CIRTN-R2FIC
@cirtn.bsky.social
We are the Canadian Islet Research and Training Network / Réseau de researche et formation sur les îlots du Canada.
Find out more at Islets.ca
Note: Account is primarily run by the volunteer trainee committee.
Find out more at Islets.ca
Note: Account is primarily run by the volunteer trainee committee.
A bit about "Islets in a Pod": our series is meant to better introduce the CIRTN-R2FIC network, the PIs and the trainees. We also aim to continue promoting camaraderie amongst the members.
More interviews to come from both PIs and trainees that were at the Annual Meeting!
More interviews to come from both PIs and trainees that were at the Annual Meeting!
November 25, 2025 at 4:01 PM
A bit about "Islets in a Pod": our series is meant to better introduce the CIRTN-R2FIC network, the PIs and the trainees. We also aim to continue promoting camaraderie amongst the members.
More interviews to come from both PIs and trainees that were at the Annual Meeting!
More interviews to come from both PIs and trainees that were at the Annual Meeting!
🧵(12/12) For the beginning of Nov 2025:
From Dr. Michael B. Wheeler
"Early Postpartum Glucose Tolerance Reclassification by Gestational Diabetes Subtype" PMID: 41212558
jamanetwork.com/journals/jam...
From Dr. Michael B. Wheeler
"Early Postpartum Glucose Tolerance Reclassification by Gestational Diabetes Subtype" PMID: 41212558
jamanetwork.com/journals/jam...
Early Postpartum Glucose Tolerance Reclassification by Gestational Diabetes Subtype
This cohort study evaluates whether different subtypes of gestational diabetes are associated with different prevalence rates for postpartum prediabetes.
jamanetwork.com
November 17, 2025 at 11:26 PM
🧵(12/12) For the beginning of Nov 2025:
From Dr. Michael B. Wheeler
"Early Postpartum Glucose Tolerance Reclassification by Gestational Diabetes Subtype" PMID: 41212558
jamanetwork.com/journals/jam...
From Dr. Michael B. Wheeler
"Early Postpartum Glucose Tolerance Reclassification by Gestational Diabetes Subtype" PMID: 41212558
jamanetwork.com/journals/jam...
🧵(11/12) For the beginning of Nov 2025:
From Dr. Guy Rutter
"Additive Effects of Dorzagliatin and Glucagon-Like Peptide-1 Receptor Agonism in a Novel Mouse Model of GCK-MODY and in Obese db/db Mice" PMID: 41196662
diabetesjournals.org/diabetes/art...
From Dr. Guy Rutter
"Additive Effects of Dorzagliatin and Glucagon-Like Peptide-1 Receptor Agonism in a Novel Mouse Model of GCK-MODY and in Obese db/db Mice" PMID: 41196662
diabetesjournals.org/diabetes/art...
Additive Effects of Dorzagliatin and Glucagon-Like Peptide-1 Receptor Agonism in a Novel Mouse Model of GCK-MODY and in Obese db/db Mice
Glucokinase (GK) catalyzes the key regulatory step in glucose-stimulated insulin secretion (GSIS). Correspondingly, hetero- and homozygous mutations in hum
diabetesjournals.org
November 17, 2025 at 11:26 PM
🧵(11/12) For the beginning of Nov 2025:
From Dr. Guy Rutter
"Additive Effects of Dorzagliatin and Glucagon-Like Peptide-1 Receptor Agonism in a Novel Mouse Model of GCK-MODY and in Obese db/db Mice" PMID: 41196662
diabetesjournals.org/diabetes/art...
From Dr. Guy Rutter
"Additive Effects of Dorzagliatin and Glucagon-Like Peptide-1 Receptor Agonism in a Novel Mouse Model of GCK-MODY and in Obese db/db Mice" PMID: 41196662
diabetesjournals.org/diabetes/art...
🧵(10/12) For the beginning of Nov 2025:
From Dr. Michael Riddell
"Continuous Glucose Monitoring Profiles in Elite-Level Professional European Football Players" PMID: 41237017
journals.sagepub.com/doi/10.1177/...
From Dr. Michael Riddell
"Continuous Glucose Monitoring Profiles in Elite-Level Professional European Football Players" PMID: 41237017
journals.sagepub.com/doi/10.1177/...
