Abdel Abdellaoui
@dr-appie.bsky.social
Complex Trait Genetics | Population Genetics | Evolutionary Genetics
https://scholar.google.nl/citations?user=hsyseKEAAAAJ&hl=en
https://scholar.google.nl/citations?user=hsyseKEAAAAJ&hl=en
Pinned
Abdel Abdellaoui
@dr-appie.bsky.social
· Mar 26
In every civilization, people end up sorted into levels of socio-economic status (SES). We explore the history, present, and future of scientific research on the complicated relationship between SES and DNA in @naturehumbehav.bsky.social💰🧬🎓
Link: rdcu.be/efacK
Thread below 👇🏽
Link: rdcu.be/efacK
Thread below 👇🏽
Reposted by Abdel Abdellaoui
Behavioral, social and health scientists: if you’d like to combine social and genetic data, this is for you: shorturl.at/8gUcu. This course in London features all aspects from data collection to model estimation in our local cohort data - and the incredible @timtmorris.bsky.social as instructor.
Introduction to genetic data analysis in the social, behavioural, and health sciences
This 4-day course will provide social scientists with the knowledge and skills needed to analyse genetic data, critically interpret results, and integrate genetics into their research.
shorturl.at
November 13, 2025 at 3:59 PM
Behavioral, social and health scientists: if you’d like to combine social and genetic data, this is for you: shorturl.at/8gUcu. This course in London features all aspects from data collection to model estimation in our local cohort data - and the incredible @timtmorris.bsky.social as instructor.
Reposted by Abdel Abdellaoui
With sequencing of Hitler's DNA making headlines, time for a reminder: analysing a polygenic score from a dead historically-significant figure won't give new insights into that person's behaviour. In a brief paper last year, we used Beethoven's genome to directly illustrate the fallacies involved.🧪👇
Notes from Beethoven’s genome
Wesseldijk et al. compare the genomic information collected from Ludwig van Beethoven
with population-based datasets used to quantify musical achievement.
www.cell.com
November 13, 2025 at 11:26 AM
With sequencing of Hitler's DNA making headlines, time for a reminder: analysing a polygenic score from a dead historically-significant figure won't give new insights into that person's behaviour. In a brief paper last year, we used Beethoven's genome to directly illustrate the fallacies involved.🧪👇
Reposted by Abdel Abdellaoui
First time on Bsky and first big announcement!
I am excited to announce that our new study explaining the missing heritability of many phenotypes using WGS data from ~347,000 UK Biobank participants has just been published in @Nature.
Our manuscript is here: www.nature.com/articles/s41....
I am excited to announce that our new study explaining the missing heritability of many phenotypes using WGS data from ~347,000 UK Biobank participants has just been published in @Nature.
Our manuscript is here: www.nature.com/articles/s41....
Estimation and mapping of the missing heritability of human phenotypes - Nature
WGS data were used from 347,630 individuals with European ancestry in the UK Biobank to obtain high-precision estimates of coding and non-coding rare variant heritability for 34 co...
www.nature.com
November 12, 2025 at 5:57 PM
First time on Bsky and first big announcement!
I am excited to announce that our new study explaining the missing heritability of many phenotypes using WGS data from ~347,000 UK Biobank participants has just been published in @Nature.
Our manuscript is here: www.nature.com/articles/s41....
I am excited to announce that our new study explaining the missing heritability of many phenotypes using WGS data from ~347,000 UK Biobank participants has just been published in @Nature.
Our manuscript is here: www.nature.com/articles/s41....
Reposted by Abdel Abdellaoui
Late-life sexlessness is associated with higher education, lower alcohol and tobacco use, and a more nervous disposition, but around 15% of the variation is explained by thousands of genetic variants with tiny effects, research by @dr-appie.bsky.social et al finds:
buff.ly/5YTYf48
/1
buff.ly/5YTYf48
/1
November 9, 2025 at 5:35 PM
Late-life sexlessness is associated with higher education, lower alcohol and tobacco use, and a more nervous disposition, but around 15% of the variation is explained by thousands of genetic variants with tiny effects, research by @dr-appie.bsky.social et al finds:
buff.ly/5YTYf48
/1
buff.ly/5YTYf48
/1
Reposted by Abdel Abdellaoui
1/ 🚨New paper in Nature Genetics
Genetic factors are associated with the educational fields people study, from arts to engineering.
Article: www.nature.com/articles/s41...
FAQ: www.thehastingscenter.org/genomic-find...
Genetic factors are associated with the educational fields people study, from arts to engineering.
Article: www.nature.com/articles/s41...
FAQ: www.thehastingscenter.org/genomic-find...
