David Peede
@david-peede.bsky.social
Moonlighting as a human population geneticists in the Huerta-Sánchez Lab at Brown University, and aspiring speciation geneticists.
Reposted by David Peede
Delighted that our paper about the distribution of genomic spans of clades/edges in genealogies (ARGs), and using this for detecting inversions and other SVs (and other phenomena that cause local disruption of recombination) is out in MBE academic.oup.com/mbe/article/... (1/n)
The Length of Haplotype Blocks and Signals of Structural Variation in Reconstructed Genealogies
Abstract. Recent breakthroughs have enabled the accurate inference of large-scale genealogies. Through modelling the impact of recombination on the correla
academic.oup.com
October 3, 2025 at 9:54 AM
Delighted that our paper about the distribution of genomic spans of clades/edges in genealogies (ARGs), and using this for detecting inversions and other SVs (and other phenomena that cause local disruption of recombination) is out in MBE academic.oup.com/mbe/article/... (1/n)
Reposted by David Peede
Hybridization and introgression are major evolutionary processes. Since the 1940s, the prevailing view has been that they shape plants far more than animals. In our new study (www.science.org/doi/10.1126/...
), we find the opposite: animals exchange genes more, and for longer, than plants
), we find the opposite: animals exchange genes more, and for longer, than plants
September 12, 2025 at 7:55 AM
Hybridization and introgression are major evolutionary processes. Since the 1940s, the prevailing view has been that they shape plants far more than animals. In our new study (www.science.org/doi/10.1126/...
), we find the opposite: animals exchange genes more, and for longer, than plants
), we find the opposite: animals exchange genes more, and for longer, than plants
Reposted by David Peede
An extraordinary story of archaic introgression🧬: a Denisovan haplotype, introgressed through Neanderthals, selected in the Americas, and linked to an expanded copy number of a tandem repeat.
Congrats to @david-peede.bsky.social, Emilia, and the whole team!
👉 Enjoy the read: doi.org/10.1126/scie...
Congrats to @david-peede.bsky.social, Emilia, and the whole team!
👉 Enjoy the read: doi.org/10.1126/scie...
The MUC19 gene: An evolutionary history of recurrent introgression and natural selection
We study the gene MUC19, for which some modern humans carry a Denisovan-like haplotype. MUC19 is a mucin, a glycoprotein that forms gels with various biological functions. We find diagnostic variants ...
www.science.org
September 1, 2025 at 5:31 PM
An extraordinary story of archaic introgression🧬: a Denisovan haplotype, introgressed through Neanderthals, selected in the Americas, and linked to an expanded copy number of a tandem repeat.
Congrats to @david-peede.bsky.social, Emilia, and the whole team!
👉 Enjoy the read: doi.org/10.1126/scie...
Congrats to @david-peede.bsky.social, Emilia, and the whole team!
👉 Enjoy the read: doi.org/10.1126/scie...
Reposted by David Peede
I am so happy to see this fantastic study finally published! Huge congrats to @david-peede.bsky.social , @fervillanea.bsky.social , and all the co-authors. Amazing work! 😍
Our paper on the evolution of MUC19 in humans, Neanderthals, and Denisovans is finally out today in Science!
This has been a six-year effort by 13 authors to weave together 3 separate but related evolutionary stories around this one gene (more on thread 🧵).
www.science.org/doi/10.1126/...
This has been a six-year effort by 13 authors to weave together 3 separate but related evolutionary stories around this one gene (more on thread 🧵).
www.science.org/doi/10.1126/...
The MUC19 gene: An evolutionary history of recurrent introgression and natural selection
We study the gene MUC19, for which some modern humans carry a Denisovan-like haplotype. MUC19 is a mucin, a glycoprotein that forms gels with various biological functions. We find diagnostic variants ...
www.science.org
September 1, 2025 at 10:23 AM
I am so happy to see this fantastic study finally published! Huge congrats to @david-peede.bsky.social , @fervillanea.bsky.social , and all the co-authors. Amazing work! 😍
Reposted by David Peede
Thrilled to see this paper on MUC19 out. I feel honoured and priviledged to have witnessed this amazing project unfold. Read @fervillanea.bsky.social ’s thread and be prepared for a jaw-dropping story on introgression and selection, and best of all… in Native and Admixed Americans!!