Sage Journals: Discover world-class research
Subscription and open access journals from Sage, the world's leading independent academic publisher.
journals.sagepub.com
November 17, 2025 at 11:26 PM
🧵(10/12) For the beginning of Nov 2025:
From Dr. Michael Riddell
"Continuous Glucose Monitoring Profiles in Elite-Level Professional European Football Players" PMID: 41237017
journals.sagepub.com/doi/10.1177/...
From Dr. Michael Riddell
"Continuous Glucose Monitoring Profiles in Elite-Level Professional European Football Players" PMID: 41237017
journals.sagepub.com/doi/10.1177/...
🧵(9/12) For the beginning of Nov 2025:
From Dr. Francis Lynn
"Transcriptional and temporal heterogeneity of developing α cells revealed by single-cell RNA sequencing" PMID 41242298
www.sciencedirect.com/science/arti...
From Dr. Francis Lynn
"Transcriptional and temporal heterogeneity of developing α cells revealed by single-cell RNA sequencing" PMID 41242298
www.sciencedirect.com/science/arti...
Transcriptional and temporal heterogeneity of developing α cells revealed by single-cell RNA sequencing
Glucagon (Gcg)-expressing pancreatic α cells play pivotal roles in maintaining glucose and amino acid homeostasis; however, the cellular heterogeneity…
www.sciencedirect.com
November 17, 2025 at 11:26 PM
🧵(9/12) For the beginning of Nov 2025:
From Dr. Francis Lynn
"Transcriptional and temporal heterogeneity of developing α cells revealed by single-cell RNA sequencing" PMID 41242298
www.sciencedirect.com/science/arti...
From Dr. Francis Lynn
"Transcriptional and temporal heterogeneity of developing α cells revealed by single-cell RNA sequencing" PMID 41242298
www.sciencedirect.com/science/arti...
🧵(8/12) For the beginning of Nov 2025:
From Dr. Megan K. Levings
"An ultrasensitive and modular platform to detect Siglec ligands and control immune cell function" PMID 41223255
www.science.org/doi/10.1126/...
From Dr. Megan K. Levings
"An ultrasensitive and modular platform to detect Siglec ligands and control immune cell function" PMID 41223255
www.science.org/doi/10.1126/...
An ultrasensitive and modular platform to detect Siglec ligands and control immune cell function
Siglec-liposomes are a multivalent and modular platform for profiling Siglec ligands and modulating immune cell function.
www.science.org
November 17, 2025 at 11:26 PM
🧵(8/12) For the beginning of Nov 2025:
From Dr. Megan K. Levings
"An ultrasensitive and modular platform to detect Siglec ligands and control immune cell function" PMID 41223255
www.science.org/doi/10.1126/...
From Dr. Megan K. Levings
"An ultrasensitive and modular platform to detect Siglec ligands and control immune cell function" PMID 41223255
www.science.org/doi/10.1126/...
🧵(7/12) For the beginning of Nov 2025:
From Dr. Megan K. Levings
"Label-free estimation of regulatory T cell activation markers using Raman spectroscopy with machine learning" PMID: 41188301
www.nature.com/articles/s41...
From Dr. Megan K. Levings
"Label-free estimation of regulatory T cell activation markers using Raman spectroscopy with machine learning" PMID: 41188301
www.nature.com/articles/s41...
Label-free estimation of regulatory T cell activation markers using Raman spectroscopy with machine learning - Scientific Reports
Scientific Reports - Label-free estimation of regulatory T cell activation markers using Raman spectroscopy with machine learning
www.nature.com
November 17, 2025 at 11:26 PM
🧵(7/12) For the beginning of Nov 2025:
From Dr. Megan K. Levings
"Label-free estimation of regulatory T cell activation markers using Raman spectroscopy with machine learning" PMID: 41188301
www.nature.com/articles/s41...
From Dr. Megan K. Levings
"Label-free estimation of regulatory T cell activation markers using Raman spectroscopy with machine learning" PMID: 41188301
www.nature.com/articles/s41...
🧵(6/12) For the beginning of Nov 2025:
From Dr. Tatsuya Kin
"Benchmarking porcine pancreatic ductal organoids for drug screening applications" PMID: 41188536
www.embopress.org/doi/full/10....
