Chris Chen
@chrispchen.bsky.social
PhD Candidate at UCSF DSCB - Wagner Lab @danwagnerlab
Reposted by Chris Chen
Here is a copy of last year's Twitter thread explaining our preprint - jump to (21) for the new stuff 👀
Synergy between cis-regulatory elements can render cohesin dispensable for distal enhancer function
now revised and journal accepted at www.science.org/doi/10.1126/...
🧵👇
Synergy between cis-regulatory elements can render cohesin dispensable for distal enhancer function
now revised and journal accepted at www.science.org/doi/10.1126/...
🧵👇
November 27, 2025 at 9:59 PM
Here is a copy of last year's Twitter thread explaining our preprint - jump to (21) for the new stuff 👀
Synergy between cis-regulatory elements can render cohesin dispensable for distal enhancer function
now revised and journal accepted at www.science.org/doi/10.1126/...
🧵👇
Synergy between cis-regulatory elements can render cohesin dispensable for distal enhancer function
now revised and journal accepted at www.science.org/doi/10.1126/...
🧵👇
Reposted by Chris Chen
Seahorses have a unique sex role reversal with male pregnancy involving the brood pouch, an evolutionarily novel organ. A study in Nature Ecology & Evolution uses single-cell genomics and in-vivo experiments to reveal the mechanisms of pouch development in seahorses. 🧪
Cellular and molecular mechanisms of seahorse male pregnancy - Nature Ecology & Evolution
Seahorses have a unique sex role reversal with male pregnancy involving the brood pouch, an evolutionarily novel organ. This study uses single-cell genomics and in vivo experiments to reveal the cellular basis and molecular mechanism of pouch development and diversity in seahorses.
go.nature.com
November 29, 2025 at 5:43 PM
Seahorses have a unique sex role reversal with male pregnancy involving the brood pouch, an evolutionarily novel organ. A study in Nature Ecology & Evolution uses single-cell genomics and in-vivo experiments to reveal the mechanisms of pouch development in seahorses. 🧪
Reposted by Chris Chen
🚨 Late preprint alert!
Why do biological process rates scale nonlinearly with temperature, deviating from the straight line on an Arrhenius plot? The key may lie in their inherent complexity!
More in thread and here: doi.org/10.1101/2025...
Why do biological process rates scale nonlinearly with temperature, deviating from the straight line on an Arrhenius plot? The key may lie in their inherent complexity!
More in thread and here: doi.org/10.1101/2025...
October 22, 2025 at 10:29 AM
🚨 Late preprint alert!
Why do biological process rates scale nonlinearly with temperature, deviating from the straight line on an Arrhenius plot? The key may lie in their inherent complexity!
More in thread and here: doi.org/10.1101/2025...
Why do biological process rates scale nonlinearly with temperature, deviating from the straight line on an Arrhenius plot? The key may lie in their inherent complexity!
More in thread and here: doi.org/10.1101/2025...
Reposted by Chris Chen
Relieved to finally post my whole developing brain evolutionary "theory of everything" preprint!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
ANTIPODE Provides a Global View of Cell Type Homology and Transcriptomic Divergence in the Developing Mammalian Brain
Diverse neurons and glia are generated in conserved spatial and temporal sequences during mammalian brain development. Divergence in gene regulatory networks can alter brain composition, scaling, timi...
www.biorxiv.org
October 20, 2025 at 2:50 AM
Relieved to finally post my whole developing brain evolutionary "theory of everything" preprint!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Chris Chen
How can we identify novel regulators of germ layer differentiation and body patterning? I am happy to announce that my preprint using single-cell CRISPR screens in gastruloids to answer this question is now online! Thank you to the rest of the @sendoellab.bsky.social and all coauthors!
Regulation of mRNA polyadenylation governs mammalian body plan formation in gastruloids https://www.biorxiv.org/content/10.1101/2025.07.22.666114v1
July 25, 2025 at 2:59 PM
How can we identify novel regulators of germ layer differentiation and body patterning? I am happy to announce that my preprint using single-cell CRISPR screens in gastruloids to answer this question is now online! Thank you to the rest of the @sendoellab.bsky.social and all coauthors!
Reposted by Chris Chen
Excited to share our new paper by Jessi Cook in collaboration with Michelle Griffin from Mike Longaker's group at Stanford.
www.science.org/stoken/autho...
As nicely described by our communications team:
www.science.org/stoken/autho...
As nicely described by our communications team:
Growth arrest specific–6 and angiotoxin receptor–like signaling drive oral regenerative wound repair
Activation of angiotoxin receptor–like signaling and suppression of focal adhesion kinase allow for regenerative healing in the oral mucosa.
urldefense.com
July 4, 2025 at 7:27 AM
Excited to share our new paper by Jessi Cook in collaboration with Michelle Griffin from Mike Longaker's group at Stanford.
www.science.org/stoken/autho...
As nicely described by our communications team:
www.science.org/stoken/autho...
As nicely described by our communications team:
Reposted by Chris Chen
We need enthusiastic members to join our new lab! Please share!
March 6, 2025 at 7:52 PM
We need enthusiastic members to join our new lab! Please share!