Coleman Lab
@colemanlab.bsky.social
Doing great science by putting people first Neuroscience group protecting axons sciencewithoutanguish.com
Fellow of Churchill College, Cambridge
Coach supporting scientists to get more clarity on their goals and move toward them
Fellow of Churchill College, Cambridge
Coach supporting scientists to get more clarity on their goals and move toward them
Today in Science Without Anguish: how failing to notice when the wind is behind us makes us believe the world is against us when things don’t go our way.
www.sciencewithoutanguish.com/blog/im-good...
www.sciencewithoutanguish.com/blog/im-good...
November 3, 2025 at 9:02 PM
Today in Science Without Anguish: how failing to notice when the wind is behind us makes us believe the world is against us when things don’t go our way.
www.sciencewithoutanguish.com/blog/im-good...
www.sciencewithoutanguish.com/blog/im-good...
Science Without Anguish series 3
This week: the mistakes we make understanding our world that we would never make in our science
www.sciencewithoutanguish.com/blog/heurist...
Coming up next week: how what grabs our attention most and first impressions skew our thinking.
This week: the mistakes we make understanding our world that we would never make in our science
www.sciencewithoutanguish.com/blog/heurist...
Coming up next week: how what grabs our attention most and first impressions skew our thinking.
October 13, 2025 at 8:11 PM
Science Without Anguish series 3
This week: the mistakes we make understanding our world that we would never make in our science
www.sciencewithoutanguish.com/blog/heurist...
Coming up next week: how what grabs our attention most and first impressions skew our thinking.
This week: the mistakes we make understanding our world that we would never make in our science
www.sciencewithoutanguish.com/blog/heurist...
Coming up next week: how what grabs our attention most and first impressions skew our thinking.
This week in Science Without Anguish: how simplifying our view of the world based on limited evidence can lead us astray. www.sciencewithoutanguish.com/blog/heurist...
October 6, 2025 at 8:45 PM
This week in Science Without Anguish: how simplifying our view of the world based on limited evidence can lead us astray. www.sciencewithoutanguish.com/blog/heurist...
Science Without Anguish series 3: out now!
www.sciencewithoutanguish.com/blog/dont-be...
Could clear thinking about research life make it easier?
Next week: The short cuts our minds use to make sense of the world and the problems this can lead to.
www.sciencewithoutanguish.com/blog/dont-be...
Could clear thinking about research life make it easier?
Next week: The short cuts our minds use to make sense of the world and the problems this can lead to.
September 29, 2025 at 5:26 PM
Science Without Anguish series 3: out now!
www.sciencewithoutanguish.com/blog/dont-be...
Could clear thinking about research life make it easier?
Next week: The short cuts our minds use to make sense of the world and the problems this can lead to.
www.sciencewithoutanguish.com/blog/dont-be...
Could clear thinking about research life make it easier?
Next week: The short cuts our minds use to make sense of the world and the problems this can lead to.
Science Without Anguish Series 3 in out:
Don’t believe everything you think!
Confusing our mental shortcuts with reality.
Excusing ourselves but blaming others.
Not realising we’re doing it and making life harder for ourselves in the process.
www.sciencewithoutanguish.com/blog/dont-be...
Don’t believe everything you think!
Confusing our mental shortcuts with reality.
Excusing ourselves but blaming others.
Not realising we’re doing it and making life harder for ourselves in the process.
www.sciencewithoutanguish.com/blog/dont-be...
September 22, 2025 at 8:15 PM
Science Without Anguish Series 3 in out:
Don’t believe everything you think!
Confusing our mental shortcuts with reality.
Excusing ourselves but blaming others.
Not realising we’re doing it and making life harder for ourselves in the process.
www.sciencewithoutanguish.com/blog/dont-be...
Don’t believe everything you think!
Confusing our mental shortcuts with reality.
Excusing ourselves but blaming others.
Not realising we’re doing it and making life harder for ourselves in the process.
www.sciencewithoutanguish.com/blog/dont-be...
How much of what we think we ‘know’ is just trust in the person that told us?
And what price do we pay for confusing the two?
Coming soon in Science Without Anguish:
‘Don’t believe everything you think!’
sciencewithoutanguish.com
Starts Monday 22nd Sep
And what price do we pay for confusing the two?
Coming soon in Science Without Anguish:
‘Don’t believe everything you think!’
sciencewithoutanguish.com
Starts Monday 22nd Sep
September 20, 2025 at 1:24 PM
How much of what we think we ‘know’ is just trust in the person that told us?
And what price do we pay for confusing the two?
Coming soon in Science Without Anguish:
‘Don’t believe everything you think!’
sciencewithoutanguish.com
Starts Monday 22nd Sep
And what price do we pay for confusing the two?