From Dr. Tatsuya Kin
"Benchmarking porcine pancreatic ductal organoids for drug screening applications" PMID: 41188536
www.embopress.org/doi/full/10....
www.embopress.org
November 17, 2025 at 11:26 PM
🧵(6/12) For the beginning of Nov 2025:
From Dr. Tatsuya Kin
"Benchmarking porcine pancreatic ductal organoids for drug screening applications" PMID: 41188536
www.embopress.org/doi/full/10....
From Dr. Tatsuya Kin
"Benchmarking porcine pancreatic ductal organoids for drug screening applications" PMID: 41188536
www.embopress.org/doi/full/10....
🧵(5/12) For the beginning of Nov 2025:
From Dr. Corinne Hoesli
"An Accessible Platform to Quantify Oxygen Diffusion in Cell-Laden Hydrogels and Its Application to Alginate-Immobilized Pancreatic Beta Cells" PMID: 41220227
analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/...
From Dr. Corinne Hoesli
"An Accessible Platform to Quantify Oxygen Diffusion in Cell-Laden Hydrogels and Its Application to Alginate-Immobilized Pancreatic Beta Cells" PMID: 41220227
analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/...
An Accessible Platform to Quantify Oxygen Diffusion in Cell‐Laden Hydrogels and Its Application to Alginate‐Immobilized Pancreatic Beta Cells
A simple setup to measure oxygen diffusion coefficients was developed using equipment accessible to most wet laboratories. Gels that appeared softer and had lower loss moduli correlated with higher o...
analyticalsciencejournals.onlinelibrary.wiley.com
November 17, 2025 at 11:26 PM
🧵(5/12) For the beginning of Nov 2025:
From Dr. Corinne Hoesli
"An Accessible Platform to Quantify Oxygen Diffusion in Cell-Laden Hydrogels and Its Application to Alginate-Immobilized Pancreatic Beta Cells" PMID: 41220227
analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/...
From Dr. Corinne Hoesli
"An Accessible Platform to Quantify Oxygen Diffusion in Cell-Laden Hydrogels and Its Application to Alginate-Immobilized Pancreatic Beta Cells" PMID: 41220227
analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/...
🧵(4/12) For the beginning of Nov 2025:
From Dr. David Hill
"Pancreatic Cancer and Diabetes: Insights, Hypotheses, and Next Steps" PMID: 41226286
www.mdpi.com/1422-0067/26...
From Dr. David Hill
"Pancreatic Cancer and Diabetes: Insights, Hypotheses, and Next Steps" PMID: 41226286
www.mdpi.com/1422-0067/26...
www.mdpi.com
November 17, 2025 at 11:26 PM
🧵(4/12) For the beginning of Nov 2025:
From Dr. David Hill
"Pancreatic Cancer and Diabetes: Insights, Hypotheses, and Next Steps" PMID: 41226286
www.mdpi.com/1422-0067/26...
From Dr. David Hill
"Pancreatic Cancer and Diabetes: Insights, Hypotheses, and Next Steps" PMID: 41226286
www.mdpi.com/1422-0067/26...
🧵(3/12) For the beginning of Nov 2025:
From Dr. Savita Dhanvantari
"Glucagon, the Alpha Cell, and Potential Targets for Diabetes Treatment" PMID: 41206016
academic.oup.com/endo/advance...
From Dr. Savita Dhanvantari
"Glucagon, the Alpha Cell, and Potential Targets for Diabetes Treatment" PMID: 41206016
academic.oup.com/endo/advance...
Glucagon, the Alpha Cell, and Potential Targets for Diabetes Treatment
Abstract. Glucagon is a 29-amino acid hormone synthesized and secreted by the pancreatic alpha cell in the islets of Langerhans. It is the primary glucose
academic.oup.com
November 17, 2025 at 11:26 PM
🧵(3/12) For the beginning of Nov 2025:
From Dr. Savita Dhanvantari
"Glucagon, the Alpha Cell, and Potential Targets for Diabetes Treatment" PMID: 41206016
academic.oup.com/endo/advance...
From Dr. Savita Dhanvantari
"Glucagon, the Alpha Cell, and Potential Targets for Diabetes Treatment" PMID: 41206016
academic.oup.com/endo/advance...
