Kuldeep Ghosh
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ghoshbabu88.bsky.social
Kuldeep Ghosh
@ghoshbabu88.bsky.social
PCCM fellow @WestchesterMed, former IDfellow @WestchesterMed. #fungalinfections #Tuberculosis #ECMOinfections #ARDS #POCUS
Reposted by Kuldeep Ghosh
Congratulations to the @accpchest.bsky.social on their 90th Anniversary and the declaration of Love Your Lungs Day in Chicago! On #LoveYourLungs Day, we stand with CHEST to raise awareness for lung health and to recognize the dedication of those working in health care.
October 19, 2025 at 3:00 PM
Reposted by Kuldeep Ghosh
🆕💫Multicenter matched cohort study
Among 8492 patients hospitalized patients with community-acquired pneumonia, azithromycin was associated with a lower mortality and more hospital free days compared to doxycycline in combination with beta-lactams #idsky #EMIMCC
academic.oup.com/cid/article-...
Comparative effectiveness of azithromycin versus doxycycline in hospitalized patients with community acquired pneumonia treated with beta-lactams: A multicenter matched cohort study
academic.oup.com
May 16, 2025 at 8:56 PM
Reposted by Kuldeep Ghosh
🆕💫 Systematic Review and Meta-Analysis
30 observational studies( SNAP & CloCeBa not included)
N: 3869
Cefazolin versus Antistaphylococcal Penicillins for the Treatment of MSSA Bacteremia #idsky
www.clinicalmicrobiologyandinfection.com/article/S119...
Cefazolin versus Antistaphylococcal Penicillins for the Treatment of Methicillin-Susceptible Staphylococcus aureus Bacteremia: A Systematic Review and Meta-Analysis
There is debate on whether cefazolin or antistaphylococcal penicillins should be the first-line treatment for methicillin-susceptible Staphylococcus aureus (MSSA) bacteremia. Ongoing trials are invest...
www.clinicalmicrobiologyandinfection.com
May 9, 2025 at 9:55 AM
Reposted by Kuldeep Ghosh
Systematic review (2k pts in 15 studies)on use of MRSA nares to de-escalate antibiotics in SSTIs:

👃 pooled specificity: 0.949, sensitivity of 0.474 😳
🦠 MRSA infection: 29% prevalence in studies; PPV: .798, NPV: .815

Test performance for SSTI <
www.cambridge.org/core/journal...

#IDSky
Testing for methicillin-resistant Staphylococcus aureus in the anterior nares for antibiotic de-escalation in patients presenting with acute skin and soft tissue infections: systematic review and meta...
Testing for methicillin-resistant Staphylococcus aureus in the anterior nares for antibiotic de-escalation in patients presenting with acute skin and soft tissue infections: systematic review and meta...
www.cambridge.org
April 25, 2025 at 2:59 AM
Reposted by Kuldeep Ghosh
New multi-center 🇫🇷, ECMO cannula inf study:

With broad definition: “either inflammatory signs at cannula or general signs of infection w/ + microbial sampling of cannula”

“Infections” often polymicrobial and require <8 days of abx

#IDSky

annalsofintensivecare.springeropen.com/articles/10....
Characteristics and outcomes of ECMO cannula-related infections: a European multicenter retrospective study - Annals of Intensive Care
Objective Only few data regarding epidemiology and management of ECMO cannula-related infections (ECMO-CRIs) exist. The aim of our study was to describe their epidemiology and prognosis, and to evalua...
annalsofintensivecare.springeropen.com
March 23, 2025 at 11:22 PM
Reposted by Kuldeep Ghosh
PEN-FAST-ED

In this prospective observational study from 🇺🇸, 58 ED patients with a PEN-FAST score of 3 or below were given beta-lactam antibiotics.
None of them developed any immune-mediated reactions.

doi.org/10.1016/j.aj...

