVs through
ATF5 lactylation. PAF and m...
www.cell.com
December 4, 2025 at 10:04 AM
Excessive vigorous exercise impairs cognitive function through a muscle-derived mitochondrial pretender: Cell Metabolism www.cell.com/cell-metabol...
Reposted by htw
The fun leaving your body the moment you're done with the science and it's time to get it published
December 4, 2025 at 11:15 AM
The fun leaving your body the moment you're done with the science and it's time to get it published
Fish skin has independent "visual" system
Red light → activates Rho → melanin suppression→skin lightening
Blue light → activates Opn4al2 → melanin synthesis → skin darkening
Melanocyte opsins function as light-triggered pigment switches for eye-independent color adaptation
Red light → activates Rho → melanin suppression→skin lightening
Blue light → activates Opn4al2 → melanin synthesis → skin darkening
Melanocyte opsins function as light-triggered pigment switches for eye-independent color adaptation
Dual photoreception via rho and opn4al2 drives light-dependent color plasticity in Plectropomus leopardus
Body coloration in fish is crucial for ecological adaptation and commercial value, regulated by opsin-based photoreception in response to ambient ligh…
www.sciencedirect.com
December 4, 2025 at 10:48 AM
Fish skin has independent "visual" system
Red light → activates Rho → melanin suppression→skin lightening
Blue light → activates Opn4al2 → melanin synthesis → skin darkening
Melanocyte opsins function as light-triggered pigment switches for eye-independent color adaptation
Red light → activates Rho → melanin suppression→skin lightening
Blue light → activates Opn4al2 → melanin synthesis → skin darkening
Melanocyte opsins function as light-triggered pigment switches for eye-independent color adaptation
• Higher daily steps link to better #sleep quality, shorter sleep duration, and reduced daytime dysfunction
• Step-increasing interventions improve sleep duration and reduce sleep disturbances
• No consistent step-sleep relationships were found for sleep latency or sleep efficiency
• Step-increasing interventions improve sleep duration and reduce sleep disturbances
• No consistent step-sleep relationships were found for sleep latency or sleep efficiency
Daily steps and sleep in adults: A systematic review and meta-analysis
Sleep problems constitute a global public health challenge, imposing adverse health consequences and substantial economic costs. Although physical act…
www.sciencedirect.com
December 4, 2025 at 10:09 AM
• Higher daily steps link to better #sleep quality, shorter sleep duration, and reduced daytime dysfunction
• Step-increasing interventions improve sleep duration and reduce sleep disturbances
• No consistent step-sleep relationships were found for sleep latency or sleep efficiency
• Step-increasing interventions improve sleep duration and reduce sleep disturbances
• No consistent step-sleep relationships were found for sleep latency or sleep efficiency
• This study found that nighttime hospital arrival was associated with higher in-hospital mortality in pediatric patients with severe trauma.
• Establishing medical systems that deliver continuous, high-quality care is essential for reducing mortality in this patient population.
• Establishing medical systems that deliver continuous, high-quality care is essential for reducing mortality in this patient population.
Association between hospital arrival time/day and mortality in pediatric patients with severe trauma: a nationwide retrospective observational study in Japan
This study aimed to evaluate the association between hospital arrival time/day and mortality in pediatric patients with severe trauma.This retrospecti…
www.sciencedirect.com
December 4, 2025 at 9:36 AM
• This study found that nighttime hospital arrival was associated with higher in-hospital mortality in pediatric patients with severe trauma.
• Establishing medical systems that deliver continuous, high-quality care is essential for reducing mortality in this patient population.
• Establishing medical systems that deliver continuous, high-quality care is essential for reducing mortality in this patient population.
Circadian clocks and adaptive immune function: from mechanisms to therapeutic applications
www.frontiersin.org/journals/imm...
www.frontiersin.org/journals/imm...
December 4, 2025 at 9:01 AM
Circadian clocks and adaptive immune function: from mechanisms to therapeutic applications
www.frontiersin.org/journals/imm...
www.frontiersin.org/journals/imm...
•NIR improves cognitive function in aged POCD mice by reducing hippocampal and neuronal ferroptosis.
•Lcn2 regulates ferroptosis and is a promising target for alleviating POCD.
•NIR suppresses Lcn2 to mitigate hippocampal neuronal ferroptosis in POCD.
