David E Sanin
@davidesanin.bsky.social
Assistant Professor at Johns Hopkins University and macrophage enthusiast! | he/him 🏳️🌈
Opinions are my own!
https://linktr.ee/davidesanin
Opinions are my own!
https://linktr.ee/davidesanin
We also use this method to predict how Dictyostelium discoideum changes their mitochondrial biology to go from an amoeba to multi-cellular aggregates! (Mitochondrial function sensing dye on the right lights up when cells aggregate and mitochondria lower membrane potential).
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August 22, 2025 at 2:11 AM
We also use this method to predict how Dictyostelium discoideum changes their mitochondrial biology to go from an amoeba to multi-cellular aggregates! (Mitochondrial function sensing dye on the right lights up when cells aggregate and mitochondria lower membrane potential).
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For example, in these plasmacytoid DCs, the transcriptional shift we detect is because of type I IFN production!
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August 22, 2025 at 2:11 AM
For example, in these plasmacytoid DCs, the transcriptional shift we detect is because of type I IFN production!
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2️⃣ We examine how well missing data patterns explain gene expression and derive a score from this result.
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August 22, 2025 at 2:11 AM
2️⃣ We examine how well missing data patterns explain gene expression and derive a score from this result.
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An OAR (Observed At Random) score links co-expression patterns and gene expression. A high OAR score indicates a poor prediction (an interesting cell!).
Our method has 2 main steps:
1️⃣ We define a set of co-expression patterns based on zero-counts, which we call missing data patterns.
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Our method has 2 main steps:
1️⃣ We define a set of co-expression patterns based on zero-counts, which we call missing data patterns.
2/n
August 22, 2025 at 2:11 AM
An OAR (Observed At Random) score links co-expression patterns and gene expression. A high OAR score indicates a poor prediction (an interesting cell!).
Our method has 2 main steps:
1️⃣ We define a set of co-expression patterns based on zero-counts, which we call missing data patterns.
2/n
Our method has 2 main steps:
1️⃣ We define a set of co-expression patterns based on zero-counts, which we call missing data patterns.
2/n
Enjoying day one of #SACB2025! Amazing line up of speakers today!! Good reminder of the amazing communities of scientists using all kinds of tools and working towards helping patients with cancer!
February 11, 2025 at 2:39 AM
Enjoying day one of #SACB2025! Amazing line up of speakers today!! Good reminder of the amazing communities of scientists using all kinds of tools and working towards helping patients with cancer!
Celebrating Christmas with my lab!
December 13, 2024 at 10:05 PM
Celebrating Christmas with my lab!
Post a picture you took (no description) to bring some zen to the timeline
November 16, 2024 at 8:40 PM
Post a picture you took (no description) to bring some zen to the timeline