Genetic associations with educational fields - Nature Genetics
Genome-wide analyses of 10 educational fields identify 17 associated loci. Analysis of genetic clustering across specializations identifies two key dimensions that show genetic overlap with personalit...
www.nature.com
November 4, 2025 at 10:23 AM
1/ 🚨New paper in Nature Genetics
Genetic factors are associated with the educational fields people study, from arts to engineering.
Article: www.nature.com/articles/s41...
FAQ: www.thehastingscenter.org/genomic-find...
Genetic factors are associated with the educational fields people study, from arts to engineering.
Article: www.nature.com/articles/s41...
FAQ: www.thehastingscenter.org/genomic-find...
Reposted by Abdel Abdellaoui
My house, @dr-appie.bsky.social’s house, @dirksmit.bsky.social’s house and the BGA 2026 venue are in this shot.. if you go to the conference I’ll pull up in my own boat and we’ll do boatrides!!
November 2, 2025 at 5:23 PM
My house, @dr-appie.bsky.social’s house, @dirksmit.bsky.social’s house and the BGA 2026 venue are in this shot.. if you go to the conference I’ll pull up in my own boat and we’ll do boatrides!!
Nice commentary by @fctropf.bsky.social reflecting on our study on not having sex: www.pnas.org/doi/10.1073/...
(for full study, see quoted tweet below)
(for full study, see quoted tweet below)
October 28, 2025 at 2:55 PM
Nice commentary by @fctropf.bsky.social reflecting on our study on not having sex: www.pnas.org/doi/10.1073/...
(for full study, see quoted tweet below)
(for full study, see quoted tweet below)
Reposted by Abdel Abdellaoui
A study of over 500,000 Brits and Australians finds that people who never have sex are more educated, less likely to use alcohol and smoke, more nervous, lonelier, and unhappier. Regions with high income inequality had more sexless residents. In PNAS: www.pnas.org/doi/abs/10.1...
October 6, 2025 at 3:15 PM
A study of over 500,000 Brits and Australians finds that people who never have sex are more educated, less likely to use alcohol and smoke, more nervous, lonelier, and unhappier. Regions with high income inequality had more sexless residents. In PNAS: www.pnas.org/doi/abs/10.1...
Reposted by Abdel Abdellaoui
🧬💥 Do the genetics that make you develop a disease also help you survive it? Not much.
Our new study in Nature Genetics including 9 disease and 7 biobanks shows:
• Susceptibility variants ≠ survival
• PRSs for onset weak at predicting progression
• Lifespan PRS predicts survival better
Our new study in Nature Genetics including 9 disease and 7 biobanks shows:
• Susceptibility variants ≠ survival
• PRSs for onset weak at predicting progression
• Lifespan PRS predicts survival better
September 30, 2025 at 12:50 PM
🧬💥 Do the genetics that make you develop a disease also help you survive it? Not much.
Our new study in Nature Genetics including 9 disease and 7 biobanks shows:
• Susceptibility variants ≠ survival
• PRSs for onset weak at predicting progression
• Lifespan PRS predicts survival better
Our new study in Nature Genetics including 9 disease and 7 biobanks shows:
• Susceptibility variants ≠ survival
• PRSs for onset weak at predicting progression
• Lifespan PRS predicts survival better
Reposted by Abdel Abdellaoui
#Sexlessness: Why do some people never have #sex, even later in life? A new study, conducted by @amsterdamumc.bsky.social and the University of Queensland alongside researchers of our Institute, explores this fascinating question.
Check out the @pnas.org paper here: doi.org/10.1073/pnas.2418257122
Check out the @pnas.org paper here: doi.org/10.1073/pnas.2418257122
September 22, 2025 at 10:06 AM
#Sexlessness: Why do some people never have #sex, even later in life? A new study, conducted by @amsterdamumc.bsky.social and the University of Queensland alongside researchers of our Institute, explores this fascinating question.
Check out the @pnas.org paper here: doi.org/10.1073/pnas.2418257122
Check out the @pnas.org paper here: doi.org/10.1073/pnas.2418257122
Reposted by Abdel Abdellaoui
Within-family heritability estimates for behavioural and disease phenotypes from 500,000 sibling pairs of diverse ancestries https://www.medrxiv.org/content/10.1101/2025.09.17.25336022v1
September 19, 2025 at 2:41 PM
Within-family heritability estimates for behavioural and disease phenotypes from 500,000 sibling pairs of diverse ancestries https://www.medrxiv.org/content/10.1101/2025.09.17.25336022v1
Reposted by Abdel Abdellaoui
Apply to do a PhD with me, Laura Corbin, Gareth Hawkes and George Davey Smith ( @mendelrandom.bsky.social) in Bristol on identifying rare effects on health using new and innovative methods. Amazing team, great educational environment, lovely city. Forward to your undergrads wrapping up!
