Djamel Nehar-Belaid
@dnehar.bsky.social
Passionate about #Immunology | Using Single cell multiomic approaches to understand immune aging and early life Immunity | The Jackson laboratory | https://dnehar.github.io/
Google scholar: https://scholar.google.fr/citations?user=zDjOYRUAAAAJ&hl=fr
Google scholar: https://scholar.google.fr/citations?user=zDjOYRUAAAAJ&hl=fr
7/10 In a combined analysis of infants and previously sequenced adults (generated by @tsanglab.bsky.social lab; PMID:33713619), infants display a similar ISG signature in monocytes but a markedly enhanced ISG signature in T and B cells, which is consistent with infant specific immune features.
May 16, 2025 at 6:00 PM
7/10 In a combined analysis of infants and previously sequenced adults (generated by @tsanglab.bsky.social lab; PMID:33713619), infants display a similar ISG signature in monocytes but a markedly enhanced ISG signature in T and B cells, which is consistent with infant specific immune features.
4/10 We described increased % of ISGhi CD16+ monocytes in infected infants, which differs from finding in adults, where CD16+ monocytes were contracted (PMID: 32810438). Also, infants with COVID-19 exhibited contraction of several DC subsets.
May 16, 2025 at 6:00 PM
4/10 We described increased % of ISGhi CD16+ monocytes in infected infants, which differs from finding in adults, where CD16+ monocytes were contracted (PMID: 32810438). Also, infants with COVID-19 exhibited contraction of several DC subsets.
3/10 We observed higher % of interferon-stimulated genes (ISG)hi CD14+ monocytes in infected infants than controls. Notably, ISGhi IL1B+ CD14+ mo were increased in infected infants, which is consistent with our previous observations in children with lupus (PMID:32747814 and PMID: 39378884).
May 16, 2025 at 6:00 PM
3/10 We observed higher % of interferon-stimulated genes (ISG)hi CD14+ monocytes in infected infants than controls. Notably, ISGhi IL1B+ CD14+ mo were increased in infected infants, which is consistent with our previous observations in children with lupus (PMID:32747814 and PMID: 39378884).
1/10 I am very excited to share our latest study, now out in @natcomms.nature.com. We applied a multidimensional approach to decipher the immune responses to SARS-CoV-2 infection in 2-month-old hospitalized infants. We analyzed: scRNA-of PBMCs, serum cytokines and antibody responses. rdcu.be/emkNa
May 16, 2025 at 6:00 PM
1/10 I am very excited to share our latest study, now out in @natcomms.nature.com. We applied a multidimensional approach to decipher the immune responses to SARS-CoV-2 infection in 2-month-old hospitalized infants. We analyzed: scRNA-of PBMCs, serum cytokines and antibody responses. rdcu.be/emkNa