Among 8492 patients hospitalized patients with community-acquired pneumonia, azithromycin was associated with a lower mortality and more hospital free days compared to doxycycline in combination with beta-lactams #idsky #EMIMCC
academic.oup.com/cid/article-...
Among 8492 patients hospitalized patients with community-acquired pneumonia, azithromycin was associated with a lower mortality and more hospital free days compared to doxycycline in combination with beta-lactams #idsky #EMIMCC
academic.oup.com/cid/article-...
30 observational studies( SNAP & CloCeBa not included)
N: 3869
Cefazolin versus Antistaphylococcal Penicillins for the Treatment of MSSA Bacteremia #idsky
www.clinicalmicrobiologyandinfection.com/article/S119...
30 observational studies( SNAP & CloCeBa not included)
N: 3869
Cefazolin versus Antistaphylococcal Penicillins for the Treatment of MSSA Bacteremia #idsky
www.clinicalmicrobiologyandinfection.com/article/S119...
👃 pooled specificity: 0.949, sensitivity of 0.474 😳
🦠 MRSA infection: 29% prevalence in studies; PPV: .798, NPV: .815
Test performance for SSTI <
www.cambridge.org/core/journal...
#IDSky
👃 pooled specificity: 0.949, sensitivity of 0.474 😳
🦠 MRSA infection: 29% prevalence in studies; PPV: .798, NPV: .815
Test performance for SSTI <
www.cambridge.org/core/journal...
#IDSky
With broad definition: “either inflammatory signs at cannula or general signs of infection w/ + microbial sampling of cannula”
“Infections” often polymicrobial and require <8 days of abx
#IDSky
annalsofintensivecare.springeropen.com/articles/10....
With broad definition: “either inflammatory signs at cannula or general signs of infection w/ + microbial sampling of cannula”
“Infections” often polymicrobial and require <8 days of abx
#IDSky
annalsofintensivecare.springeropen.com/articles/10....
In this prospective observational study from 🇺🇸, 58 ED patients with a PEN-FAST score of 3 or below were given beta-lactam antibiotics.
None of them developed any immune-mediated reactions.
doi.org/10.1016/j.aj...
#IDSky
In this prospective observational study from 🇺🇸, 58 ED patients with a PEN-FAST score of 3 or below were given beta-lactam antibiotics.
None of them developed any immune-mediated reactions.
doi.org/10.1016/j.aj...
#IDSky
www.cell.com/cell/abstrac...
www.cell.com/cell/abstrac...
🆕💫 Review article @cmicomms.bsky.social @germatologist.bsky.social @mikescolarici.bsky.social
Histoplasmosis & Blastomycosis Progress & Possibilities
Similarities & Differences #idsky
www.sciencedirect.com/science/arti...
🆕💫 Review article @cmicomms.bsky.social @germatologist.bsky.social @mikescolarici.bsky.social
Histoplasmosis & Blastomycosis Progress & Possibilities
Similarities & Differences #idsky
www.sciencedirect.com/science/arti...
⬇️ positivity rate (3%)
All had a clinical or lab change at time of pos culture (respiratory decline, hypotension, etc.)
ECMO centers should NOT be getting daily BCx
#IDSky
journals.lww.com/pccmjournal/...
⬇️ positivity rate (3%)
All had a clinical or lab change at time of pos culture (respiratory decline, hypotension, etc.)
ECMO centers should NOT be getting daily BCx
#IDSky
journals.lww.com/pccmjournal/...
Excellent commentary @cidjournal.bsky.social
#IDsky #ASEPTICRCT academic.oup.com/cid/article/do…academic.oup.com/cid/advance-...te
Excellent commentary @cidjournal.bsky.social
#IDsky #ASEPTICRCT academic.oup.com/cid/article/do…academic.oup.com/cid/advance-...te
Persistent fever = indicator for complicated infection
Fever on Day 4️⃣: aOR (3.7 (95% CI: 1.58-8.67)) mortality
Fever on Day 7️⃣: aOR: (8.78 (95% CI: 2.78-27.7)
🚫 assn between ⬆️CRP/WBC and mortality
#IDSky
academic.oup.com/ofid/advance...