Shining a light on the un-common to identify novel health risk-factors - GW4 BioMed MRC DTP
Project Code MRCPHS26Br Nivard Project Type Dry lab Research Theme Population Health Science Project Summary Download Summary Complex traits such as body mass index and height are influenced by a mixt...
gw4biomed.ac.uk
September 19, 2025 at 7:46 AM
Apply to do a PhD with me, Laura Corbin, Gareth Hawkes and George Davey Smith ( @mendelrandom.bsky.social) in Bristol on identifying rare effects on health using new and innovative methods. Amazing team, great educational environment, lovely city. Forward to your undergrads wrapping up!
Reposted by Abdel Abdellaoui
Loved hosting @essgn.bsky.social in Oxford including @dr-appie.bsky.social & family (& the rest of the ESSGN family as well) - read the post and links below to hear about this great event
September 17, 2025 at 7:52 PM
Loved hosting @essgn.bsky.social in Oxford including @dr-appie.bsky.social & family (& the rest of the ESSGN family as well) - read the post and links below to hear about this great event
Reposted by Abdel Abdellaoui
We welcomed the next generation of @essgn.bsky.social social science genomics researchers in Oxford!
✨ Speakers from industry (deCODE, Genomics), data (UKBiobank), experts from Oxford & beyond + an Editor from Nature Human Behaviour!
📸 More here 👉 www.demography.ox.ac.uk/news/lcds-ho...
✨ Speakers from industry (deCODE, Genomics), data (UKBiobank), experts from Oxford & beyond + an Editor from Nature Human Behaviour!
📸 More here 👉 www.demography.ox.ac.uk/news/lcds-ho...
September 17, 2025 at 7:44 PM
We welcomed the next generation of @essgn.bsky.social social science genomics researchers in Oxford!
✨ Speakers from industry (deCODE, Genomics), data (UKBiobank), experts from Oxford & beyond + an Editor from Nature Human Behaviour!
📸 More here 👉 www.demography.ox.ac.uk/news/lcds-ho...
✨ Speakers from industry (deCODE, Genomics), data (UKBiobank), experts from Oxford & beyond + an Editor from Nature Human Behaviour!
📸 More here 👉 www.demography.ox.ac.uk/news/lcds-ho...
Reposted by Abdel Abdellaoui
🔍 Behind the Paper: 'A Love Letter to Social Science Genetics'. 🧬 Some people call social science genetics a minefield. Others call it dangerous, even irresponsible. We call it the most promising field in life sciences. 🔗 bit.ly/46hwnBD @dr-appie.bsky.social @natureportfolio.nature.com #PsycSci
September 16, 2025 at 3:00 PM
🔍 Behind the Paper: 'A Love Letter to Social Science Genetics'. 🧬 Some people call social science genetics a minefield. Others call it dangerous, even irresponsible. We call it the most promising field in life sciences. 🔗 bit.ly/46hwnBD @dr-appie.bsky.social @natureportfolio.nature.com #PsycSci
The largest study on late life virginity, based on >400k individuals, out now in @pnas.org
Open access link: pnas.org/doi/10.1073/...
Shoutout to shared first author @laurawesseldijk.bsky.social ❤️
Thread below 👇🏽
Open access link: pnas.org/doi/10.1073/...
Shoutout to shared first author @laurawesseldijk.bsky.social ❤️
Thread below 👇🏽
September 16, 2025 at 8:26 PM
The largest study on late life virginity, based on >400k individuals, out now in @pnas.org
Open access link: pnas.org/doi/10.1073/...
Shoutout to shared first author @laurawesseldijk.bsky.social ❤️
Thread below 👇🏽
Open access link: pnas.org/doi/10.1073/...
Shoutout to shared first author @laurawesseldijk.bsky.social ❤️
Thread below 👇🏽
Reposted by Abdel Abdellaoui
"Social science genetics encompasses the longest causal chain in science: from DNA to human culture."
Some people call it a minefield. Others call it dangerous, even irresponsible. I call it the most promising field in life sciences.
My love letter to social science genetics: communities.springernature.com/posts/a-love...
My love letter to social science genetics: communities.springernature.com/posts/a-love...
A Love Letter to Social Science Genetics
Some people call social science genetics a minefield. Others call it dangerous, even irresponsible. I call it the most promising field in life sciences.
communities.springernature.com
September 9, 2025 at 7:11 PM
"Social science genetics encompasses the longest causal chain in science: from DNA to human culture."
Reposted by Abdel Abdellaoui
A great read👇
Some social science genetics papers are among the most interesting and methodologically rigorous I've read.
From biology to mating choices and inequalities, they deal with very fundamental concepts of what makes as humans.
Some social science genetics papers are among the most interesting and methodologically rigorous I've read.
From biology to mating choices and inequalities, they deal with very fundamental concepts of what makes as humans.
Some people call it a minefield. Others call it dangerous, even irresponsible. I call it the most promising field in life sciences.