🧵(2/12) For the beginning of Nov 2025:
From Drs Peter Thompson, Bruce Verchere and Yi-Chun Chen
"Insulin production is sustained during DNA damage-mediated senescence in adult human beta cells" • PMID: 41231256
link.springer.com/article/10.1...
From Drs Peter Thompson, Bruce Verchere and Yi-Chun Chen
"Insulin production is sustained during DNA damage-mediated senescence in adult human beta cells" • PMID: 41231256
link.springer.com/article/10.1...
Insulin production is sustained during DNA damage-mediated senescence in adult human beta cells - Diabetologia
Aims/hypothesis Residual pancreatic beta cells in type 1 diabetes show reduced insulin production but the mechanisms remain unclear. Beta cells undergo stress responses during type 1 diabetes, includi...
link.springer.com
November 17, 2025 at 11:26 PM
🧵(2/12) For the beginning of Nov 2025:
From Drs Peter Thompson, Bruce Verchere and Yi-Chun Chen
"Insulin production is sustained during DNA damage-mediated senescence in adult human beta cells" • PMID: 41231256
link.springer.com/article/10.1...
From Drs Peter Thompson, Bruce Verchere and Yi-Chun Chen
"Insulin production is sustained during DNA damage-mediated senescence in adult human beta cells" • PMID: 41231256
link.springer.com/article/10.1...
🧵(4/4) end of Oct 2025.
3) From Dr. Marc Prentki
"ABHD6 suppression attenuates pro-inflammatory responses in mice and promotes anti-inflammatory polarization of macrophages during endotoxin stress" PMID: 41061850
www.sciencedirect.com/science/arti...
3) From Dr. Marc Prentki
"ABHD6 suppression attenuates pro-inflammatory responses in mice and promotes anti-inflammatory polarization of macrophages during endotoxin stress" PMID: 41061850
www.sciencedirect.com/science/arti...
ABHD6 suppression attenuates pro-inflammatory responses in mice and promotes anti-inflammatory polarization of macrophages during endotoxin stress
α/β-hydrolase domain-containing-6 (ABHD6) hydrolyzes various lipids, including monoacylglycerols (MAGs). Pharmacological inhibition of ABHD6 with WWL7…
www.sciencedirect.com
November 3, 2025 at 7:42 PM
🧵(4/4) end of Oct 2025.
3) From Dr. Marc Prentki
"ABHD6 suppression attenuates pro-inflammatory responses in mice and promotes anti-inflammatory polarization of macrophages during endotoxin stress" PMID: 41061850
www.sciencedirect.com/science/arti...
3) From Dr. Marc Prentki
"ABHD6 suppression attenuates pro-inflammatory responses in mice and promotes anti-inflammatory polarization of macrophages during endotoxin stress" PMID: 41061850
www.sciencedirect.com/science/arti...
🧵(3/4) end of Oct 2025.
2) From Dr. Megan Levings
"Lactic acid improves Treg manufacturing and in vivo function" PMID: 41146876
www.cell.com/molecular-th...
2) From Dr. Megan Levings
"Lactic acid improves Treg manufacturing and in vivo function" PMID: 41146876
www.cell.com/molecular-th...
Lactic acid improves Treg manufacturing and in vivo function
Addition of lactic acid to a human Treg manufacturing protocol enhanced viability,
expansion, purity, and suppressive function. Lactic acid also reduced tonic CAR signaling,
preventing expression of e...
www.cell.com
November 3, 2025 at 7:42 PM
🧵(3/4) end of Oct 2025.
2) From Dr. Megan Levings
"Lactic acid improves Treg manufacturing and in vivo function" PMID: 41146876
www.cell.com/molecular-th...
2) From Dr. Megan Levings
"Lactic acid improves Treg manufacturing and in vivo function" PMID: 41146876
www.cell.com/molecular-th...
🧵(2/4) end of Oct 2025.
1) From Dr. Rennian Wang.
"The antioxidant, N-acetyl-L-cysteine, affects beta cell oxidative stress, insulin secretion, and intracellular signaling pathways in MIN6 cells" PMID: 41165773
link.springer.com/article/10.1...
1) From Dr. Rennian Wang.