Coming soon in Science Without Anguish:
‘Don’t believe everything you think!’
sciencewithoutanguish.com
Starts Monday 22nd Sep
Science Without Anguish Series 3 starts Monday 22nd
'Don't believe everything you think!'.
sciencewithoutanguish.com
How heuristics & biases make our research lives more difficult and ways to reduce this. Stereotyping, snap judgements, confirmation bias, attribution errors, negativity bias….
'Don't believe everything you think!'.
sciencewithoutanguish.com
How heuristics & biases make our research lives more difficult and ways to reduce this. Stereotyping, snap judgements, confirmation bias, attribution errors, negativity bias….
September 18, 2025 at 10:49 AM
Science Without Anguish Series 3 starts Monday 22nd
'Don't believe everything you think!'.
sciencewithoutanguish.com
How heuristics & biases make our research lives more difficult and ways to reduce this. Stereotyping, snap judgements, confirmation bias, attribution errors, negativity bias….
'Don't believe everything you think!'.
sciencewithoutanguish.com
How heuristics & biases make our research lives more difficult and ways to reduce this. Stereotyping, snap judgements, confirmation bias, attribution errors, negativity bias….
This week in Science Without Anguish:
Loneliness and the long distance researcher. Overcoming isolation for science and wellbeing.
www.sciencewithoutanguish.com/blog/overcom...
This is the last post in Series 2. Stay tuned for webinar announcements, plans for a coaching programme and Series 3.
Loneliness and the long distance researcher. Overcoming isolation for science and wellbeing.
www.sciencewithoutanguish.com/blog/overcom...
This is the last post in Series 2. Stay tuned for webinar announcements, plans for a coaching programme and Series 3.
December 2, 2024 at 5:32 PM
This week in Science Without Anguish:
Loneliness and the long distance researcher. Overcoming isolation for science and wellbeing.
www.sciencewithoutanguish.com/blog/overcom...
This is the last post in Series 2. Stay tuned for webinar announcements, plans for a coaching programme and Series 3.
Loneliness and the long distance researcher. Overcoming isolation for science and wellbeing.
www.sciencewithoutanguish.com/blog/overcom...
This is the last post in Series 2. Stay tuned for webinar announcements, plans for a coaching programme and Series 3.
November 28, 2024 at 1:45 PM
Who is driving the bus in your research career: you, your emotions or other people?
www.sciencewithoutanguish.com/blog/who-is-...
www.sciencewithoutanguish.com/blog/who-is-...
November 28, 2024 at 10:19 AM
Who is driving the bus in your research career: you, your emotions or other people?
www.sciencewithoutanguish.com/blog/who-is-...
www.sciencewithoutanguish.com/blog/who-is-...
This week in Science Without Anguish: Who is driving our bus? The importance of controlling the controllables in research life.
www.sciencewithoutanguish.com/blog/who-is-...
www.sciencewithoutanguish.com/blog/who-is-...
November 25, 2024 at 12:37 PM
This week in Science Without Anguish: Who is driving our bus? The importance of controlling the controllables in research life.
www.sciencewithoutanguish.com/blog/who-is-...
www.sciencewithoutanguish.com/blog/who-is-...
Summary:
(1) Baseline axonal SARM1 NADase activity may differ between people due to NMNAT2 differences
(2) This may confer risk of miscarriage and neurological disorders
(3) NR is safe in most people but there is some need for caution
link.springer.com/article/10.1...
Congratulations, Christina!
(1) Baseline axonal SARM1 NADase activity may differ between people due to NMNAT2 differences
(2) This may confer risk of miscarriage and neurological disorders
(3) NR is safe in most people but there is some need for caution
link.springer.com/article/10.1...
Congratulations, Christina!
November 24, 2024 at 12:18 PM
Summary:
(1) Baseline axonal SARM1 NADase activity may differ between people due to NMNAT2 differences
(2) This may confer risk of miscarriage and neurological disorders
(3) NR is safe in most people but there is some need for caution
link.springer.com/article/10.1...
Congratulations, Christina!
(1) Baseline axonal SARM1 NADase activity may differ between people due to NMNAT2 differences
(2) This may confer risk of miscarriage and neurological disorders
(3) NR is safe in most people but there is some need for caution
link.springer.com/article/10.1...
Congratulations, Christina!
(6) NAD precursor nicotinamide riboside (NR) increases NAD in wild-type neurons and in the soma or neurons with insufficient NMNAT2 (probably because they also have NMNAT1).
(7) But in sympathetic neuron axons from low-NMNAT2 mice, NR significantly LOWERS NAD in a SARM1-dependent manner.
(7) But in sympathetic neuron axons from low-NMNAT2 mice, NR significantly LOWERS NAD in a SARM1-dependent manner.
