Dr. Foxpaws Fauxpas M.D.
@dr-foxpaws-fauxpas.bsky.social
Clinical Oncologist, perpetual student, quizzer & digital artist.
Interests: GI, Gynec, Breast, Lung, GU, Lymphomas, CNS & palliative medicine.
Building towards a better quality of life for all patients 🐳
Alumnus of JIPMER, Pondicherry, India.
Interests: GI, Gynec, Breast, Lung, GU, Lymphomas, CNS & palliative medicine.
Building towards a better quality of life for all patients 🐳
Alumnus of JIPMER, Pondicherry, India.
One of the most common unnoticed electrolyte imbalance in cancer patients - Hypomagnesemia!
Do test when indicated by keeping it in your DDx !
Here's a quick run through of causes of ⬇️ Mg in Ca pts - especially keep in mind when using:
💊EGFRibs
💉Platins
💊TKIs
💉Anti HER2
#cancer #oncology #oncsky
Do test when indicated by keeping it in your DDx !
Here's a quick run through of causes of ⬇️ Mg in Ca pts - especially keep in mind when using:
💊EGFRibs
💉Platins
💊TKIs
💉Anti HER2
#cancer #oncology #oncsky
December 31, 2024 at 2:04 PM
Antibiotics at increased risk of clostridium difficile infection
Must know for every clinician!
#basics #pharmacology
Must know for every clinician!
#basics #pharmacology
December 29, 2024 at 2:12 PM
Antibiotics at increased risk of clostridium difficile infection
Must know for every clinician!
#basics #pharmacology
Must know for every clinician!
#basics #pharmacology
Revising FLIPI 1 & 2 in follicular lymphomas
Compared with m7 FLIPI - 7 gene Clinicogenetic score - validated in GALLIUM - RCHOP/RCVP
❌ in bendamustine regimens
⚡ EZH2 mutation status
-Bendamustine in EZH2 wild type FL
-CHOP/CVP in EZH2 mutated FL ✅ ⬆️ PFS
#lymsm #lymphoma #oncsky #basics
Compared with m7 FLIPI - 7 gene Clinicogenetic score - validated in GALLIUM - RCHOP/RCVP
❌ in bendamustine regimens
⚡ EZH2 mutation status
-Bendamustine in EZH2 wild type FL
-CHOP/CVP in EZH2 mutated FL ✅ ⬆️ PFS
#lymsm #lymphoma #oncsky #basics
December 28, 2024 at 12:49 PM
Here's a fan #art i made of my favorite #christmas movie!
What's christmas without an elf, a dwarf and a magic white bearded grandpa?
😄 Merry Christmas everyone!
What's christmas without an elf, a dwarf and a magic white bearded grandpa?
😄 Merry Christmas everyone!
December 25, 2024 at 7:32 AM
Here's a fan #art i made of my favorite #christmas movie!
What's christmas without an elf, a dwarf and a magic white bearded grandpa?
😄 Merry Christmas everyone!
What's christmas without an elf, a dwarf and a magic white bearded grandpa?
😄 Merry Christmas everyone!
4 diagnoses, 4 livers.
1 endless week.
Oncology can be pretty darn humbling.
Currently in a spiral of existentialism and confronting one's own mortality.
1 endless week.
Oncology can be pretty darn humbling.
Currently in a spiral of existentialism and confronting one's own mortality.
December 22, 2024 at 3:22 PM
4 diagnoses, 4 livers.
1 endless week.
Oncology can be pretty darn humbling.
Currently in a spiral of existentialism and confronting one's own mortality.
1 endless week.
Oncology can be pretty darn humbling.
Currently in a spiral of existentialism and confronting one's own mortality.
How do immuno modulatory agents work in #myeloma?
And why does Pomalidomide work even after progression on lenalidomide?
Tumor microenvironment plays a major role in myeloma and pathogenesis.
Ikarus Transcription factor is key.
#cancer #hemesky #blood #oncsky
@nihardesai7.bsky.social
And why does Pomalidomide work even after progression on lenalidomide?
Tumor microenvironment plays a major role in myeloma and pathogenesis.
Ikarus Transcription factor is key.