"The antioxidant, N-acetyl-L-cysteine, affects beta cell oxidative stress, insulin secretion, and intracellular signaling pathways in MIN6 cells" PMID: 41165773
link.springer.com/article/10.1...
The antioxidant, N-acetyl-L-cysteine, affects beta cell oxidative stress, insulin secretion, and intracellular signaling pathways in MIN6 cells - Cell and Tissue Research
There is intense public interest in the potential of antioxidant supplements as a preventative treatment for conditions associated with increased oxidative stress, such as type 2 diabetes mellitus. Ho...
link.springer.com
November 3, 2025 at 7:42 PM
🧵(2/4) end of Oct 2025.
1) From Dr. Rennian Wang.
"The antioxidant, N-acetyl-L-cysteine, affects beta cell oxidative stress, insulin secretion, and intracellular signaling pathways in MIN6 cells" PMID: 41165773
link.springer.com/article/10.1...
1) From Dr. Rennian Wang.
"The antioxidant, N-acetyl-L-cysteine, affects beta cell oxidative stress, insulin secretion, and intracellular signaling pathways in MIN6 cells" PMID: 41165773
link.springer.com/article/10.1...
🧵(4/4) For the first half of October 2025
Lab of Dr. Guy Rutter
"I-BET151 modulates glucokinase gene expression and beta cell function in part through changes in FOXO1 expression"
PMID: 41003698
link.springer.com/article/10.1...
Lab of Dr. Guy Rutter
"I-BET151 modulates glucokinase gene expression and beta cell function in part through changes in FOXO1 expression"
PMID: 41003698
link.springer.com/article/10.1...
I-BET151 modulates glucokinase gene expression and beta cell function in part through changes in FOXO1 expression - Diabetologia
Aims/hypothesis The bromodomain and extra-terminal (BET) protein family acts as ‘epigenetic readers’ to identify the acetylation marks on histones that convert the acetylated lysine residues into obse...
link.springer.com
October 16, 2025 at 1:57 AM
🧵(4/4) For the first half of October 2025
Lab of Dr. Guy Rutter
"I-BET151 modulates glucokinase gene expression and beta cell function in part through changes in FOXO1 expression"
PMID: 41003698
link.springer.com/article/10.1...
Lab of Dr. Guy Rutter
"I-BET151 modulates glucokinase gene expression and beta cell function in part through changes in FOXO1 expression"
PMID: 41003698
link.springer.com/article/10.1...
🧵(3/4) For the first half of October 2025
Labs of Drs. Francis Lynn, James Shapiro and Tatsuya Kin
"Truncated CD19 as a selection marker for the isolation of stem cell derived β-cells"
PMID: 41048051
journals.biologists.com/dmm/article/...
Labs of Drs. Francis Lynn, James Shapiro and Tatsuya Kin
"Truncated CD19 as a selection marker for the isolation of stem cell derived β-cells"
PMID: 41048051
journals.biologists.com/dmm/article/...
October 16, 2025 at 1:57 AM
🧵(3/4) For the first half of October 2025
Labs of Drs. Francis Lynn, James Shapiro and Tatsuya Kin
"Truncated CD19 as a selection marker for the isolation of stem cell derived β-cells"
PMID: 41048051
journals.biologists.com/dmm/article/...
Labs of Drs. Francis Lynn, James Shapiro and Tatsuya Kin
"Truncated CD19 as a selection marker for the isolation of stem cell derived β-cells"
PMID: 41048051
journals.biologists.com/dmm/article/...
🧵(2/4) For the first half of October 2025
Lab of Dr. Bruce Verchere with Dr. Yi-Chun Chen
"Assessment of protein synthesis rate enables metabolic profiling of resident-immune cells of the islets of Langerhans"
PMID: 41063994
www.frontiersin.org/journals/imm...
Lab of Dr. Bruce Verchere with Dr. Yi-Chun Chen
"Assessment of protein synthesis rate enables metabolic profiling of resident-immune cells of the islets of Langerhans"
PMID: 41063994
www.frontiersin.org/journals/imm...