November 24, 2024 at 12:18 PM
(6) NAD precursor nicotinamide riboside (NR) increases NAD in wild-type neurons and in the soma or neurons with insufficient NMNAT2 (probably because they also have NMNAT1).
(7) But in sympathetic neuron axons from low-NMNAT2 mice, NR significantly LOWERS NAD in a SARM1-dependent manner.
(7) But in sympathetic neuron axons from low-NMNAT2 mice, NR significantly LOWERS NAD in a SARM1-dependent manner.
'Skeetorial' of our latest paper: link.springer.com/article/10.1...
So proud of first author Christina Antoniou for this, now a postdoc with @melissa-gammons1.bsky.social.
(1) NMNAT2 is a repressor of SARM1 NADase in axons. A few people have NMNAT2 LoF mutations. Many more have low expression.
So proud of first author Christina Antoniou for this, now a postdoc with @melissa-gammons1.bsky.social.
(1) NMNAT2 is a repressor of SARM1 NADase in axons. A few people have NMNAT2 LoF mutations. Many more have low expression.
November 24, 2024 at 12:18 PM
'Skeetorial' of our latest paper: link.springer.com/article/10.1...
So proud of first author Christina Antoniou for this, now a postdoc with @melissa-gammons1.bsky.social.
(1) NMNAT2 is a repressor of SARM1 NADase in axons. A few people have NMNAT2 LoF mutations. Many more have low expression.
So proud of first author Christina Antoniou for this, now a postdoc with @melissa-gammons1.bsky.social.
(1) NMNAT2 is a repressor of SARM1 NADase in axons. A few people have NMNAT2 LoF mutations. Many more have low expression.
If you liked the sciencewithoutanguish.com on imposter syndrome, see previous posts including:
- 'If you're overwhelmed, you're normal'
- 'What's luck got to do with it?'
- 'Success is a menu, not a recipe'
- 'The high cost of fear in research'.
Plus option to hear of new posts by email
- 'If you're overwhelmed, you're normal'
- 'What's luck got to do with it?'
- 'Success is a menu, not a recipe'
- 'The high cost of fear in research'.
Plus option to hear of new posts by email
November 21, 2024 at 10:34 AM
If you liked the sciencewithoutanguish.com on imposter syndrome, see previous posts including:
- 'If you're overwhelmed, you're normal'
- 'What's luck got to do with it?'
- 'Success is a menu, not a recipe'
- 'The high cost of fear in research'.
Plus option to hear of new posts by email
- 'If you're overwhelmed, you're normal'
- 'What's luck got to do with it?'
- 'Success is a menu, not a recipe'
- 'The high cost of fear in research'.
Plus option to hear of new posts by email
This week’s Science Without Anguish post is out: the slippery slope to imposter syndrome in research and how to escape it.
Please tell your colleagues on or off social media. 🧪
www.sciencewithoutanguish.com/blog/we-are-...
Please tell your colleagues on or off social media. 🧪
www.sciencewithoutanguish.com/blog/we-are-...
November 18, 2024 at 6:07 PM
This week’s Science Without Anguish post is out: the slippery slope to imposter syndrome in research and how to escape it.
Please tell your colleagues on or off social media. 🧪
www.sciencewithoutanguish.com/blog/we-are-...
Please tell your colleagues on or off social media. 🧪
www.sciencewithoutanguish.com/blog/we-are-...
Completely agree @drsimoncook.bsky.social. It sums up exactly why we need to do and communicate science more than ever now.
www.sciencewithoutanguish.com/blog/healing...
www.sciencewithoutanguish.com/blog/healing...
November 17, 2024 at 6:16 PM
Completely agree @drsimoncook.bsky.social. It sums up exactly why we need to do and communicate science more than ever now.
www.sciencewithoutanguish.com/blog/healing...
www.sciencewithoutanguish.com/blog/healing...
What is the future for science in a world of ‘alternative facts’?
www.sciencewithoutanguish.com/blog/healing...
www.sciencewithoutanguish.com/blog/healing...
November 15, 2024 at 6:59 AM
What is the future for science in a world of ‘alternative facts’?
www.sciencewithoutanguish.com/blog/healing...
www.sciencewithoutanguish.com/blog/healing...
In the meantime, a quick reminder of the topical Science Without Anguish blog post this week. www.sciencewithoutanguish.com
November 13, 2024 at 11:58 PM
In the meantime, a quick reminder of the topical Science Without Anguish blog post this week. www.sciencewithoutanguish.com
What does the apparent success of arrogance, threats and an obsession with money mean for how we do scientific research?
Time for a long, hard look at values, purpose and what we want research culture to be
This week in ‘Science Without Anguish’:🧪
www.sciencewithoutanguish.com/blog/healing...
Time for a long, hard look at values, purpose and what we want research culture to be
This week in ‘Science Without Anguish’:🧪
www.sciencewithoutanguish.com/blog/healing...