Our paper on the evolution of MUC19 in humans, Neanderthals, and Denisovans is finally out today in Science!
This has been a six-year effort by 13 authors to weave together 3 separate but related evolutionary stories around this one gene (more on thread 🧵).
www.science.org/doi/10.1126/...
This has been a six-year effort by 13 authors to weave together 3 separate but related evolutionary stories around this one gene (more on thread 🧵).
www.science.org/doi/10.1126/...
The MUC19 gene: An evolutionary history of recurrent introgression and natural selection
We study the gene MUC19, for which some modern humans carry a Denisovan-like haplotype. MUC19 is a mucin, a glycoprotein that forms gels with various biological functions. We find diagnostic variants ...
www.science.org
August 22, 2025 at 5:35 AM
Thrilled to see this paper on MUC19 out. I feel honoured and priviledged to have witnessed this amazing project unfold. Read @fervillanea.bsky.social ’s thread and be prepared for a jaw-dropping story on introgression and selection, and best of all… in Native and Admixed Americans!!
Reposted by David Peede
Our paper on the evolution of MUC19 in humans, Neanderthals, and Denisovans is finally out today in Science!
This has been a six-year effort by 13 authors to weave together 3 separate but related evolutionary stories around this one gene (more on thread 🧵).
www.science.org/doi/10.1126/...
This has been a six-year effort by 13 authors to weave together 3 separate but related evolutionary stories around this one gene (more on thread 🧵).
www.science.org/doi/10.1126/...
The MUC19 gene: An evolutionary history of recurrent introgression and natural selection
We study the gene MUC19, for which some modern humans carry a Denisovan-like haplotype. MUC19 is a mucin, a glycoprotein that forms gels with various biological functions. We find diagnostic variants ...
www.science.org
August 21, 2025 at 7:36 PM
Our paper on the evolution of MUC19 in humans, Neanderthals, and Denisovans is finally out today in Science!
This has been a six-year effort by 13 authors to weave together 3 separate but related evolutionary stories around this one gene (more on thread 🧵).
www.science.org/doi/10.1126/...
This has been a six-year effort by 13 authors to weave together 3 separate but related evolutionary stories around this one gene (more on thread 🧵).
www.science.org/doi/10.1126/...
Reposted by David Peede
@david-peede.bsky.social et al on the convoluted route of a variant of the MUC19 gene: Denisovans (before going extinct) passed the gene to Neanderthals, who (before going extinct) passed it to ancient humans, who then crossed the Bering Strait. Today, 1 in 3 Mexicans carry the genetic variant.
August 21, 2025 at 7:05 PM
@david-peede.bsky.social et al on the convoluted route of a variant of the MUC19 gene: Denisovans (before going extinct) passed the gene to Neanderthals, who (before going extinct) passed it to ancient humans, who then crossed the Bering Strait. Today, 1 in 3 Mexicans carry the genetic variant.
It’s UNREAL 🤯 what imputation can reveal about archaic Introgression across space 🌎 and time ⏳, and I'm personally STOKED 🤩 to see what the imputation era of archaic introgression will uncover 👀
Turns out imputation of introgressed archaic regions in aDNA works really well — sometimes even better than for the rest of the genome. More on this (and other cool results) in our new preprint 👇 #aDNA #ArchaicIntrogression #imputation
doi.org/10.1101/2025...
doi.org/10.1101/2025...
Archaic ancestry inference in imputed ancient human genomes
When modern humans expanded from Africa into Eurasia, they interbred with archaic hominins such as Neanderthals and Denisovans. This groundbreaking discovery, made in part possible through the genomic...
doi.org
July 24, 2025 at 4:17 PM
It’s UNREAL 🤯 what imputation can reveal about archaic Introgression across space 🌎 and time ⏳, and I'm personally STOKED 🤩 to see what the imputation era of archaic introgression will uncover 👀
Reposted by David Peede
Congratulations to this year's Hamilton Award finalists! 🎉 Join us Thursday, May 29 to hear these outstanding student talks. See the full schedule on the meeting website: www.evolutionmeetings.org/program-over... @evolmtg.bsky.social
May 22, 2025 at 7:22 AM
Congratulations to this year's Hamilton Award finalists! 🎉 Join us Thursday, May 29 to hear these outstanding student talks. See the full schedule on the meeting website: www.evolutionmeetings.org/program-over... @evolmtg.bsky.social