Jonas Möcking
@cryonas.bsky.social
Marie Curie Postdoc Fellow at Utrecht University 🇳🇱 Protein-Biochemist diving into cryo-ET ❄️
Using subtomogram averaging we further determine the structure of the SUN5 LINC lattice and propose a model in which the lattice, formed by SUN5 trimers, reinforces the head-tail junction. This model could also explain SUN5's role in ASS. Full story here: www.biorxiv.org/content/10.1... 3/4
SUN5 forms a regular protein lattice reinforcing the sperm head-tail junction
Linker of nucleo- and cytoskeleton (LINC) complexes reside in the nuclear envelope, the double-membrane surrounding the nucleus, where they establish a physical bridge between nucleus and cytoplasm. L...
www.biorxiv.org
July 31, 2025 at 3:40 PM
Using subtomogram averaging we further determine the structure of the SUN5 LINC lattice and propose a model in which the lattice, formed by SUN5 trimers, reinforces the head-tail junction. This model could also explain SUN5's role in ASS. Full story here: www.biorxiv.org/content/10.1... 3/4
SUN5 is part of LINC (linker of nucleo- and cytoskeleton) complexes, which do exactly what their name suggests: physically link🔗 the nuclear lamina with the cytoskeleton via the NE. Specifically staining for SUN5, we confirm its localization to the posterior sperm head by fluorescence microscopy.2/4
July 31, 2025 at 3:40 PM
SUN5 is part of LINC (linker of nucleo- and cytoskeleton) complexes, which do exactly what their name suggests: physically link🔗 the nuclear lamina with the cytoskeleton via the NE. Specifically staining for SUN5, we confirm its localization to the posterior sperm head by fluorescence microscopy.2/4