#IDSky
March 16, 2025 at 4:02 AM
Reposted by Kuldeep Ghosh
Neutrophils can paradoxically aid in resolving inflammation by actively producing anti-inflammatory extracellular vesicles.

www.cell.com/cell/abstrac...
Neutrophil-derived vesicles control complement activation to facilitate inflammation resolution
Short-lived neutrophils are typically known for their pro-inflammatory role in pathogen clearance. This study highlights the formation of CD55+ LAND-Vs produced from aging neutrophils as a key mechani...
www.cell.com
March 2, 2025 at 10:18 AM
Reposted by Kuldeep Ghosh
Climate change contributes to the spread of Histoplasma & Blastomyces spp!
🆕💫 Review article @cmicomms.bsky.social @germatologist.bsky.social @mikescolarici.bsky.social
Histoplasmosis & Blastomycosis Progress & Possibilities
Similarities & Differences #idsky
www.sciencedirect.com/science/arti...
February 21, 2025 at 1:06 PM
Reposted by Kuldeep Ghosh
New 🇺🇸 single center pediatric ECMO paper evaluating daily 🩸 cultures.

⬇️ positivity rate (3%)

All had a clinical or lab change at time of pos culture (respiratory decline, hypotension, etc.)

ECMO centers should NOT be getting daily BCx

#IDSky

journals.lww.com/pccmjournal/...
Daily Surveillance Blood Cultures in Children Supported... : Pediatric Critical Care Medicine
ariability exists among ECMO centers regarding routine blood cultures for surveillance of BSI. Our study aimed to evaluate daily surveillance blood cultures in pediatric and neonatal ECMO patients. D...
journals.lww.com
February 8, 2025 at 3:47 PM
Reposted by Kuldeep Ghosh
Antibiotic prophylaxis for SBP in cirrhosis has been standard of care since the 1990s—but is the evidence strong enough to support it? Time to rethink this practice!
Excellent commentary @cidjournal.bsky.social
#IDsky #ASEPTICRCT academic.oup.com/cid/article/do…academic.oup.com/cid/advance-...te
February 4, 2025 at 4:43 PM
Reposted by Kuldeep Ghosh
Post-hoc analysis of 📷 📷 study in MSSA/MRSA bacteremia:

Persistent fever = indicator for complicated infection

Fever on Day 4️⃣: aOR (3.7 (95% CI: 1.58-8.67)) mortality
Fever on Day 7️⃣: aOR: (8.78 (95% CI: 2.78-27.7)

🚫 assn between ⬆️CRP/WBC and mortality

#IDSky

academic.oup.com/ofid/advance...
Association of daily body temperature, white blood cell count, and C-reactive protein with mortality and persistent bacteremia in patients with Staphylococcus aureus bacteremia: a post-hoc analysis of...
AbstractIntroduction. Classification of patients with Staphylococcus aureus bacteremia (SAB) as complicated versus uncomplicated is based on a combination
academic.oup.com
January 31, 2025 at 2:33 AM
Reposted by Kuldeep Ghosh
Blood culture use by floor in 🇺🇸 🏥 per 1000 pt days:

🥇273.1 for medical ICUs
🥈146.0 for medical-surgical ICUs
🥉80.3 for medical wards
4️⃣65.1 for medical-surgical ward

Positivity rates 🟰in all units (6-7%)
⬆️ use in 🏥 w/ 500 beds

#IDSky

jamanetwork.com/journals/jam...
Blood Culture Use in Medical and Surgical Intensive Care Units and Wards
This cross-sectional study describes blood culture use in US hospital intensive care units and wards.
jamanetwork.com
January 26, 2025 at 10:05 PM
Reposted by Kuldeep Ghosh
Exciting times in ECMO infections as ECCMID just announced two sessions in their 2025 program!

