Lucy MacDonald
@drlucymac.bsky.social
Research Associate at School of Infection and Immunity, University of Glasgow 🏴
Mapping macrophage & DC niches with single cell spatial transcriptomics 🔬🧭
Mapping macrophage & DC niches with single cell spatial transcriptomics 🔬🧭
Thank you Julia!
November 27, 2024 at 9:17 PM
Thank you Julia!
Highlights
• Tolerogenic AXL+ DC2s reside beneath the healthy synovial lining
• iDC3s populate RA hyperplastic lining, activating CCL5 Tem and/or Tph cells
• CCR7+ DC2s in sublining lymphoid niches in RA, interacting with naive T cells
• blood DC3s signature predicts RA flare
• Tolerogenic AXL+ DC2s reside beneath the healthy synovial lining
• iDC3s populate RA hyperplastic lining, activating CCL5 Tem and/or Tph cells
• CCR7+ DC2s in sublining lymphoid niches in RA, interacting with naive T cells
• blood DC3s signature predicts RA flare
November 27, 2024 at 6:38 PM
Highlights
• Tolerogenic AXL+ DC2s reside beneath the healthy synovial lining
• iDC3s populate RA hyperplastic lining, activating CCL5 Tem and/or Tph cells
• CCR7+ DC2s in sublining lymphoid niches in RA, interacting with naive T cells
• blood DC3s signature predicts RA flare
• Tolerogenic AXL+ DC2s reside beneath the healthy synovial lining
• iDC3s populate RA hyperplastic lining, activating CCL5 Tem and/or Tph cells
• CCR7+ DC2s in sublining lymphoid niches in RA, interacting with naive T cells
• blood DC3s signature predicts RA flare