My love letter to social science genetics: communities.springernature.com/posts/a-love...
My love letter to social science genetics: communities.springernature.com/posts/a-love...
A Love Letter to Social Science Genetics
Some people call social science genetics a minefield. Others call it dangerous, even irresponsible. I call it the most promising field in life sciences.
communities.springernature.com
September 11, 2025 at 9:09 PM
A great read👇
Some social science genetics papers are among the most interesting and methodologically rigorous I've read.
From biology to mating choices and inequalities, they deal with very fundamental concepts of what makes as humans.
Some social science genetics papers are among the most interesting and methodologically rigorous I've read.
From biology to mating choices and inequalities, they deal with very fundamental concepts of what makes as humans.
Reposted by Abdel Abdellaoui
A Love Letter to Social Science Genetics communities.springernature.com/posts/a-love...
A Love Letter to Social Science Genetics
Some people call social science genetics a minefield. Others call it dangerous, even irresponsible. I call it the most promising field in life sciences.
communities.springernature.com
September 9, 2025 at 9:18 AM
A Love Letter to Social Science Genetics communities.springernature.com/posts/a-love...
Reposted by Abdel Abdellaoui
"Part of maturing as a field is to recognize its history: to decide what to keep, & what we must outgrow, both in how we train the next generation of researchers & in how we help the public make sense of our past." @dr-appie.bsky.social's nuanced take on social science genetics, well worth a read.👇🧪
A Love Letter to Social Science Genetics
Some people call social science genetics a minefield. Others call it dangerous, even irresponsible. I call it the most promising field in life sciences.
communities.springernature.com
September 9, 2025 at 12:26 PM
"Part of maturing as a field is to recognize its history: to decide what to keep, & what we must outgrow, both in how we train the next generation of researchers & in how we help the public make sense of our past." @dr-appie.bsky.social's nuanced take on social science genetics, well worth a read.👇🧪
Reposted by Abdel Abdellaoui
It was an absolute joy to create visuals for Abdel and to see how these keep supporting his stories. I also appreciate social science genetics in a totally new way now 💙
Some people call it a minefield. Others call it dangerous, even irresponsible. I call it the most promising field in life sciences.
My love letter to social science genetics: communities.springernature.com/posts/a-love...
My love letter to social science genetics: communities.springernature.com/posts/a-love...
A Love Letter to Social Science Genetics
Some people call social science genetics a minefield. Others call it dangerous, even irresponsible. I call it the most promising field in life sciences.
communities.springernature.com
September 9, 2025 at 10:13 AM
It was an absolute joy to create visuals for Abdel and to see how these keep supporting his stories. I also appreciate social science genetics in a totally new way now 💙
Reposted by Abdel Abdellaoui
Thoughtful piece by Abdel on social science genetics - I am definitely taken by “one person’s confounder is another person’s signal”. Also humble about dark histories here and his own perspective
Some people call it a minefield. Others call it dangerous, even irresponsible. I call it the most promising field in life sciences.
My love letter to social science genetics: communities.springernature.com/posts/a-love...
My love letter to social science genetics: communities.springernature.com/posts/a-love...
A Love Letter to Social Science Genetics
Some people call social science genetics a minefield. Others call it dangerous, even irresponsible. I call it the most promising field in life sciences.
communities.springernature.com
September 9, 2025 at 7:33 AM
Thoughtful piece by Abdel on social science genetics - I am definitely taken by “one person’s confounder is another person’s signal”. Also humble about dark histories here and his own perspective
Reposted by Abdel Abdellaoui
Like reading my own thoughts...Thanks Abdel!
Some people call it a minefield. Others call it dangerous, even irresponsible. I call it the most promising field in life sciences.
My love letter to social science genetics: communities.springernature.com/posts/a-love...
My love letter to social science genetics: communities.springernature.com/posts/a-love...
A Love Letter to Social Science Genetics
Some people call social science genetics a minefield. Others call it dangerous, even irresponsible. I call it the most promising field in life sciences.
communities.springernature.com
September 9, 2025 at 7:26 AM
Like reading my own thoughts...Thanks Abdel!
Some people call it a minefield. Others call it dangerous, even irresponsible. I call it the most promising field in life sciences.
My love letter to social science genetics: communities.springernature.com/posts/a-love...
My love letter to social science genetics: communities.springernature.com/posts/a-love...
A Love Letter to Social Science Genetics
Some people call social science genetics a minefield. Others call it dangerous, even irresponsible. I call it the most promising field in life sciences.
communities.springernature.com
September 8, 2025 at 5:55 AM
Some people call it a minefield. Others call it dangerous, even irresponsible. I call it the most promising field in life sciences.
My love letter to social science genetics: communities.springernature.com/posts/a-love...
My love letter to social science genetics: communities.springernature.com/posts/a-love...