Rafał Marecki
LightNews LightNews
druidzaklinacz.bsky.social
Rafał Marecki
@druidzaklinacz.bsky.social
190 followers 780 following 10 posts
🩺 Physician 🧪 PhD candidate
🧠 Neurosteroids and psychedelics research
🧑🏻‍🏫 I educate high school students on depression, exam stress and getting help.
Białystok, Poland
he/him
Posts Replies Media Videos
druidzaklinacz.bsky.social
He reasons that education shouldn't be influenced by left nor right ideology. Maybe education should have such autonomy as judiciary?
January 13, 2025 at 12:55 AM
druidzaklinacz.bsky.social
To mock this system prof. Konrad Szacilowski published an article on matches collecting as John Paul II's hobby.
www.researchgate.net/publication/...
(PDF) Filumenistyczne hobby Karola Wojtyły
PDF | The article presents a little-known side of the Pope’s life, his passion for collecting matches. The introduction shows that John Paul II was not... | Find, read and cite all the research you ne...
www.researchgate.net
November 30, 2024 at 10:12 AM
druidzaklinacz.bsky.social
When I published a review on Zuranolone Frontiers in Psychiatry had 140 points, but I could publish in "Pedagogika Katolicka" ("Catholic Pedagogics") with 200 points and 0 IF.
November 30, 2024 at 10:12 AM
druidzaklinacz.bsky.social
The fun starts when you realize this score is used to decide refunds and grants. For example, when I started PhD I needed to publish in a journal with 140 points to get a 100% refund from the university and 100 to get a 60%.
November 30, 2024 at 10:12 AM
Reposted by Rafał Marecki
castltrastondrs.bsky.social
#neurosteroids replacement therapy (NRT) with GABA-A receptor-modulating allopregnanolone (brexanolone) PPD affects 500000 women in 🇺🇸 annually. BX is 1st #neurosteroid approved for PPD and marks a significant milestone in the field of #neuropsychopharmacology

www.cell.com/trends/molec...
BX’s mechanism in postpartum depression (PPD) involves elevating brain allopregnanolone (AP), which may decrease significantly at postpartum, back to third trimester levels. AP acts as a preferential allosteric modulator and direct activator of extrasynaptic δGABA-ARs, which causes persistent hyperpolarization of neurons and shunts network hyperexcitability. Although the precise binding location is unclear, both activation and potentiation functions of AP apparently proceed from a single interfacial binding site, specifically at the α-subunit lipid interface. AP enhances the receptor function by binding to ‘neurosteroid binding’ sites, which are distinct from sites for GABA and benzodiazepines. Based on their location and kinetics, GABA-ARs are stratified into two groups. Synaptic receptors (α1β2γ2 subunits) mediate phasic inhibition in response to presynaptic release of GABA, while extrasynaptic receptors (α4β2δ subunits) primarily contribute to tonic inhibition in response to ambient
January 4, 2024 at 11:59 AM