November 13, 2024 at 12:32 AM
What does the apparent success of arrogance, threats and an obsession with money mean for how we do scientific research?
Time for a long, hard look at values, purpose and what we want research culture to be
This week in ‘Science Without Anguish’:🧪
www.sciencewithoutanguish.com/blog/healing...
Time for a long, hard look at values, purpose and what we want research culture to be
This week in ‘Science Without Anguish’:🧪
www.sciencewithoutanguish.com/blog/healing...
This week’s Science Without Anguish again for joiners & anyone who missed it. 🧪
Healing the wounds to get back to research with new resolve and improved culture
Please share widely on & off social media. Reskeets are seen by others, likes are not!
www.sciencewithoutanguish.com/blog/healing...
Healing the wounds to get back to research with new resolve and improved culture
Please share widely on & off social media. Reskeets are seen by others, likes are not!
www.sciencewithoutanguish.com/blog/healing...
November 12, 2024 at 11:39 AM
This week’s Science Without Anguish again for joiners & anyone who missed it. 🧪
Healing the wounds to get back to research with new resolve and improved culture
Please share widely on & off social media. Reskeets are seen by others, likes are not!
www.sciencewithoutanguish.com/blog/healing...
Healing the wounds to get back to research with new resolve and improved culture
Please share widely on & off social media. Reskeets are seen by others, likes are not!
www.sciencewithoutanguish.com/blog/healing...
Good evening America. We know you’re hurting. So are we. We know every scientist joining BlueSky right now is joining for similar reasons. So did we.
If you’re struggling to get back to research🧪 right now, wondering why you even bother, this may help.
www.sciencewithoutanguish.com
If you’re struggling to get back to research🧪 right now, wondering why you even bother, this may help.
www.sciencewithoutanguish.com
November 11, 2024 at 11:47 PM
Good evening America. We know you’re hurting. So are we. We know every scientist joining BlueSky right now is joining for similar reasons. So did we.
If you’re struggling to get back to research🧪 right now, wondering why you even bother, this may help.
www.sciencewithoutanguish.com
If you’re struggling to get back to research🧪 right now, wondering why you even bother, this may help.
www.sciencewithoutanguish.com
Hey folks, 2 engagements on this post over here vs 14 on the ‘bad’ site. The blog speaks to exactly the reason so many of us are joining so if you find it useful let’s ramp it up!! Remember likes don’t show up in other people’s feeds, only reskeets do! www.sciencewithoutanguish.com/blog/healing...
November 11, 2024 at 6:59 PM
Hey folks, 2 engagements on this post over here vs 14 on the ‘bad’ site. The blog speaks to exactly the reason so many of us are joining so if you find it useful let’s ramp it up!! Remember likes don’t show up in other people’s feeds, only reskeets do! www.sciencewithoutanguish.com/blog/healing...
If your world feels ripped apart and research seems suddenly pointless, see this week’s Science Without Anguish post! 🧪
‘Healing the wounds: why science and research culture matter more than ever now’
www.sciencewithoutanguish.com/blog/healing...
Please tell colleagues, on or off social media.
‘Healing the wounds: why science and research culture matter more than ever now’
www.sciencewithoutanguish.com/blog/healing...
Please tell colleagues, on or off social media.
November 11, 2024 at 4:45 PM
If your world feels ripped apart and research seems suddenly pointless, see this week’s Science Without Anguish post! 🧪
‘Healing the wounds: why science and research culture matter more than ever now’
www.sciencewithoutanguish.com/blog/healing...
Please tell colleagues, on or off social media.
‘Healing the wounds: why science and research culture matter more than ever now’
www.sciencewithoutanguish.com/blog/healing...
Please tell colleagues, on or off social media.
Testing how feeds work.
And telling new scientists about ‘Science Without Anguish’. www.sciencewithoutanguish.com Managing overwhelm in research life, defining success, psychological safety and more. Next post Monday: getting back to calm and rational after major world events. Kind of topical! 🥶😎🧪
And telling new scientists about ‘Science Without Anguish’. www.sciencewithoutanguish.com Managing overwhelm in research life, defining success, psychological safety and more. Next post Monday: getting back to calm and rational after major world events. Kind of topical! 🥶😎🧪
November 8, 2024 at 9:47 PM
Testing how feeds work.
And telling new scientists about ‘Science Without Anguish’. www.sciencewithoutanguish.com Managing overwhelm in research life, defining success, psychological safety and more. Next post Monday: getting back to calm and rational after major world events. Kind of topical! 🥶😎🧪
And telling new scientists about ‘Science Without Anguish’. www.sciencewithoutanguish.com Managing overwhelm in research life, defining success, psychological safety and more. Next post Monday: getting back to calm and rational after major world events. Kind of topical! 🥶😎🧪