10/10 Lastly, you can confidently travel through the brain, by downloading Neureka and playing Meta Mind today! www.neureka.ie

9/10 A massive thanks to my fantastic co-authors and collaborators, including @kellydonegan.bsky.social 🌟, especially the #Neureka team who gathered all of this wonderful data, our funders and my supervisor @clairegillan.bsky.social 🙏

8/10 Meta Mind exemplifies how to adapt established cognitive tasks for within-person, longitudinal assessments, facilitating the development and testing of causal models 🔄.

7/10 The high reliability observed may suggest that hybrid ‘self-report-cognition’ 🤝 tasks may be overall more reliable than behaviour-only assessments and thus be one way to bridge the reliability gap in computational psychiatry 🌉.

6/10 Metacognitive biases in decision-making are highly stable within-session, exhibit strong reliability 💪 and associations with clinical correlates are evident in as few as 40 trials, facilitating the rapid 🏃‍♀️ detection of individual differences in metacognition

5/10 We additionally observed high test-retest reliability with Meta Mind and replicated previously established associations with psychiatric dimensions 📈 in our very large sample of citizen scientists 🧑‍🔬

4/10 Relative to the traditional task, we demonstrated the convergent validity and excellent split-half reliability of metacognitive bias in Meta Mind ✅. In contrast, metacognitive efficient was neither valid nor reliable ❎ with Meta Mind (likely due to low trial N < 100).

3/10 To achieve this, we developed Meta Mind 🧠, a gamified smartphone task 🤳 designed to measure metacognitive (confidence) bias and investigated its psychometric properties against a traditional metacognitive task

2/10 While metacognitive disturbances have been reported across various aspects of mental health 🙇‍♀️, most research has been cross-sectional. The next frontier is a shift towards repeated assessments of metacognition in individuals over time ⏰, through treatment 💊, and in real world environments 🌍

9/9 Lastly, a massive thanks to my other fantastic co-authors and collaborators, especially the PIP study team who gathered all of this wonderful data 🌟 and my supervisor @clairegillan.bsky.social, and our funders 🙏

8/9 This is important because it suggests that negative biases in anxious-depression are not fixed or final, they can change through time or through treatment.

7/9 Though these samples are too small for individual difference estimates, we note a general pattern across all arms, where changes in confidence over time track changes in anxious-depression. We think this suggests metacognitive biases in anxious-depression are state-dependent.

6/9 Among patients starting antidepressant medication 💊 (N=82) and a control group receiving no intervention 🙅‍♂️ (N=88), we found a significant increase in confidence in the antidepressant arm, but not among controls. Caveat, the interaction is p=0.06 🙃.

5/9 Turning to changes over time – anxious-depression significantly reduced after 4 weeks of iCBT 📉, and this was accompanied by an increase in confidence 📈. Importantly, those with the greatest reductions in anxious-depression levels had the largest increase in confidence.

4/9 Prior to receiving iCBT, ‘anxious-depression’ was associated with under-confidence, while ‘compulsive and intrusive thoughts’ was associated with over-confidence in performance, replicating 🔄 previous work and extending it to a new sample - treatment seeking patients.

3/9 They signed up online and completed a metacognitive task and self-report questionnaires at baseline and 4-week follow-up, without ever meeting us 🧑‍💻

2/9 We collected these data as part of the PIP study, introduced by @ctlee.bsky.social. Participants initiating iCBT from SilverCloud via an NHS site or an Irish mental charity Aware, were invited to take part in our study. More on that here ⬇️

bmcpsychiatry.biomedcentral.com/articles/10....

Thanks Micah! Glad you enjoyed, looking forward to chatting with you when you visit us in the new year!