This adds to ECCMID 2024 and IDWeek 2024!
January 19, 2025 at 10:39 PM
Reposted by Kuldeep Ghosh
With everything so seemingly terrible these days & no sign of anything remotely hopeful in the near future, I thought you might need this photo of a baby giraffe.
January 17, 2025 at 12:27 AM
Reposted by Kuldeep Ghosh
🆕💫 Narrative Review @cmicomms.bsky.social
@jeffpears0n.bsky.social
Tetracyclines, the Old and the New
🔹Tetracycline 1953
✨Doxycycline 1967
🔹Minocycline 1971
🔹Tigecycline 2005
🔹Eravacycline 2018
🔹Omadacycline 2018
#IDsky #EMIMCC
www.sciencedirect.com/science/arti...
January 13, 2025 at 11:20 AM
Reposted by Kuldeep Ghosh
19,764 S. aureus isolates were collected from patients with various infection types at 37 US medical centers 2016 to 2022
MRSA (8,184) isolates:
Bactrim: 95% S
Clindamycin: 74% S
Vancomycin: 100% S
MDR MRSA (2,421) isolates:
Bactrim: 85% S
Clindamycin: 17% S
Vancomycin: 100% S #idsky
January 13, 2025 at 10:11 PM
What if I drink coffee in morning and later in day 😜😜
Coffee drinking timing and mortality in US adults

"Drinking coffee in the morning may be more strongly associated with a lower risk of mortality than drinking coffee later in the day."

academic.oup.com/eurheartj/ad...
January 13, 2025 at 5:18 AM
Reposted by Kuldeep Ghosh
I've been wondering about NTM/TB cross-immunity for a while, so this was interesting: rdcu.be/d51g8
Evaluation of the cross-immunity between Mycobacterium tuberculosis and Mycobacterium abscessus in vitro | BMC Microbiology
rdcu.be
January 12, 2025 at 10:49 AM
Reposted by Kuldeep Ghosh
New article on synergy with combination therapy in MRSA with:

Vancomycin or Ceftaroline + Carbapenem ?!?!

I love the work to find MOA, but interpret with caution after 📷-2

Has anyone used combination Vanc or Ceftaroline + carbapenem in MRSA infections?

academic.oup.com/jid/advance-...
Enhanced Killing of Methicillin-Resistant Staphylococcus aureus with Ceftaroline or Vancomycin in Combination with Carbapenems
Carbapenems (ertapenem/meropenem) enhance the efficacy of ceftaroline or vancomycin against MRSA. Results demonstrate in vitro and in vivo synergy, reduced
academic.oup.com
January 9, 2025 at 2:59 AM
Reposted by Kuldeep Ghosh
Treating bloodstream infections caused by antibiotic-resistant bacteria in India costs 54% more than treating infections that respond to antibiotics. This highlights the economic burden of AMR and the need for stronger prevention and control measures.

theprint.in/health/life-...
Life-threatening bloodstream infections 54% costlier to treat when caused by superbugs—ICMR study
Study conducted by 13 organisations found that in govt hospitals, direct median total cost for treating bloodstream infections triggered by antimicrobial-resistant bacteria was Rs 89,377.
theprint.in
January 3, 2025 at 2:01 AM
Reposted by Kuldeep Ghosh

**Starting 2025 with a key update:
The new ATS/CDC/ERS/IDSA guidelines on treating drug-susceptible and drug-resistant tuberculosis (TB) are out!
What do you think about these changes? How will they shape clinical practice moving forward?**
#idsky #tbsky #EMIMCC
🆕🔥Just published 🔥🆕
Updates on the Treatment of Drug-Susceptible and Drug-Resistant Tuberculosis(TB)
An Official ATS/CDC/ERS/IDSA Clinical Practice Guideline #idsky #TBsky
www.atsjournals.org/doi/full/10....
January 2, 2025 at 7:10 PM
Reposted by Kuldeep Ghosh
T-SPOT resulted in
- fewer indeterminate results (than QFT)
- more “actionable” results (than QFT)

in certain immunocompromised populations #TBSky
Out now in @thetxidjournal.bsky.social!

T-SPOT.TB is more likely to produce actionable results than QFT-TB in patients with cancer being screened for latent TB.

#TxID #IDSky

onlinelibrary.wiley.com/doi/10.1111/...
December 29, 2024 at 1:18 AM
Merry Christmas and Happy holidays!!
December 25, 2024 at 10:52 AM
Reposted by Kuldeep Ghosh
2024 was an exciting year in the world of ECMO infections research

Some highlights below:

A 🧵

#IDSky
December 23, 2024 at 8:32 PM