#cancer #hemesky #blood #oncsky
@nihardesai7.bsky.social
December 21, 2024 at 5:46 PM
ICI induced myocarditis ❤️🔥
🔬 Patho (EMBx) - Dallas Cx
Multifocal inflammatory infiltrates + overt cardiomyocyte loss
⚕️Clinical
cTn - new/significant ⬆️⬆️ from baseline
- with 1 major/2 minor criteria
- Exclude ACS/acute infectious myocarditis
#sabcs24 #cancer #bcsm #oncsky #cardio toxicity
🔬 Patho (EMBx) - Dallas Cx
Multifocal inflammatory infiltrates + overt cardiomyocyte loss
⚕️Clinical
cTn - new/significant ⬆️⬆️ from baseline
- with 1 major/2 minor criteria
- Exclude ACS/acute infectious myocarditis
#sabcs24 #cancer #bcsm #oncsky #cardio toxicity
December 12, 2024 at 5:30 PM
Trials supporting Immunotherapy in operable NSCLC
Slides courtesy of the incredible Dr Katsuaki Maehara @katsuaki-maehara.bsky.social
#LUNG #cancer #lcsm #oncsky
Slides courtesy of the incredible Dr Katsuaki Maehara @katsuaki-maehara.bsky.social
#LUNG #cancer #lcsm #oncsky
December 11, 2024 at 2:25 PM
Trials supporting Immunotherapy in operable NSCLC
Slides courtesy of the incredible Dr Katsuaki Maehara @katsuaki-maehara.bsky.social
#LUNG #cancer #lcsm #oncsky
Slides courtesy of the incredible Dr Katsuaki Maehara @katsuaki-maehara.bsky.social
#LUNG #cancer #lcsm #oncsky
Quiz time!
Which conventional chemotherapy agents of the below cannot cross BBB?
Capecitabine
Platinums
Temozolomide
Doxorubicin
#oncsky #chemotherapy #basics #brain #oncology
Below is an microanatomic depiction of physiological vs pathological BBB at a microscopic level.
Which conventional chemotherapy agents of the below cannot cross BBB?
Capecitabine
Platinums
Temozolomide
Doxorubicin
#oncsky #chemotherapy #basics #brain #oncology
Below is an microanatomic depiction of physiological vs pathological BBB at a microscopic level.
December 10, 2024 at 2:02 PM
Quiz time!
Which conventional chemotherapy agents of the below cannot cross BBB?
Capecitabine
Platinums
Temozolomide
Doxorubicin
#oncsky #chemotherapy #basics #brain #oncology
Below is an microanatomic depiction of physiological vs pathological BBB at a microscopic level.
Which conventional chemotherapy agents of the below cannot cross BBB?
Capecitabine
Platinums
Temozolomide
Doxorubicin
#oncsky #chemotherapy #basics #brain #oncology
Below is an microanatomic depiction of physiological vs pathological BBB at a microscopic level.
LEAP program - Lenva and Pembrolizumab in solid tumors
A comprehensive list of LEAP group trials
A summary of site-wise response rates and PFS
Interesting paper!
#oncology #oncsky #lcsm
www.tandfonline.com/doi/full/10....
A comprehensive list of LEAP group trials
A summary of site-wise response rates and PFS
Interesting paper!
#oncology #oncsky #lcsm
www.tandfonline.com/doi/full/10....
December 7, 2024 at 2:49 PM
LEAP program - Lenva and Pembrolizumab in solid tumors
A comprehensive list of LEAP group trials
A summary of site-wise response rates and PFS
Interesting paper!
#oncology #oncsky #lcsm
www.tandfonline.com/doi/full/10....
A comprehensive list of LEAP group trials
A summary of site-wise response rates and PFS
Interesting paper!
#oncology #oncsky #lcsm
www.tandfonline.com/doi/full/10....
⚡ Doses and indications of lenvatinib - for all FDA approved indications.
Along with dose reduction levels
A quick reckoner
Common Tox:
☢️Diarrhea
☢️Asthenia & mucositis
☢️Proteinuria & HTN
☢️Rash and PPE
#oncsky #chemotherapy #basics #oncology
Along with dose reduction levels
A quick reckoner
Common Tox:
☢️Diarrhea
☢️Asthenia & mucositis
☢️Proteinuria & HTN
☢️Rash and PPE
#oncsky #chemotherapy #basics #oncology
December 7, 2024 at 8:02 AM
⚡ Doses and indications of lenvatinib - for all FDA approved indications.