•Lcn2 regulates ferroptosis and is a promising target for alleviating POCD.
•NIR suppresses Lcn2 to mitigate hippocampal neuronal ferroptosis in POCD.
Near-infrared light improves postoperative cognitive dysfunction by alleviating Lcn2-dependent ferroptosis induced neuronal injury
Iron overload and oxidative stress significantly contribute to the pathophysiology of postoperative cognitive dysfunction (POCD). Our previous finding…
www.sciencedirect.com
December 2, 2025 at 7:19 AM
•NIR improves cognitive function in aged POCD mice by reducing hippocampal and neuronal ferroptosis.
•Lcn2 regulates ferroptosis and is a promising target for alleviating POCD.
•NIR suppresses Lcn2 to mitigate hippocampal neuronal ferroptosis in POCD.
•Lcn2 regulates ferroptosis and is a promising target for alleviating POCD.
•NIR suppresses Lcn2 to mitigate hippocampal neuronal ferroptosis in POCD.
Cancer, deuterium, and gut microbes: A novel perspective
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
December 1, 2025 at 6:17 PM
Cancer, deuterium, and gut microbes: A novel perspective
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
The real-world data analysis suggests that integrating deuterium depletion via DDW into standard cancer treatments could multiply survival probability by a factor of 4–5 and lower cancer-specific mortality rates by approximately 75–80%."
Real-World Data Confirm That the Integration of Deuterium Depletion into Conventional Cancer Therapy Multiplies the Survival Probability of Patients
Background: Over thirty years of basic research has demonstrated that the deuterium-to-hydrogen ratio plays a pivotal role in regulating metabolism and cell growth via a sub-molecular regulatory system that orchestrates the intricate complexity of ...
pmc.ncbi.nlm.nih.gov
December 1, 2025 at 6:14 PM
The real-world data analysis suggests that integrating deuterium depletion via DDW into standard cancer treatments could multiply survival probability by a factor of 4–5 and lower cancer-specific mortality rates by approximately 75–80%."
Immune Dysregulation and Neuroinflammation in Bipolar Disorder: Pathophysiological Insights and Therapeutic Perspectives
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
December 1, 2025 at 4:44 PM
Immune Dysregulation and Neuroinflammation in Bipolar Disorder: Pathophysiological Insights and Therapeutic Perspectives
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
This study offers a comprehensive overview of current developments in EV research for the main autoimmune conditions, including inflammatory bowel disease, systemic lupus erythematosus, and rheumatoid arthritis.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
December 1, 2025 at 7:32 AM
This study offers a comprehensive overview of current developments in EV research for the main autoimmune conditions, including inflammatory bowel disease, systemic lupus erythematosus, and rheumatoid arthritis.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
•Vitamin C combined with PD-1 blockade alleviates lymphopenia during BVDV infection
•Vitamin C downregulated PD-1 expression in CD4+ T-cell of BVDV-infected mice
•Vitamin C enhanced CD4+ T-cell antiviral immunity during NCP BVDV infection
•Vitamin C downregulated PD-1 expression in CD4+ T-cell of BVDV-infected mice
•Vitamin C enhanced CD4+ T-cell antiviral immunity during NCP BVDV infection
Vitamin C combined with anti-PD-1 antibody alleviates peripheral lymphopenia and enhances CD4+ T-cell antiviral immunity during BVDV infection
Bovine viral diarrhea virus (BVDV)-induced lymphopenia is associated with immune dysfunction. Vitamin C (VC) improves immune response by increasing pe…
www.sciencedirect.com
December 1, 2025 at 7:28 AM
•Vitamin C combined with PD-1 blockade alleviates lymphopenia during BVDV infection
•Vitamin C downregulated PD-1 expression in CD4+ T-cell of BVDV-infected mice
•Vitamin C enhanced CD4+ T-cell antiviral immunity during NCP BVDV infection
•Vitamin C downregulated PD-1 expression in CD4+ T-cell of BVDV-infected mice
•Vitamin C enhanced CD4+ T-cell antiviral immunity during NCP BVDV infection
Reposted by htw
30 November 1898 | A Polish woman, Łucja Smerańska, was born in Stary Sącz. A teacher.
In #Auschwitz from 29 January 1943.
No. 32442
She perished in the camp on 12 March 1943.
