Ed Cunningham-Oakes
edcoakes.bsky.social
Ed Cunningham-Oakes
@edcoakes.bsky.social
📍 Birmingham
👨🏾‍💻 Bioinformatics and EDI
💭 Microbiome and Genomic Diagnostics
🦠 HPRU in Public Health Genomics
🏋🏾‍♂️ Powerlifter
Views and typos my own
12/12 📰 For more background and wider context, check out the @liverpooluni.bsky.social press release covering this study’s impact on understanding and diagnosing infectious intestinal diseases: news.liverpool.ac.uk/2025/05/20/a...
Advanced genomics study improves detection of hard-to-find diarrhoeal infections - University of Liverpool News
Advanced genomics study improves detection of hard-to-find diarrhoeal infections
news.liverpool.ac.uk
May 20, 2025 at 9:42 AM
11/12 🙏 A big thank you to all my amazing collaborators who made this work possible @blancaps.bsky.social @jayhinton.bsky.social @acdarby.bsky.social (PI) and many of the INTEGRATE consortium not on BlueSky.
Thank you to @nihr.bsky.social for funding via the second HPRU-GI @livuni-ives.bsky.social.
May 20, 2025 at 9:41 AM
10/12 🔍 This dual-omics approach captures both what pathogens are present and what they're doing, offering unmatched resolution for understanding infectious intestinal disease biology.
May 20, 2025 at 9:37 AM
9/12 📊 RNA/DNA ratios differed significantly between positive and negative cases, helping distinguish true infection from bystander carriage and providing a molecular readout of microbial activity.
May 20, 2025 at 9:37 AM
8/12 📦 Critically, RNA in stool remained stable enough for pathogen detection without preservatives (and after self-sample and surviving the mail service!), providing evidence for the routine potential of metatranscriptomics in clinical settings (with some work!)
May 20, 2025 at 9:36 AM