9/ Collaborative efforts spanning disciplines and geographies were crucial for this work 🇦🇷🇺🇾🇺🇸🇨🇦. You have it here: www.nature.com/articles/s41...

8/ These findings suggest a novel aspect of coronavirus pathogenesis, highlighting potential therapeutic opportunities focused on targeting virus-heme interactions.

7/ A drug known to interact with heme/hemin impairs hemin’s pro-infective effect, reducing systemic infection. This further supports the hypothesis of heme-enhanced infection.

6/ Intriguingly, hemin (a heme analog) administration in infected mice elevated viral loads in organs and RBCs, underscoring the role of heme, and potentially hemoproteins, in enhancing viral infectivity.

5/ Spectroscopic analysis revealed that SARS-CoV-2 Spike protein interacts with hemin, altering its absorption spectrum.

4/ Using in silico molecular modeling 🖥, we predicted specific binding interactions between Spike and heme, revealing a potential mechanism that supports viral dissemination.

3/ We observed viral particles closely associated to red blood cells (RBCs) by proteomics and high-resolution transmission electron microscopy. These findings highlight a potential mechanism for Coronaviruses’ systemic spread ✈️

2/ Employing “the Polio virus” of coronaviruses, MHV, and its natural host 🐁 , we detected viral RNA and particles across multiple organs and blood 🩸 compartments, corroborating systemic tropism observed in our data from human autopsy.

Grande Nacho!!! Acá estoy atrás de un par de carretas y el morocho Ansina metiendo “la redota”!!!