---
Women at Auschwitz
Lesson: https://lekcja.auschwitz.org/2022_kobiety_en/
Podcast: https://youtu.be/ijTxtbNlJO8
In #Auschwitz from 29 January 1943.
No. 32442
She perished in the camp on 12 March 1943.
---
Women at Auschwitz
Lesson: https://lekcja.auschwitz.org/2022_kobiety_en/
Podcast: https://youtu.be/ijTxtbNlJO8
November 30, 2025 at 6:00 PM
30 November 1898 | A Polish woman, Łucja Smerańska, was born in Stary Sącz. A teacher.
In #Auschwitz from 29 January 1943.
No. 32442
She perished in the camp on 12 March 1943.
---
Women at Auschwitz
Lesson: https://lekcja.auschwitz.org/2022_kobiety_en/
Podcast: https://youtu.be/ijTxtbNlJO8
In #Auschwitz from 29 January 1943.
No. 32442
She perished in the camp on 12 March 1943.
---
Women at Auschwitz
Lesson: https://lekcja.auschwitz.org/2022_kobiety_en/
Podcast: https://youtu.be/ijTxtbNlJO8
The impact of gut-liver-derived mediators on the organ crosstalk with brain, heart, and kidney: a systematic review
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
November 30, 2025 at 4:30 PM
The impact of gut-liver-derived mediators on the organ crosstalk with brain, heart, and kidney: a systematic review
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
In this study, we demonstrated that imeglimin alters peripheral clock gene expression in healthy mice under both acute bolus administration and chronic mixed-feeding conditions.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
November 30, 2025 at 1:48 PM
In this study, we demonstrated that imeglimin alters peripheral clock gene expression in healthy mice under both acute bolus administration and chronic mixed-feeding conditions.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
• Unhealthy #sleep pattern alone: 75% higher risk of #schizophrenia (HR=1.75)
• High genetic risk (PRS) alone: 268% higher risk (HR=3.68)
• Combination of unhealthy sleep and high genetic risk: 480% higher risk (HR=5.80) compared to those with a healthy sleep pattern and low genetic risk.
• High genetic risk (PRS) alone: 268% higher risk (HR=3.68)
• Combination of unhealthy sleep and high genetic risk: 480% higher risk (HR=5.80) compared to those with a healthy sleep pattern and low genetic risk.
November 30, 2025 at 12:35 PM
• Unhealthy #sleep pattern alone: 75% higher risk of #schizophrenia (HR=1.75)
• High genetic risk (PRS) alone: 268% higher risk (HR=3.68)
• Combination of unhealthy sleep and high genetic risk: 480% higher risk (HR=5.80) compared to those with a healthy sleep pattern and low genetic risk.
• High genetic risk (PRS) alone: 268% higher risk (HR=3.68)
• Combination of unhealthy sleep and high genetic risk: 480% higher risk (HR=5.80) compared to those with a healthy sleep pattern and low genetic risk.
The PER2:BRCA1:POU2F1(OCT-1) Ternary Complex Represents a Multi-Component Scaffold Model for Circadian Gene Regulation
Disruption of the ternary complex by BRCA1 mutations or #circadian misalignment may mechanistically link #cancer risk to circadian disruption.
www.sciencedirect.com/science/arti...
Disruption of the ternary complex by BRCA1 mutations or #circadian misalignment may mechanistically link #cancer risk to circadian disruption.
www.sciencedirect.com/science/arti...
November 30, 2025 at 12:28 PM
The PER2:BRCA1:POU2F1(OCT-1) Ternary Complex Represents a Multi-Component Scaffold Model for Circadian Gene Regulation
Disruption of the ternary complex by BRCA1 mutations or #circadian misalignment may mechanistically link #cancer risk to circadian disruption.
www.sciencedirect.com/science/arti...
Disruption of the ternary complex by BRCA1 mutations or #circadian misalignment may mechanistically link #cancer risk to circadian disruption.
www.sciencedirect.com/science/arti...
TCA cycle enzyme activity of citrate synthase, succinate, and malate dehydrogenases as a function of LMF and their non-linear fittings.
November 30, 2025 at 7:40 AM
TCA cycle enzyme activity of citrate synthase, succinate, and malate dehydrogenases as a function of LMF and their non-linear fittings.
Mitochondrial respiration as a function of applied LMF.
November 29, 2025 at 6:42 PM
Mitochondrial respiration as a function of applied LMF.