Along with dose reduction levels
A quick reckoner
Common Tox:
☢️Diarrhea
☢️Asthenia & mucositis
☢️Proteinuria & HTN
☢️Rash and PPE
#oncsky #chemotherapy #basics #oncology
Along with dose reduction levels
A quick reckoner
Common Tox:
☢️Diarrhea
☢️Asthenia & mucositis
☢️Proteinuria & HTN
☢️Rash and PPE
#oncsky #chemotherapy #basics #oncology
TCGA - Gastric Ca Molecular Classification
👁️ EBV - best outcomes following resection, notably absent in GEJ
❌ GS- Lauren Diffuse-poor outcomes, poor chemoresponse
🧬 CIN - Lauren Intestinal - benefit of adj chemo ⬆️
Snapshot of targeted therapies for Gastric adenoca
#gi #gastro #cancer #oncsky
👁️ EBV - best outcomes following resection, notably absent in GEJ
❌ GS- Lauren Diffuse-poor outcomes, poor chemoresponse
🧬 CIN - Lauren Intestinal - benefit of adj chemo ⬆️
Snapshot of targeted therapies for Gastric adenoca
#gi #gastro #cancer #oncsky
December 2, 2024 at 6:06 PM
👑 RCHOP remains king/queen in limited stage DLBCL.
✅ PET adapted therapy - best for assessing risk groups for recurrence.
✅ Polatuzumab - better for Non GCB subtype and elderly subgroup - at the cost of increased neuropathy
☢️RT if decreased chemo tolerance ⬇️
#lymphoma #oncsky #heme #cancers
✅ PET adapted therapy - best for assessing risk groups for recurrence.
✅ Polatuzumab - better for Non GCB subtype and elderly subgroup - at the cost of increased neuropathy
☢️RT if decreased chemo tolerance ⬇️
#lymphoma #oncsky #heme #cancers
December 1, 2024 at 1:10 AM
Patterns of meningeal metastases with radio DDx and spotters
🧠 Pachymeningeal - dural mets - MC - breast, prostate, and lung cancers
🧠Leptomeningeal - pia and arachnoid - MC - breast, lung, melanoma
#cancer #oncsky #brain #metastasis #radiology
Pic credits : Radiology Assistant
🧠 Pachymeningeal - dural mets - MC - breast, prostate, and lung cancers
🧠Leptomeningeal - pia and arachnoid - MC - breast, lung, melanoma
#cancer #oncsky #brain #metastasis #radiology
Pic credits : Radiology Assistant
November 30, 2024 at 1:48 PM
Patterns of meningeal metastases with radio DDx and spotters
🧠 Pachymeningeal - dural mets - MC - breast, prostate, and lung cancers
🧠Leptomeningeal - pia and arachnoid - MC - breast, lung, melanoma
#cancer #oncsky #brain #metastasis #radiology
Pic credits : Radiology Assistant
🧠 Pachymeningeal - dural mets - MC - breast, prostate, and lung cancers
🧠Leptomeningeal - pia and arachnoid - MC - breast, lung, melanoma
#cancer #oncsky #brain #metastasis #radiology
Pic credits : Radiology Assistant
When to avoid concurrent PPIs in #cancer treatment?
- antimetabolites
- immunorx
- TKIs
Although there is lack of strong randomised data re the same, retro data has shown diminishing efficacy with concurrent PPIs
What is the alternative?
#oncsky #chemotherapy #basics #oncology
- antimetabolites
- immunorx
- TKIs
Although there is lack of strong randomised data re the same, retro data has shown diminishing efficacy with concurrent PPIs
What is the alternative?
#oncsky #chemotherapy #basics #oncology
November 30, 2024 at 3:09 AM
When to avoid concurrent PPIs in #cancer treatment?
- antimetabolites
- immunorx
- TKIs
Although there is lack of strong randomised data re the same, retro data has shown diminishing efficacy with concurrent PPIs
What is the alternative?
#oncsky #chemotherapy #basics #oncology
- antimetabolites
- immunorx
- TKIs
Although there is lack of strong randomised data re the same, retro data has shown diminishing efficacy with concurrent PPIs
What is the alternative?
#oncsky #chemotherapy #basics #oncology
November 29, 2024 at 3:39 PM
