Thank you. It was fantastic to read your discussion on this topic.

Thank you Carlos!

9/9 This work would also not have been possible without the funding of @lundbeckfonden.bsky.social, Novo Nordisk Foundation and the Copenhagen Bioscience PhD Programme to whom I'm grateful for the support 🙌

8/9 This milestone results from my work during the PhD but also from the incredible support and collaboration of the co-authors, @lundjens.bsky.social, @jzylicz.bsky.social, @pranea.bsky.social, Thorkild Sørensen, @clemmensenc.bsky.social and my amazing colleagues from @cbmr.science @koebenhavns_u

7/9 With this work, we underline the role of food insecurity as a promotor of energy storage in adipose tissue, highlighting the importance of addressing the roots of obesity in populations with a limited access to nutritious foods 🍎🥗

6/9 To dissect the biological mechanisms behind this response, we looked into the adipose tissue transcriptional signature driven by food insecurity in male lean mice, unveiling potential mechanisms of lipid regulation under food insecurity situations 🧬

5/9 Surprisingly, a significant reduction in lean mass was also observed in male mice exposed to high-fat diet, even with the pronounced positive energy balance with this type of diet 🤯

4/9 After a 4-week exposure to food insecurity, and despite the maintenance of body weight, male and female mice increased their fat reserves 📈, while their lean mass was reduced 📉

3/9 To understand how food insecurity could be a driver of increased adiposity, we developed a novel mouse model of food insecurity, by exposing C57BL/6J mice to an intermittent access to standard food 🐭🧀

2/9 Intrigued by the high prevalence of obesity in food-insecure populations, and the evolutionary rationale behind the insurance hypothesis (doi.org/10.1017/S014...), we started thinking of a way of modelling food insecurity in mice to further explore this association.