Giorgio Seano
@giorgioseano.bsky.social
Head of the Tumor Microenvironment Laboratory at Institut Curie. #CancerResearch, #Neuro-oncology, #BrainTumor, #GBM, #Glioblastoma, #ResistanceMechanism, #TumorMicroenrironment, #TME, #Mechanobiology, #CellPlasticity
https://institut-curie.org/team/seano
https://institut-curie.org/team/seano
I'm really looking forward to the scientific discussions and hope to spark some new collaborations. See you there!
October 16, 2025 at 7:45 AM
I'm really looking forward to the scientific discussions and hope to spark some new collaborations. See you there!
It is a true honor to have this opportunity to share our results at such a prestigious meeting again. If you are around, please come to my talk (OS05.7.A), see @valentino-ribecco.bsky.social presentation (OS03.6.A), and stop by Juliette Reveilles (P02.09.B) and Adrien Thomas' (P04.12.A) posters.
October 16, 2025 at 7:45 AM
It is a true honor to have this opportunity to share our results at such a prestigious meeting again. If you are around, please come to my talk (OS05.7.A), see @valentino-ribecco.bsky.social presentation (OS03.6.A), and stop by Juliette Reveilles (P02.09.B) and Adrien Thomas' (P04.12.A) posters.
You can dive into all the multi-omics data and findings in the full paper.
Read more: doi.org/10.1093/neuo....
🧵 (9/9)
Read more: doi.org/10.1093/neuo....
🧵 (9/9)
Proneural-Mesenchymal hybrid glioblastoma cells are resistant to therapy and dependent on nuclear import
AbstractBackground. Despite extensive research efforts, glioblastoma (GBM) remains a deadly disease with poor prognosis. Although previous studies have ide
doi.org
July 17, 2025 at 9:08 AM
You can dive into all the multi-omics data and findings in the full paper.
Read more: doi.org/10.1093/neuo....
🧵 (9/9)
Read more: doi.org/10.1093/neuo....
🧵 (9/9)
🌟 Special thanks to @eanoassociation.bsky.social for sharing our work, and heartfelt gratitude to the @erc.europa.eu, @fondationarc.bsky.social @institutcurie.bsky.social and @cnrsbiologie.bsky.social for their generous support. (8/9)
July 17, 2025 at 9:08 AM
🌟 Special thanks to @eanoassociation.bsky.social for sharing our work, and heartfelt gratitude to the @erc.europa.eu, @fondationarc.bsky.social @institutcurie.bsky.social and @cnrsbiologie.bsky.social for their generous support. (8/9)
🙏 This research wouldn’t have been possible w/o the work of Oceane Anezo, Jeremy Raymond, Alberto Ballestín, Cathy Pichol-Thievend, Juliette Reveilles, Adrien Thomas, @valentino-ribecco.bsky.social, and the collaboration with Celine Vallot, @ggargiul.bsky.social , Vidhya M. Ravi, Kevin Joseph (7/9)
July 17, 2025 at 9:08 AM
🙏 This research wouldn’t have been possible w/o the work of Oceane Anezo, Jeremy Raymond, Alberto Ballestín, Cathy Pichol-Thievend, Juliette Reveilles, Adrien Thomas, @valentino-ribecco.bsky.social, and the collaboration with Celine Vallot, @ggargiul.bsky.social , Vidhya M. Ravi, Kevin Joseph (7/9)
🎉 Huge congrats to Guillaume Bourmeau, leading author and my brilliant PhD student, for spearheading this work on GBM hybrid cells at @institutcurie.bsky.social! Your dedication made this breakthrough possible. (6/9)
#ProudPI,
#ProudPI,
July 17, 2025 at 9:08 AM
🎉 Huge congrats to Guillaume Bourmeau, leading author and my brilliant PhD student, for spearheading this work on GBM hybrid cells at @institutcurie.bsky.social! Your dedication made this breakthrough possible. (6/9)
#ProudPI,
#ProudPI,
🚀 Here's the exciting part: we can target this vulnerability.
We hit them with importazole (import blocker) and selinexor (export inhibitor).
🔥 Targeting nuclear import decreases the hybrid cell pool and enhances chemoradiation sensitivity, opening a new therapeutic avenue against GBM. (5/9)
We hit them with importazole (import blocker) and selinexor (export inhibitor).
🔥 Targeting nuclear import decreases the hybrid cell pool and enhances chemoradiation sensitivity, opening a new therapeutic avenue against GBM. (5/9)
July 17, 2025 at 9:08 AM
🚀 Here's the exciting part: we can target this vulnerability.
We hit them with importazole (import blocker) and selinexor (export inhibitor).
🔥 Targeting nuclear import decreases the hybrid cell pool and enhances chemoradiation sensitivity, opening a new therapeutic avenue against GBM. (5/9)
We hit them with importazole (import blocker) and selinexor (export inhibitor).
🔥 Targeting nuclear import decreases the hybrid cell pool and enhances chemoradiation sensitivity, opening a new therapeutic avenue against GBM. (5/9)
🛡️ Therefore, these cells are resistant to treatment and are linked to a poorer patient prognosis. Using RNA-seq, nuclear proteome and scChIP-Seq, we discovered their Achilles' heel: a hyperactive nuclear transport system they rely on to import oncogenes like MYC and maintain their state. (4/9)
July 17, 2025 at 9:08 AM
🛡️ Therefore, these cells are resistant to treatment and are linked to a poorer patient prognosis. Using RNA-seq, nuclear proteome and scChIP-Seq, we discovered their Achilles' heel: a hyperactive nuclear transport system they rely on to import oncogenes like MYC and maintain their state. (4/9)
🤯 These hybrid cells don’t just look different, they proliferate like they’re on Red Bull and shrug off DNA damage after irradiation. Have they got superhuman repair skills? 🙄 (3/9)
a cartoon drawing of a person holding a pencil with a lightning bolt around it
ALT: a cartoon drawing of a person holding a pencil with a lightning bolt around it
media.tenor.com
July 17, 2025 at 9:08 AM
🤯 These hybrid cells don’t just look different, they proliferate like they’re on Red Bull and shrug off DNA damage after irradiation. Have they got superhuman repair skills? 🙄 (3/9)
🔬 Using dual fluorescent reporters for proneural & mesenchymal states, we tracked live patient-derived glioblastoma lines and uncovered a hybrid population expressing both signatures... let's talk about an identity crisis! (2/9)
a man is peeking through a doorway and smiling .
ALT: a man is peeking through a doorway and smiling .
media.tenor.com
July 17, 2025 at 9:08 AM
🔬 Using dual fluorescent reporters for proneural & mesenchymal states, we tracked live patient-derived glioblastoma lines and uncovered a hybrid population expressing both signatures... let's talk about an identity crisis! (2/9)
Of course! Done…
February 16, 2025 at 12:04 PM
Of course! Done…