Thanks for this! The study was all over the news in Germany, but somehow I never cared to check. As a scientist myself I really should have 🙄 Overselling scientific findings is really a problem in our days - it decreases trust in the scientific process...

Und ich dachte es sei ein Witz... 😂 Olli glaube ich auch, oder zumindest hat er so getan...

Only have some slides to explain protein domains and the importance to predict those to a public audience. Not sure if those help... 🤷‍♂️

Full ack... Sadly the AI proponents often do not share our caution 😉

I see your point, but I've heard this argument to often. "AF is different? - maybe just an important different confomer!" I do agree that crystal artefact exists and maybe this one deviation is upsold a little bit in the article, but in principle it's important to strengthen experimental strubio.

Is Folding@Home still a thing? I have the impression neuronal network based methods have outpaced the energy based prediction software so far....or did they change the basis for the client? 🤔

Not so fond of the war theme, but I agree with the message👍. I see so many projects just doing fancy -omics, trying to solve mechanisms - but sometimes you just have to get your hands dirty and purify that f*** protein.

room for improvement - it is an essential part of the scientific progress... So, is this just me?

Don't get me wrong, the study seems legit and I am eager to dig into it. Although every bit of focus on collagens research is great. But I don't like this "new" trend on reporting on practically unpublished results. I think we have a peer-review system for a reason and while there might be (2/n)

I am a structural biologist working with collagens, so naturally I am very interested. I only had time to skim over the paper, but I have to admit I currently fail to see why this is _major_ news. Especially, as it is not yet peer-reviewed. I frankly have more questions than answers (1/n)

I have the feeling that we lived in the golden age of medicine, already before AF. Knockouts mice, crispr/cas, mRNA vacs.These are all tremendous developments - independent of AF. Don't get me wrong: I am a structural biologist and use AF every day. It's great, but medicine was great already before

Thank you 🙏

Thanks! Finally I found it... 🥰 Somehow, expected it would be coot-1 or something along that line...

Thanks 👍

Hi, could you please add me to the science feed? I am a structural biologist. You'll find the University facility I supervise here px.uni-koeln.de and papers on my own page Gebauer.koeln thanks a lot!

I also thought about protein structures, but there is no left-handed alpha helix 🤔 but maybe that's the point? On the other hand the zigzag is not disordered... Frankly no idea... From which science area is it?

And still, it's relatively often wrong - at least for protein complexes 😉

This sounds interesting and maybe exactly what I need. Plan to di some screening with #AF3 and a proper implementation ofna scoring function was still missing 👍 thanks!