Frontiers | Assessment of protein synthesis rate enables metabolic profiling of resident-immune cells of the islets of Langerhans
Pancreatic islet-resident immune cells, such as lymphocytes and macrophages, support islet homeostasis, beta cell development, and tissue repair. In patholog...
www.frontiersin.org
October 16, 2025 at 1:57 AM
🧵(2/4) For the first half of October 2025
Lab of Dr. Bruce Verchere with Dr. Yi-Chun Chen
"Assessment of protein synthesis rate enables metabolic profiling of resident-immune cells of the islets of Langerhans"
PMID: 41063994
www.frontiersin.org/journals/imm...
Lab of Dr. Bruce Verchere with Dr. Yi-Chun Chen
"Assessment of protein synthesis rate enables metabolic profiling of resident-immune cells of the islets of Langerhans"
PMID: 41063994
www.frontiersin.org/journals/imm...
🧵(7/7) Here are the publications from the 2nd half of Sept.2025
From Dr. Bruce Verchere
“α cells use both PC1/3 and PC2 to process proglucagon peptides and control insulin secretion” PMID: 40971442
www.science.org/doi/10.1126/...
From Dr. Bruce Verchere
“α cells use both PC1/3 and PC2 to process proglucagon peptides and control insulin secretion” PMID: 40971442
www.science.org/doi/10.1126/...
α cells use both PC1/3 and PC2 to process proglucagon peptides and control insulin secretion
α cells can generate and secrete both glucagon and GLP-1 with distinct processing enzymes to control metabolism.
www.science.org
October 1, 2025 at 8:50 PM
🧵(7/7) Here are the publications from the 2nd half of Sept.2025
From Dr. Bruce Verchere
“α cells use both PC1/3 and PC2 to process proglucagon peptides and control insulin secretion” PMID: 40971442
www.science.org/doi/10.1126/...
From Dr. Bruce Verchere
“α cells use both PC1/3 and PC2 to process proglucagon peptides and control insulin secretion” PMID: 40971442
www.science.org/doi/10.1126/...
🧵(6/7) Here are the publications from the 2nd half of Sept.2025
From Dr. James Shapiro
“The bidirectional link between diabetes and pancreatic cancer: A diagnostic aid, risk factor, and potential target for future therapy” PMID: 41005205
www.sciencedirect.com/science/arti...
From Dr. James Shapiro
“The bidirectional link between diabetes and pancreatic cancer: A diagnostic aid, risk factor, and potential target for future therapy” PMID: 41005205
www.sciencedirect.com/science/arti...
The bidirectional link between diabetes and pancreatic cancer: A diagnostic aid, risk factor, and potential target for future therapy
Historically, patients with pancreatic cancer presented with hyperglycemia and glycemic intolerance, leading to a hypothesis that diabetes may be asso…
www.sciencedirect.com
October 1, 2025 at 8:50 PM
🧵(6/7) Here are the publications from the 2nd half of Sept.2025
From Dr. James Shapiro
“The bidirectional link between diabetes and pancreatic cancer: A diagnostic aid, risk factor, and potential target for future therapy” PMID: 41005205
www.sciencedirect.com/science/arti...
From Dr. James Shapiro
“The bidirectional link between diabetes and pancreatic cancer: A diagnostic aid, risk factor, and potential target for future therapy” PMID: 41005205
www.sciencedirect.com/science/arti...
🧵(5/7) Here are the publications from the 2nd half of Sept.2025
From Dr. Patrick MacDonald
"Altered immune and metabolic molecular pathways drive islet cell dysfunction in human type 1 diabetes” PMID: 41026524
www.jci.org/articles/vie...
From Dr. Patrick MacDonald
"Altered immune and metabolic molecular pathways drive islet cell dysfunction in human type 1 diabetes” PMID: 41026524
www.jci.org/articles/vie...
JCI -
Altered immune and metabolic molecular pathways drive islet cell dysfunction in human type 1 diabetes
www.jci.org
October 1, 2025 at 8:50 PM
🧵(5/7) Here are the publications from the 2nd half of Sept.2025
From Dr. Patrick MacDonald
"Altered immune and metabolic molecular pathways drive islet cell dysfunction in human type 1 diabetes” PMID: 41026524
www.jci.org/articles/vie...
From Dr. Patrick MacDonald
"Altered immune and metabolic molecular pathways drive islet cell dysfunction in human type 1 diabetes” PMID: 41026524
www.jci.org/articles/vie...