Persistent fever = indicator for complicated infection
Fever on Day 4️⃣: aOR (3.7 (95% CI: 1.58-8.67)) mortality
Fever on Day 7️⃣: aOR: (8.78 (95% CI: 2.78-27.7)
🚫 assn between ⬆️CRP/WBC and mortality
#IDSky
academic.oup.com/ofid/advance...
🥇273.1 for medical ICUs
🥈146.0 for medical-surgical ICUs
🥉80.3 for medical wards
4️⃣65.1 for medical-surgical ward
Positivity rates 🟰in all units (6-7%)
⬆️ use in 🏥 w/ 500 beds
#IDSky
jamanetwork.com/journals/jam...
🥇273.1 for medical ICUs
🥈146.0 for medical-surgical ICUs
🥉80.3 for medical wards
4️⃣65.1 for medical-surgical ward
Positivity rates 🟰in all units (6-7%)
⬆️ use in 🏥 w/ 500 beds
#IDSky
jamanetwork.com/journals/jam...
This adds to ECCMID 2024 and IDWeek 2024!
This adds to ECCMID 2024 and IDWeek 2024!
@jeffpears0n.bsky.social
Tetracyclines, the Old and the New
🔹Tetracycline 1953
✨Doxycycline 1967
🔹Minocycline 1971
🔹Tigecycline 2005
🔹Eravacycline 2018
🔹Omadacycline 2018
#IDsky #EMIMCC
www.sciencedirect.com/science/arti...
@jeffpears0n.bsky.social
Tetracyclines, the Old and the New
🔹Tetracycline 1953
✨Doxycycline 1967
🔹Minocycline 1971
🔹Tigecycline 2005
🔹Eravacycline 2018
🔹Omadacycline 2018
#IDsky #EMIMCC
www.sciencedirect.com/science/arti...
MRSA (8,184) isolates:
Bactrim: 95% S
Clindamycin: 74% S
Vancomycin: 100% S
MDR MRSA (2,421) isolates:
Bactrim: 85% S
Clindamycin: 17% S
Vancomycin: 100% S #idsky
journals.asm.org/doi/10.1128/...
MRSA (8,184) isolates:
Bactrim: 95% S
Clindamycin: 74% S
Vancomycin: 100% S
MDR MRSA (2,421) isolates:
Bactrim: 85% S
Clindamycin: 17% S
Vancomycin: 100% S #idsky
"Drinking coffee in the morning may be more strongly associated with a lower risk of mortality than drinking coffee later in the day."
academic.oup.com/eurheartj/ad...
Vancomycin or Ceftaroline + Carbapenem ?!?!
I love the work to find MOA, but interpret with caution after 📷-2
Has anyone used combination Vanc or Ceftaroline + carbapenem in MRSA infections?
academic.oup.com/jid/advance-...
Vancomycin or Ceftaroline + Carbapenem ?!?!
I love the work to find MOA, but interpret with caution after 📷-2
Has anyone used combination Vanc or Ceftaroline + carbapenem in MRSA infections?
academic.oup.com/jid/advance-...
theprint.in/health/life-...
theprint.in/health/life-...
**Starting 2025 with a key update:
The new ATS/CDC/ERS/IDSA guidelines on treating drug-susceptible and drug-resistant tuberculosis (TB) are out!
What do you think about these changes? How will they shape clinical practice moving forward?**
#idsky #tbsky #EMIMCC
Updates on the Treatment of Drug-Susceptible and Drug-Resistant Tuberculosis(TB)
An Official ATS/CDC/ERS/IDSA Clinical Practice Guideline #idsky #TBsky
www.atsjournals.org/doi/full/10....
- fewer indeterminate results (than QFT)
- more “actionable” results (than QFT)
in certain immunocompromised populations #TBSky
T-SPOT.TB is more likely to produce actionable results than QFT-TB in patients with cancer being screened for latent TB.
#TxID #IDSky
onlinelibrary.wiley.com/doi/10.1111/...
- fewer indeterminate results (than QFT)
- more “actionable” results (than QFT)
in certain immunocompromised populations #TBSky